CD21 Products

Description

CD21 (complement receptor 2, CR2) binds C3 complement fragments, especially its breakdown fragments, which remain covalently attached to complement activating surfaces or antigen. CD21 has important roles in uptake and retention of immunocomplexes, survival of memory B cells and in development and maintenance of the humoral response to T-dependent antigens. CD21 also serves as a key receptor for Epstein-Barr virus binding and is involved in targeting prions to folicular dendritic cells and expediting neuroinvasion following peripheral exposure to prions. A soluble form of the CD21 (sCD21) is shed from the lymphocyte surface and retains its ability to bind respective ligands.

Bioinformatics

Entrez	12902 Mouse 1380 Human
Uniprot	O15181 Human P20023 Human
Product By Gene ID	1380
Alternate Names	C3DRSLEB9 CD21 antigen CD21 Complement C3d receptor complement component (3d/Epstein Barr virus) receptor 2 complement receptor type 2 Cr2 EBV receptor Epstein-Barr virus receptor

Research Areas for CD21

Find related products by research area and learn more about each of the different research areas below.

Adaptive Immunity
CD Markers
Dendritic Cell Markers
Immunology

Related CD21 Blog Posts

Check out the latest blog posts on CD21.

How To Identify B Cell Subsets Using Flow Cytometry By Victoria OsinskiUsing Flow Cytometry to Identify B Cell SubsetsIdentifying cellular subsets by flow cytometry requires careful and thorough planning in order to ensure the correct subset of cells are identified...    Read more.

CD19: An Undoubted Biomarker for B Cells CD19 is a cell surface protein member of the large immunoglobulin superfamily that complexes with CD21, CD81, and CD225 in the membrane of mature B-cells. A major function of CD19 is to assemble with the antigen receptor of B-lymphocytes to decrease t...    Read more.

Read more CD21 related blogs.