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Staufen1 Overabundance and the Consequent mTOR Hyperactivity in Amyotrophic Lateral Sclerosis, Spinocerebellar Ataxia Type 2, Alzheimer’s, Parkinson’s, and Huntington’s Diseases

3D rendering of neurons as a banner image.

Jamshed Arslan, Pharm D, PhD

Tags: 
Amyotrophic Lateral Sclerosis
ALS
Spinocerebellar Ataxia Type 2
Alzheimer’s
Parkinson’s
Huntington’s
neurodegeneration
Autophagy
Neurons
Staufen
TOR/mTOR
Jamshed Arslan

Transcriptional co-activators Yap1 and Taz control growth and development

Schematic of Hippo signaling pathway highlighting Yap and Taz proteins.

By Jamshed Arslan, Pharm D, PhD

Tags: 
Apoptosis
Cancer
Cell Proliferation
Embryonic Stem Cells
Hypoxia
Pluripotency
Stem Cells
Hippo
YAP1
TAZ
TAZ/WWTR1
TEF1
TEAD4
MCM3
MCM4
MCM6
MCM10
OCT1
Sox2
cIAP-1/HIAP-2
Survivin
Bcl-2
Mcl-1
cdx2
gata-3
HNF-4 alpha/NR2A1
Jagged 1
MYF-5
MYF6
Myogenin
Prox1
N-cadherin
Vimentin
SNAIL
Slug
TAK1
MDH2
HIF-1 alpha
Jamshed Arslan

Pattern recognition receptors (PRR) expression and function in endothelial cells

Banner image cartoon depicting a portion of the TLR signaling pathway.

By Victoria Osinski

Tags: 
Cancer
Cytokines
immunology
Innate Immunity
Toll-Like Receptors
Endothelial Cell
endothelial marker
LPS
Heat Shock Proteins
Vasculature
NFkB
NFkB1/NFkB p105
TLRs
TLR2
TLR3
TLR6
TLR7
TLR8
MMR/CD206/Mannose Receptor
CLEC4E
Dectin-1/CLEC7A
DLEC/CLEC4C/BDCA-2
DCAR/CLEC4B
CLEC-1
CLEC9A
SIGNR2/CD209d
MDEL-1/CLEC5A
CIITA
NOD1
NOD2
NLRC3
NLRC5
NLRX1
NLRP
NAIP
RIG-I
MDA5
DHX58
AGER
HMGB1/HMG-1
CXCL8/IL-8
TNF-alpha
MyD88
E-Selectin/CD62E
CD31/PECAM-1
CCL2/JE/MCP-1
IL-6
beta-catenin
VE-Cadherin
Victoria Osinski

Bad news for stomach cancer: BAMBI protein inhibits gastric carcinoma via TGF-beta/epithelial-mesenchymal transition signaling

Collagen-I expression in rat colon tissue IHC

By Jamshed Arslan Pharm.D.

Tags: 
Epigenetics
Cancer
Tumor
Hypoxia
TGF-beta
HIF-1 alpha
Bambi
SOX4
VIM
MMP9
Ki67
IPO-38
N-cadherin
Collagen-1
Snai1
Acta2
Twist1
Fibronectin
EMT

Combined NOTCH/MAPK inhibition: A promising new anticancer approach

MAPK signaling pathway Novus Biologicals

By Yoskaly Lazo-Fernandez, PhD

Tags: 
NOTCH
MAPK
Colon Cancer
MEK
EMT
NICD
FRA1
Cancer
Metastasis
Tumor

Nuclear LC3: Why is it there and what is it doing?

hHpr1-p84-Thoc1 Antibody

By Christina Towers, PhD.

Tags: 
Autophagy
LC3
p62/SQSTM1
Lysosome
autophagosome
ATG
ATG7
ATG8 and ATG4B
LC3A

CAR-T Cell Therapy: Refining the Approach in Solid Tumors

CAR-T Cell Killing

By Jacqueline Carrico, BS, MD Candidate

Tags: 
Cancer
Tumor
Lymphocytes
CD4
CD8
immunology
PKA
Cytokines

Killing two birds with one stone: Treating inflammation and cancer by inhibiting prolyl-4-hydroxylase-1

Bi-directional Cross-talk Between HIF1-alpha and NF kappa B

By Jamshed Arslan Pharm.D.

Tags: 
Hypoxia
HIF
PHD
Inflammation
Cancer
p53
NF-kB
Apoptosis
RelA/NFkB p65

Getting Physical: Link between Lipid Metabolism and Hypoxia Target Genes

Autophagy Mechanisms

By Jamshed Arslan Pharm.D.

Tags: 
HIF
HIF-1alpha
p-VHL
FASN
Hypoxia
Cancer
VEGF

Autophagy inhibition in pediatrics: One physician-scientist’s brave decision

Autophagy Pathway, Novus Biologicals, macroautophagy induction, autophagosome maturation, microautophagy, autolysosome, elongation

By Christina Towers, PhD.

Tags: 
Autophagy
Cancer
ATG
Tumor
Immune System
immunity
T-Cells
LC3B
p62/SQSTM1
Lysosome
Neuroscience
Brain
neurodegeneration
Chloroquine
vemurafenib
oncology
Christina Towers

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