Species: Hu, Mu
Applications: WB, Flow, ICC/IF, IP, ChIP
Host: Mouse Monoclonal
Species: Hu, Mu, Rt, Ca, Fe, Po, Bv, Ca, Ch, Pm, Fe, Xp
Applications: WB, ICC/IF, IHC, IP
Host: Rabbit Polyclonal
Species: Hu, Mu, Rt, Bv, Ch, Fe, Pm, Rb, Ze
Applications: WB, ICC/IF, IHC
Host: Rabbit Polyclonal
Species: Hu
Applications: WB
Species: Hu
Applications: AC
Species: Hu
Applications: WB, ELISA, MA, AP
Species: Hu
Applications: AC
Description
Bmi1 polycomb ring finger oncogene regulates the cell cycle inhibitor genes p16 and p19, with implications in hematopoiesis, skeletal patterning, neurological functions, and development of the cerebellum. Bmi 1 has been shown to induce telomerase activity and immortalize human mammary epithelial cells, and extend the replicative life span of human fibroblasts by suppressing the p16-dependent senescence pathway. Bmi-1 is also required for efficient self-renewing cell division in adult hematopoietic and neural stem cells.
Aberrant expression of Bmi-1 has been found in several types of cancer in the bladder, skin, blood, prostate, breast, ovaries, andcolon. Its overexpression is especially pronounced in mantle cell lymphomas. Thereforem Bmi1 antibodies will be useful tools for many cancer development studies.
Bioinformatics
| Entrez |
Mouse
Rat
Human
|
| Uniprot |
Human
Human
Human
Human
Human
Mouse
Human
Human
|
| Product By Gene ID |
648 |
| Alternate Names |
- B lymphoma Mo-MLV insertion region 1 homolog (mouse)
- B lymphoma Mo-MLV insertion region 1 homolog
- BMI1 polycomb ring finger oncogene
- FLVI2/BMI1
- MGC12685
- murine leukemia viral (bmi-1) oncogene homolog
- PCGF4
- polycomb complex protein BMI-1
- polycomb group protein Bmi1
- polycomb group ring finger 4
- RING finger protein 51
- RNF51Polycomb group RING finger protein 4
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