TrkB Products

Description

TrkB is a tyrosine-protein kinase receptor involved in the development and/or maintenance of the nervous system. TrkB is a receptor for brain-derived neurotrophic factor (BDNF), neurotrophin-3 and neurotrophin-4/5, but not nerve growth factor (NGF). The major substrates for the TRK receptors are SHC1, PI-3 kinase, and PLC-gamma-1.

Bioinformatics

Entrez	18212 Mouse 25054 Rat 4915 Human
Uniprot	AAH31835 Human AAH31835.1 Human NM_001007097 Human NM_001018064 Human NM_001018064. Human NM_006180 Human NM_006180.3 Human NP_001007098.1 Human P15209 Mouse Q16620 Human Q63604 Rat
Product By Gene ID	4915
Alternate Names	BDNF/NT-3 growth factors receptor EC 2.7.10 EC 2.7.10.1 GP145-TrkB Neurotrophic tyrosine kinase receptor type 2 neurotrophic tyrosine kinase, receptor, type 2 TrkB tyrosine kinase trk-B Trk-B TRKBBDNF-tropomyosine receptor kinase B tyrosine kinase receptor B

Research Areas for TrkB

Find related products by research area and learn more about each of the different research areas below.

GPCR
Phospho-Specific
Protein Kinase
Signal Transduction

Related TrkB Blog Posts

Check out the latest blog posts on TrkB.

TrkB: Docking for Neurotrophins and Beyond. Tropomyosin receptor kinase B (TrkB) is a member of the Trk receptor tyrosine kinases family consisting of TrkA, TrkB and TrkC. The sequence of these family members is highly conserved. TrK's are activated by several neurotrophins, which are small pro...    Read more.

TrkB and Nervous System Function Neutrophins and their receptors play an important role in regulating the development of both the central and peripheral nervous systems. Neurotrophin ligand binding to each of their respective Trk cellular receptors is essential for the growth and sur...    Read more.

TrkB: Bridging Ontogenesis and Oncogenesis Tropomyosin receptor kinase B (TrkB) is a member of the Trk receptor tyrosine kinases family consisting of TrkA, TrkB and TrkC. The sequence of these family members is highly conserved. Interaction of brain-derived neurotrophic factor (BDNF) with its ...    Read more.

Successful Transplantation of Friedreich Ataxia Induced Pluripotent Stem Cell (iPSC)-Derived Sensory Neurons in Dorsal Root Ganglia of Adult Rodents Jamshed Arslan, Pharm D, PhD The dorsal root ganglia (DRG) are a collection of cell bodies of sensory nerves carrying sensory information – including nociception, mechanoreception and proprioception – from periphera...    Read more.

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