Recombinant Human XLF His Protein

Non-homologous end-joining factor 1, also known as NHEJ1, belongs to the XLF family. NHEJ1 was originally discovered as the protein mutated in five patients with growth retardation, microcephaly, and immunodeficiency. The protein is required for the non-homologous end joining (NHEJ) pathway of DNA repair. Patients with NHEJ1 mutations also have immunodeficiency due to a defect in V(D)J recombination, which utilizes NHEJ to promote immune system diversity. XLF interacts with DNA ligase IV and XRCC4 and is thought to be involved in the ligation step of NHEJ. Recombinant human NHEJ1 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 3 months from date of receipt.

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Publication using NBP2-23291	Applications	Species
Cabello-Lobato MJ, Jenner M, Cisneros-Aguirre M et al. Microarray screening reveals two non-conventional SUMO-binding modules linked to DNA repair by non-homologous end-joining Nucleic acids research 2022-05-06 [PMID: 35420136]

Array NBP2-23291

• XLF Antibodies
• XLF Lysate
• XLF Proteins