VAMP-8 Antibody [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

VAMP-8 (vesicle associated membrane protein 8; also endobrevin) is a 12 kDa member of the synaptobrevin family of proteins. It is a type IV transmembrane (TM) protein (i.e.- a type II TM protein whose C-terminus is predominately transmembrane) that is found in cells involved in vesicle release (platelets, mast cells and pancreatic acinar cells). It regulates exocytosis and decouples granule release from cytokine release. Human VAMP-8 is 100 amino acids (aa) in length. It contains a vSNARE coiled-coil homology region (aa 12-72) and a membrane-anchor domain (aa 76‑96). Over aa 1‑75, human VAMP-8 shares 93% aa identity with mouse
VAMP‑2.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Rat.

We have publications tested in 2 applications: IHC, Western Blot.

Showing Publications 1 - 6 of 6.

Publications using AF5354	Applications	Species
S Ganesan, NN Alvarez, S Steiner, KM Fowler, AK Corona, CR Roy Syntaxin 11 Contributes to the Interferon-Inducible Restriction of Coxiella burnetii Intracellular Infection MBio, 2023-02-02;0(0):e0354522. 2/2/2023 [PMID: 36728431]
Ildar Gabaev, James C. Williamson, Thomas W.M. Crozier, Thomas F. Schulz, Paul J. Lehner Quantitative Proteomics Analysis of Lytic KSHV Infection in Human Endothelial Cells Reveals Targets of Viral Immune Modulation Cell Reports 10/13/2020 [PMID: 33053346]
SM Madhavan, JF O'Toole, M Konieczkow, L Barisoni, DB Thomas, S Ganesan, LA Bruggeman, M Buck, JR Sedor APOL1 variants change C-terminal conformational dynamics and binding to SNARE protein VAMP8 JCI Insight, 2017-07-20;2(14):. 2017-07-20 [PMID: 28724794] (IHC, Human)	IHC	Human
Sang Su Woo, Declan J James, Thomas F J Martin Munc13-4 functions as a Ca2+ sensor for homotypic secretory granule fusion to generate endosomal exocytic vacuoles. Molecular Biology of the Cell, 2017-01-18;0(0):1939-4586. 2017-01-18 [PMID: 28100639] (Western Blot, Rat)	Western Blot	Rat
Zhu Q, Yamakuchi M, Lowenstein C SNAP23 Regulates Endothelial Exocytosis of von Willebrand Factor. PLoS ONE, 2015-08-12;10(8):e0118737. 2015-08-12 [PMID: 26266817] (IHC, Western Blot, Human)	IHC, Western Blot	Human
Henri-François Renard, Maria Daniela Garcia-Castillo, Valérie Chambon, Christophe Lamaze, Ludger Johannes Shiga toxin stimulates clathrin-independent endocytosis of the VAMP2, VAMP3 and VAMP8 SNARE proteins Journal of Cell Science 8/1/2015 [PMID: 26071526]

Images	Ratings	Applications	Species	Date	Details
Enlarge	5 reviewed by: Scott Messenger	WB	Human	04/25/2017	View Summary Application Western Blot Sample Tested T84 human colon carcinoma cell line Species Human Comments Comments 100 ug whole cell lystate 15% gel

Array AF5354

• VAMP-8 Antibodies
• VAMP-8 Lysate
• VAMP-8 Proteins