TREM2 Antibody (237920) [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

TREM2 (Triggering Receptor Expressed on Myeloid cells-2) is a 35 kDa molecular weight type I transmembrane member of the TREM family and Ig superfamily . Mature human TREM2 consists of a 156 amino acid (aa) extracellular domain (ECD) with one V-type Ig-like domain, a 21 aa transmembrane (TM) domain, and a 35 aa cytoplasmic tail. Within the ECD, human TREM2 shares 73% and 74% aa sequence identity with mouse and rat TREM2, respectively. Two closely related transcripts were reported in mouse and designated TREM2a and TREM2b. Soluble forms of the TREM2 ECD are generated by alternative splicing or proteolytic cleavage, and the cytoplasmic domain can be liberated by gamma-Secretase mediated intramembrane cleavage. It is a pattern recognition receptor that binds anionic ligands. A positively charged lysine within the transmembrane segment allows association with the signal adapter protein, DAP12 to deliver an activating signal that plays a role in both innate and adaptive immune responses, including inhibition of macrophage activation. TREM2 is expressed on macrophages, immature myeloid dendritic cells, osteoclasts, microglia, and adipocytes. It promotes the differentiation and function of osteoclasts, the production of inflammatory cytokines by adipocytes, insulin resistance, and the phagocytic clearance of bacteria. In the CNS, TREM2 binds to ApoE, ApoA1, and ApoB and mediates the clearance of apoptotic neurons, amyloid plaques, and cell debris following demyelination. TREM2 also interacts with and modifies signaling through Plexin A1 on dendritic cells and osteoclasts. Mutations in TREM2 or DAP12 are associated with the development of Alzheimer's disease and Nasu-Hakola disease (NHD/PLOSL) which is characterized by presenile dementia and bone cysts. Soluble TREM2 is elevated in cerebrospinal fluid of patients with active multiple sclerosis (MS), and TREM2 blockade exacerbates disease symptoms in the experimental EAE model of MS.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 5 confirmed species: Human, Mouse, Rat, N/A, Transgenic Mouse.

We have publications tested in 12 applications: CyTof, ELISA Capture, ELISA Detection, ELISA Development (Capture), Flow Cytometry, Functional Assay, ICC, IHC, IHC-P, Neutralization, Receptor Recycling, Western Blot.

Showing Publications 1 - 10 of 35. Show All 35 Publications. Collapse Publications.

Publications using MAB17291	Applications	Species
Pierro, EW;Cottam, MA;An, H;Lehmann, BD;Pietenpol, JA;Wellen, KE;Makowski, L;Rathmell, JC;Fingleton, B;Hasty, AH; Trem2 deficiency attenuates breast cancer tumor growth in lean, but not obese or weight loss, mice and is associated with alterations of clonal T cell populations bioRxiv : the preprint server for biology 2024-09-27 [PMID: 39386686] (ELISA Capture, Mouse)	ELISA Capture	Mouse
Arsenault, R;Marshall, S;Salois, P;Li, Q;Zhang, W; sTREM2 Differentially Affects Cytokine Expression in Myeloid-Derived Cell Models via MAPK-JNK Signaling Pathway Biology 2024-01-30 [PMID: 38392305] (Flow Cytometry, Human)	Flow Cytometry	Human
Chen, J;Zhu, T;Jiang, G;Zeng, Q;Li, Z;Huang, X; Target delivery of a PD-1-TREM2 scFv by CAR-T cells enhances anti-tumor efficacy in colorectal cancer Molecular cancer 2023-08-10 [PMID: 37563723] (IHC, Mouse)	IHC	Mouse
Yin, T;D'Adamio, L; BRI2-mediated regulation of TREM2 processing in microglia and its potential implications for Alzheimer's disease and related dementias bioRxiv : the preprint server for biology 2023-06-14 [PMID: 37398330] (ELISA Detection, Mouse, N/A, Transgenic Mouse)	ELISA Detection	Mouse, N/A, Transgenic Mouse
Gao, H;Di, J;Clausen, BH;Wang, N;Zhu, X;Zhao, T;Chang, Y;Pang, M;Yang, Y;He, R;Wang, Y;Zhang, L;Liu, B;Qiu, W;Lambertsen, KL;Brambilla, R;Rong, L; Distinct myeloid population phenotypes dependent on TREM2 expression levels shape the pathology of traumatic versus demyelinating CNS disorders Cell reports 2023-06-07 [PMID: 37289590] (IHC, Mouse)	IHC	Mouse
Thu, VTA;Hoang, TX;Kim, JY; 1,25-Dihydroxy Vitamin D3 Facilitates the M2 Polarization and ?-Amyloid Uptake by Human Microglia in a TREM2-Dependent Manner BioMed research international 2023-05-27 [PMID: 37274074] (Neutralization, Human)	Neutralization	Human
Su, P;Zhang, J;Wu, J;Chen, H;Luo, W;Hu, M; TREM2 expression on the microglia resolved lead exposure-induced neuroinflammation by promoting anti-inflammatory activities Ecotoxicology and environmental safety 2023-05-26 [PMID: 37245276] (IHC, Mouse)	IHC	Mouse
Haensel, D;Daniel, B;Gaddam, S;Pan, C;Fabo, T;Bjelajac, J;Jussila, AR;Gonzalez, F;Li, NY;Chen, Y;Hou, J;Patel, T;Aasi, S;Satpathy, AT;Oro, AE; Skin basal cell carcinomas assemble a pro-tumorigenic spatially organized and self-propagating Trem2+ myeloid niche Nature communications 2023-05-10 [PMID: 37164949] (Neutralization, Human)	Neutralization	Human
Miguel Moutinho, Israel Coronel, Andy P. Tsai, Gonzalo Viana Di Prisco, Taylor Pennington, Brady K. Atwood et al. TREM2 splice isoforms generate soluble TREM2 species that disrupt long-term potentiation Genome Medicine 2/20/2023 [PMID: 36805764]
X Shu, C Wei, WY Tu, K Zhong, S Qi, A Wang, L Bai, SX Zhang, B Luo, ZZ Xu, K Zhang, C Shen Negative regulation of TREM2-mediated C9orf72 poly-GA clearance by the NLRP3 inflammasome Cell Reports, 2023-02-16;42(2):112133. 2023-02-16 [PMID: 36800288] (ELISA Capture, Mouse)	ELISA Capture	Mouse
B van Lenger, L Zhan, D Xia, D Chan, D Joy, JI Park, D Tatarakis, M Calvert, S Hummel, S Lianoglou, ME Pizzo, R Prorok, E Thomsen, LM Bartos, P Beumers, A Capell, SS Davis, L de Weerd, JC Dugas, J Duque, T Earr, K Gadkar, T Giese, A Gill, J Gnörich, C Ha, M Kannuswamy, DJ Kim, ST Kunte, LH Kunze, D Lac, K Lechtenber, AW Leung, CC Liang, I Lopez, P McQuade, A Modi, VO Torres, HN Nguyen, I Pesämaa, N Propson, M Reich, Y Robles-Col, K Schlepckow, L Slemann, H Solanoy, JH Suh, RG Thorne, C Vieira, K Wind-Mark, K Xiong, YJY Zuchero, D Diaz, MS Dennis, F Huang, K Scearce-Le, RJ Watts, C Haass, JW Lewcock, G Di Paolo, M Brendel, PE Sanchez, KM Monroe A TREM2-activating antibody with a blood-brain barrier transport vehicle enhances microglial metabolism in Alzheimer's disease models Nature Neuroscience, 2023-01-12;0(0):. 2023-01-12 [PMID: 36635496] (Flow Cytometry, Human)	Flow Cytometry	Human
Choi C, Kim H, Oh J et al. DSCR1 deficiency ameliorates the A beta pathology of Alzheimer's disease by enhancing microglial activity Life science alliance 2/1/2023 [PMID: 36450444] Details: Dilution used was 1:500
AL Thomas, MA Lehn, EM Janssen, DA Hildeman, CA Chougnet Naturally-aged microglia exhibit phagocytic dysfunction accompanied by gene expression changes reflective of underlying neurologic disease Scientific Reports, 2022-11-14;12(1):19471. 2022-11-14 [PMID: 36376530] (Flow Cytometry, Mouse)	Flow Cytometry	Mouse
BF Vahsen, E Gray, A Candalija, KML Cramb, J Scaber, R Dafinca, A Katsikoudi, Y Xu, L Farrimond, R Wade-Marti, WS James, MR Turner, SA Cowley, K Talbot Human iPSC co-culture model to investigate the interaction between microglia and motor neurons Scientific Reports, 2022-07-23;12(1):12606. 2022-07-23 [PMID: 35871163] (ICC, Human)	ICC	Human
Sanjay, Jae-Ho Shin, Miey Park, Hae-Jeung Lee Cyanidin-3-O-Glucoside Regulates the M1/M2 Polarization of Microglia via PPAR gamma and A beta 42 Phagocytosis Through TREM2 in an Alzheimer’s Disease Model Molecular Neurobiology 8/1/2022 [PMID: 35670898]
K Cosker, A Mallach, J Limaye, TM Piers, J Staddon, SJ Neame, J Hardy, JM Pocock Microglial? signalling pathway deficits associated with the patient derived R47H TREM2 variants linked to AD indicate inability to activate inflammasome Scientific Reports, 2021-06-25;11(1):13316. 2021-06-25 [PMID: 34172778] (Functional Assay, Human)	Functional Assay	Human
C Munn, S Burton, S Dickerson, K Bakshy, A Strouse, D Rajesh Generation of cryopreserved macrophages from normal and genetically engineered human pluripotent stem cells for disease modelling PLoS ONE, 2021-04-22;16(4):e0250107. 2021-04-22 [PMID: 33886609] (ICC, Human)	ICC	Human
HR Chen, CW Chen, N Mandhani, JC Short-Mill, MR Smucker, YY Sun, CY Kuan Monocytic Infiltrates Contribute to Autistic-like Behaviors in a Two-Hit Model of Neurodevelopmental Defects J Neurosci, 2020-10-30;0(0):. 2020-10-30 [PMID: 33127853] (Flow Cytometry, Mouse)	Flow Cytometry	Mouse
Olena Korvatska, Kostantin Kiianitsa, Alexander Ratushny, Mark Matsushita, Neal Beeman, Wei-Ming Chien et al. Triggering Receptor Expressed on Myeloid Cell 2 R47H Exacerbates Immune Response in Alzheimer’s Disease Brain Frontiers in Immunology 9/25/2020 [PMID: 33101276]
Y Wang, Y Shi, Y Huang, W Liu, G Cai, S Huang, Y Zeng, S Ren, H Zhan, W Wu Resveratrol mediates mechanical allodynia through modulating inflammatory response via the TREM2-autophagy axis in SNI rat model J Neuroinflammation, 2020-10-21;17(1):311. 2020-10-21 [PMID: 33081801] (IHC, Western Blot, Rat)	IHC, Western Blot	Rat
BL Heckmann, BJW Teubner, E Boada-Rome, B Tummers, C Guy, P Fitzgerald, U Mayer, S Carding, SS Zakharenko, T Wileman, DR Green Noncanonical function of an autophagy protein prevents spontaneous Alzheimer's disease Sci Adv, 2020-08-14;6(33):eabb9036. 2020-08-14 [PMID: 32851186] (ICC, Receptor Recycling, Western Blot, Mouse)	ICC, Receptor Recycling, Western Blot	Mouse
BJ Andreone, L Przybyla, C Llapashtic, A Rana, SS Davis, B van Lenger, K Lin, J Shi, Y Mei, G Astarita, G Di Paolo, T Sandmann, KM Monroe, JW Lewcock Alzheimer's-associated PLCgamma2 is a signaling node required for both TREM2 function and the inflammatory response in human microglia Nat. Neurosci., 2020-06-08;0(0):. 2020-06-08 [PMID: 32514138] (Flow Cytometry, Human, Mouse)	Flow Cytometry	Human, Mouse
Heckmann B L, Teubner B J W et al. LC3-Associated Endocytosis Facilitates beta-Amyloid Clearance and Mitigates Neurodegeneration in Murine Alzheimer's Disease. Cell 7/25/2019 [PMID: 31257024]
JK Götzl, M Brendel, G Werner, S Parhizkar, L Sebastian, G Kleinberge, AV Colombo, M Deussing, M Wagner, J Winkelmann, J Diehl-Schm, J Levin, K Fellerer, A Reifschnei, S Bultmann, P Bartenstei, A Rominger, S Tahirovic, ST Smith, C Madore, O Butovsky, A Capell, C Haass Opposite microglial activation stages upon loss of PGRN or TREM2 result in reduced cerebral glucose metabolism EMBO Mol Med, 2019-06-01;0(0):. 2019-06-01 [PMID: 31122931] (ELISA Detection, Mouse)	ELISA Detection	Mouse
L Zhong, Y Xu, R Zhuo, T Wang, K Wang, R Huang, D Wang, Y Gao, Y Zhu, X Sheng, K Chen, N Wang, L Zhu, D Can, Y Marten, M Shinohara, CC Liu, D Du, H Sun, L Wen, H Xu, G Bu, XF Chen Soluble TREM2 ameliorates pathological phenotypes by modulating microglial functions in an Alzheimer's disease model Nat Commun, 2019-03-25;10(1):1365. 2019-03-25 [PMID: 30911003] (ELISA Development (Capture), Mouse, Transgenic Mouse)	ELISA Development (Capture)	Mouse, Transgenic Mouse
MA Russo, NT Fiore, C van Vreden, D Bailey, DM Santarelli, HM McGuire, B Fazekas de, PJ Austin Expansion and activation of distinct central memory T lymphocyte subsets in complex regional pain syndrome J Neuroinflammation, 2019-03-18;16(1):63. 2019-03-18 [PMID: 30885223] (CyTof, Human)	CyTof	Human
Kota Kurisu, Zhen Zheng, Jong Youl Kim, Jian Shi, Atsushi Kanoke, Jialing Liu et al. Triggering receptor expressed on myeloid cells-2 expression in the brain is required for maximal phagocytic activity and improved neurological outcomes following experimental stroke Journal of Cerebral Blood Flow & Metabolism 10/1/2019 [PMID: 30523715]
P Garcia-Rei, A Phillips, TM Piers, C Villegas-L, M Butler, A Mallach, C Rodrigues, CE Arber, A Heslegrave, H Zetterberg, H Neumann, S Neame, H Houlden, J Hardy, JM Pocock Human Induced Pluripotent Stem Cell-Derived Microglia-Like Cells Harboring TREM2 Missense Mutations Show Specific Deficits in Phagocytosis Cell Rep, 2018-08-28;24(9):2300-2311. 2018-08-28 [PMID: 30157425] (Human)		Human
SM Kim, BR Mun, SJ Lee, Y Joh, HY Lee, KY Ji, HR Choi, EH Lee, EM Kim, JH Jang, HW Song, I Mook-Jung, WS Choi, HS Kang TREM2 promotes A? phagocytosis by upregulating C/EBP?-dependent CD36 expression in microglia Sci Rep, 2017-09-11;7(1):11118. 9/11/2017 [PMID: 28894284]
Divya Raj, Zhuoran Yin, Marjolein Breur, Janine Doorduin, Inge R. Holtman, Marta Olah et al. Increased White Matter Inflammation in Aging- and Alzheimer’s Disease Brain Frontiers in Molecular Neuroscience 6/30/2017 [PMID: 28713239]
MM Varnum, KA Clayton, A Yoshii-Kit, G Yonemoto, L Koro, S Ikezu, T Ikezu A split-luciferase complementation, real-time reporting assay enables monitoring of the disease-associated transmembrane protein TREM2 in live cells J. Biol. Chem., 2017-05-10;0(0):. 2017-05-10 [PMID: 28490631] (Functional Assay, Human)	Functional Assay	Human
Sandro Alves Interleukin-2 improves amyloid pathology, synaptic failure and memory in Alzheimer's disease mice Brain, 2017-03-01;0(0):. 2017-03-01 [PMID: 28003243] (IHC, Mouse)	IHC	Mouse
Savage J, Jay T, Goduni E, Quigley C, Mariani M, Malm T, Ransohoff R, Lamb B, Landreth G Nuclear receptors license phagocytosis by trem2+ myeloid cells in mouse models of Alzheimer's disease. J Neurosci, 2015-04-22;35(16):6532-43. 2015-04-22 [PMID: 25904803] (Flow Cytometry, Mouse)	Flow Cytometry	Mouse
Wu K, Byers D, Jin X, Agapov E, Alexander-Brett J, Patel A, Cella M, Gilfilan S, Colonna M, Kober D, Brett T, Holtzman M TREM-2 promotes macrophage survival and lung disease after respiratory viral infection. J Exp Med, 2015-04-20;212(5):681-97. 2015-04-20 [PMID: 25897174] (Flow Cytometry, IHC-P, Mouse)	Flow Cytometry, IHC-P	Mouse
Kawabori M, Kacimi R, Kauppinen T, Calosing C, Kim J, Hsieh C, Nakamura M, Yenari M Triggering receptor expressed on myeloid cells 2 (TREM2) deficiency attenuates phagocytic activities of microglia and exacerbates ischemic damage in experimental stroke. J Neurosci, 2015-02-25;35(8):3384-96. 2015-02-25 [PMID: 25716838] (IHC, Mouse)	IHC	Mouse
Show All 35 Publications. Collapse Publications.

Array MAB17291

• TREM2 Antibodies
• TREM2 Antibody Pair
• TREM2 ELISA Kits
• TREM2 Lysate
• TREM2 Protein
• TREM2 ELISA
• TREM2 Proteins and Enzymes