Orthogonal Strategies: Western Blot: Thioredoxin Reductase 1/TRXR1 Antibody [NBP1-81791] - Analysis in human cell lines PC-3 and MCF-7 using Anti-TXNRD1 antibody. Corresponding TXNRD1 RNA-seq data are presented ...read more
Immunohistochemistry-Paraffin: Thioredoxin Reductase 1/TRXR1 Antibody [NBP1-81791] - Staining of human testis shows strong cytoplasmic and nuclear positivity in Leydig cells and basal cells in the seminiferous ducts.
Western Blot: Thioredoxin Reductase 1/TRXR1 Antibody [NBP1-81791] - Lane 1: Marker [kDa] 219, 112, 85, 49, 32, 25, 18. Lane 2: Human cell line RT-4. Lane 3: Human cell line U-251MG sp. Lane 4: Human cell line ...read more
This antibody was developed against Recombinant Protein corresponding to amino acids: SCEDGRALEGTLSELAAETDLPVVFVKQRKIGGHGPTLKAYQEGRLQKLLKMNGPEDLPKSYDYDLIIIGGGSGGLAAAKEAAQYGKKVMVLDFVTPTPLGTRWGLGGTCVNVGCIPKKLMHQAALLGQALQDSRNYG
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
TXNRD1
Purity
Immunogen affinity purified
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Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.2) and 40% Glycerol
Preservative
0.02% Sodium Azide
Purity
Immunogen affinity purified
Alternate Names for Thioredoxin Reductase 1/TRXR1 Antibody
EC 1.8.1
EC 1.8.1.9
Gene associated with retinoic and IFN-induced mortality 12 protein
Gene associated with retinoic and interferon-induced mortality 12 protein
GRIM12
GRIM-12
GRIM-12TR1
KDRF
KM-102-derived reductase-like factor
MGC9145
oxidoreductase
Thioredoxin Reductase 1
thioredoxin reductase 1, cytoplasmic
thioredoxin reductase GRIM-12
Thioredoxin reductase TR1
TR
TR1
TRXR1
TRXRD1
TXNR
TXNRD1
TXNRTRXR1
Background
thioredoxin reductase 1 is a pyridine nucleotide oxidoreductase which reduces thioredoxins as well as other substrates, and plays a role in selenium metabolism and protection against oxidative stress. It is thought to function as a homodimer which uses FAD as a cofactor. Each subunit contains a selenocysteine residue which is required for the catalytic activity. Alternative splicing results in several transcript variants encoding the same protein. Additional transcript variants have been described but their biological validity has not been determined.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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