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SP-D Antibody (1.7) [FITC]

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Product Details

Summary
Reactivity PoSpecies Glossary
Applications WB, ICC/IF, IHC
Clone
1.7
Clonality
Monoclonal
Host
Mouse
Conjugate
FITC

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
NBP1-41050AF350
Alexa Fluor 405
NBP1-41050AF405
Alexa Fluor 488
NBP1-41050AF488
Alexa Fluor 532
NBP1-41050AF532
Alexa Fluor 594
NBP1-41050AF594
Alexa Fluor 647
NBP1-41050AF647
Alexa Fluor 700
NBP1-41050AF700
Alexa Fluor 750
NBP1-41050AF750
Biotin
NBP1-41050B
DyLight 350
NBP1-41050UV
DyLight 405
NBP1-41050V
DyLight 488
NBP1-41050G
DyLight 550
NBP1-41050R
DyLight 594
NBP1-41050DL594
DyLight 650
NBP1-41050C
DyLight 680
NBP1-41050FR
DyLight 755
NBP1-41050IR
HRP
NBP1-41050H
Janelia Fluor 549
NBP1-41050JF549
Janelia Fluor 646
NBP1-41050JF646
Unconjugated
NBP1-41050
View Available Formulations
Catalog# & Formulation Size Price
Standard Formulation
NBP1-41050
BSA Free
NBP1-41050
BSA Free
NBP1-41050-0.025mg
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SP-D Antibody (1.7) [FITC] Summary

Immunogen
Purified porcine surfactant protein D
Specificity
This antibody detects porcine surfactant protein D (pSP-D), a 138kD member of the collectin family of proteins. Surfactant protein D is thought to play a significant role in the innate immune response against microorganisms within the lungs and at other mucosal surfaces. SP-D is a multifunctional protein which binds selectively to saccharides and lipids on microbial surfaces promoting antimicrobial responses and regulating surfactant lipid homeostasis. SP-D expression is induced in lung surfactant in response to aerogenous bacterial infection, and upon binding to bacteria, promotes phagocytosis and antigen presentation by dendritic cells. Recent studies suggest that pSP-D could serve as a serum biomarker specific for bronchopneumonia in pigs.
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
SFTPD
Purity
Protein G purified
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Applications/Dilutions

Dilutions
  • Immunocytochemistry/ Immunofluorescence
  • Immunohistochemistry
  • Immunohistochemistry-Frozen
  • Immunohistochemistry-Paraffin
  • Western Blot
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Reactivity Notes

Mouse reactivity reported in scientific literature (PMID: 26092997).

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
PBS
Preservative
0.05% Sodium Azide
Purity
Protein G purified

Alternate Names for SP-D Antibody (1.7) [FITC]

  • COLEC7collectin-7
  • Collectin 7
  • Collectin-7
  • Lung surfactant protein D
  • PSPD
  • PSP-D
  • SFTP4
  • SFTP4pulmonary surfactant-associated protein D
  • SFTPD
  • SPD
  • SP-D
  • SP-Dpulmonary surfactant apoprotein
  • surfactant protein D
  • surfactant, pulmonary-associated protein D
  • surfactant-associated protein, pulmonary 4

Background

Surfactant protein D (SP-D) is synthesized and secreted by lung epithelial cells. It belongs to group III of the family of C-type lectins and members of this group has overall structure consisting of multiple globular head regions linked by triple-helical, collagen-like, strands. This group also includes SP-A and the serum proteins mannan-binding protein, conglutinin and collectin-43, all of which have been shown to bind to the C1q receptor found on a wide variety of cells. Both SP-D and SP-A have been shown to enhance oxygen radical production by alveolar macrophages. The serum concentration is 88 ng/ml in healthy individuals (2).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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SP-D Antibody
(1.7) [FITC]
NBP1-41050F
SP-D Antibody (1.7) [FITC]
Species: Po
Applications: WB, ICC/IF, IHC

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Bioinformatics

Gene Symbol SFTPD