Somatostatin R5/SSTR5 Antibody

Somatostatin Receptor Type 5 (SSTR5) has been reported to be expressed in adrenal, aorta, brain, breast, eye, heart, pancreas, prostate, skeletal muscle, small intestine, and thyroid. ESTs have been isolated from cartilage libraries. G-protein Coupled Receptors (GPCRs) comprise one of the largest families of signaling molecules with more than a thousand members currently predicted to exist. All GPCRs share a structural motif consisting of seven membrane-spanning helices, and exist in both active and inactive forms. An array of activating ligands participate in the conformation of GPCRs which leads to signaling via G-proteins and downstream effectors. Ongoing studies have also shown the vast series of reactions which participate in the negative regulation of GPCRs. This "turn-off" activity has tremendous implications for the physiological action of the cell, and continues to drive pharmacological research for new drug candidates. Two blockbuster drugs which have been developed as GPCR-targeted pharmaceuticals are Zyprexa (Eli Lilly) and Claritin (Schering-Plough) which have multi-billion dollar shares of the mental health and allergy markets, respectively

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 3 confirmed species: Human, Mouse, Porcine.

We have publications tested in 3 applications: FLOW, ICC/IF, WB.

Showing Publications 1 - 3 of 3.

Publications using NB100-74540	Applications	Species
Mandriani B, Pellè E, Mannavola F et al. Development of anti-somatostatin receptors CAR T cells for treatment of neuroendocrine tumors Journal for immunotherapy of cancer 2022-06-01 [PMID: 35764366] (FLOW, ICC/IF, Human)	FLOW, ICC/IF	Human
Jana B, Calka J, Czajkowska M The role of somatostatin and its receptors (sstr2, sstr5) in the contractility of gilt inflamed uterus Research in veterinary science 2020-09-19 [PMID: 33002813] (WB, Porcine)	WB	Porcine
Chung WY, Han JW, Heo W, Lee MG. Overexpression of WNK1 in POMC-expressing neurons reduces weigh gain via WNK4-mediated degradation of Kir6.2. Mol. Cell. Biochem. 2018-02-01 [PMID: 29392534] (Mouse)		Mouse

Array NB100-74540

• Somatostatin R5/SSTR5 Antibodies
• Somatostatin R5/SSTR5 ELISA Kit
• Somatostatin R5/SSTR5 Protein