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Somatostatin Antibody (YC7)

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications IHC
Clone
YC7
Clonality
Monoclonal
Host
Rat
Conjugate
Unconjugated

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Somatostatin Antibody (YC7) Summary

Immunogen
Somatostatin conjugated to thyroglobulin
Localization
Secreted
Specificity
NB100-64650 is specific for somatostatin. A hormone involved in endocrine system regulation through interactions with pituitary growth hormone, thyroid stimulating hormone, and a number of hormones of the gastrointestinal tract. Somatostatin has active 14 amino acid and 28 amino acid forms, produced by alternate cleavage of the gene product.This antibody does not cross react with enkephalins, other endorphins, substance P, or CGRP. It partially cross reacts with somatostatin fragments. The epitope recognized by this antibody lies within the 1-14 amino acid sequence of cyclic somatostatin.
Isotype
IgG2b
Clonality
Monoclonal
Host
Rat
Gene
SST
Purity
Tissue culture supernatant
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Applications/Dilutions

Dilutions
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Frozen 1:10-1:500
  • Immunohistochemistry-Paraffin 1:10-1:500
Publications
Read Publications using
NB100-64650 in the following applications:

Reactivity Notes

Predicted cross-reactivities: Porcine, Mouse, Guinea Pig, Rat, Zebrafish

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
Tissue culture supernatant
Preservative
0.09% Sodium Azide
Purity
Tissue culture supernatant

Alternate Names for Somatostatin Antibody (YC7)

  • Growth hormone release-inhibiting factor
  • SMST
  • SOM
  • Somatostatin
  • somatostatin-14
  • somatostatin-28
  • SRIF
  • SST

Background

The cyclic tetradecapeptide somatostatin is widely distributed throughout the body and is an important regulator of endocrine and nervous system function. It exerts its biologic actions by binding to specific high affinity receptors on the cell surface. Somatostatin inhibits the release of somatotropin. Somatostatin has also been shown in sympathetic nerves, mucosal cells, myenteric nerves of the gastrointestinal tract, salivary glands and in some parafollicular cells of the thyroid. Somatostatin positive cells may also be present in medullary thyroid carcinomas, C cell hyperplasia, thymic and lung tumors and pulmonary small cell carcinomas.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause reproductive toxicity with developmental effects.  For more information go to www.P65Warnings.ca.gov.

Publications for Somatostatin Antibody (NB100-64650)(5)

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 2 applications: IF/IHC, IHC-FrFl.


Filter By Application
IF/IHC
(1)
IHC-FrFl
(2)
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Mouse
(4)
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Showing Publications 1 - 5 of 5.
Publications using NB100-64650 Applications Species
Apaolaza PS, Chen YC, Grewal K et al. Quantitative analysis of islet prohormone convertase 1/3 expression in human pancreas donors with diabetes. Diabetologia 2024-10-15 [PMID: 39404844]
Martinez-Losa M, Tracy TE, Ma K et al. Nav1.1-Overexpressing Interneuron Transplants Restore Brain Rhythms and Cognition in a Mouse Model of Alzheimer's Disease. Neuron. 2018-03-15 [PMID: 29551491] (Mouse) Mouse
Rodriguez-Martinez D, Martinez-Losa MM, Alvarez-Dolado M. Cryopreservation of GABAergic Neuronal Precursors for Cell-Based Therapy PLoS ONE 2017-01-25 [PMID: 28122047] (IF/IHC, Mouse) IF/IHC Mouse
Milstead R, Link C, Xu Z, Hoeffer C Molecular Signaling and Neural Cell Type Expression of Complex Brain Disorders Thesis Jul 13 1905 (IHC-FrFl, Mouse) IHC-FrFl Mouse
Milstead R, Link C, Xu Z, Hoeffer C Molecular Signaling and Neural Cell Type Expression of Complex Brain Disorders Thesis 1905-07-13 (IHC-FrFl, Mouse) IHC-FrFl Mouse

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Secondary Antibodies

 

Isotype Controls

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Jamshed Arslan, Pharm D, PhD The dorsal root ganglia (DRG) are a collection of cell bodies of sensory nerves carrying sensory information – including nociception, mechanoreception and proprioception – from periphera...  Read full blog post.
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Bioinformatics

Gene Symbol SST
Entrez
Uniprot