Immunohistochemistry-Paraffin: Siglec-1/CD169 Antibody [NBP2-30903] - Staining of human placenta shows strong membranous positivity in Hofbauer cells.
Immunohistochemistry-Paraffin: Siglec-1/CD169 Antibody [NBP2-30903] - Staining of human lung shows strong membranous positivity in macrophages.
Immunohistochemistry-Paraffin: Siglec-1/CD169 Antibody [NBP2-30903] - Staining of human liver shows strong membranous positivity in Kupffer cells.
Immunohistochemistry-Paraffin: Siglec-1/CD169 Antibody [NBP2-30903] - Staining of human pancreas shows no positivity in exocrine glandular cells as expected.
This antibody was developed against a recombinant protein corresponding to amino acids: CTAQNLLGSISTIGRLQVEGARVVAEPGLDVPEGAALNLSCRLLGGPGPVGNSTFAWFWNDRRLHAEPVPTLAFTHVARAQAGMYH
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
SIGLEC1
Purity
Immunogen affinity purified
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The siglecs are a family of membrane bound lectins (of the immunoglobulin superfamily) that bind sialic acid and mediate cell-cell interactions. Family members include sialoadhesin, CD22 and CD33. Sialoadhesin is a macrophage-specific cell adhesion molecule that is expressed on activated macrophages in chronic inflammation and in tumours.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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