RPL7 Antibody

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L30P family of ribosomal proteins. It contains an N-terminal basic region-leucine zipper (BZIP)-like domain and the RNP consensus submotif RNP2. In vitro the BZIP-like domain mediates homodimerization and stable binding to DNA and RNA, with a preference for 28S rRNA and mRNA. The protein can inhibit cell-free translation of mRNAs, suggesting that it plays a regulatory role in the translation apparatus. It is located in the cytoplasm. The protein has been shown to be an autoantigen in patients with systemic autoimmune diseases, such as systemic lupus erythematosus. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 3 applications: IP, KD, WB.

Showing Publications 1 - 9 of 9.

Publications using NB100-2269	Applications	Species
Schatton D, Di Pietro G, Szczepanowska K et al. CLUH controls astrin-1 expression to couple mitochondrial metabolism to cell cycle progression eLife 2022-05-13 [PMID: 35559794]
Good, AL;Cannon, CE;Haemmerle, MW;Yang, J;Stanescu, DE;Doliba, NM;Birnbaum, MJ;Stoffers, DA; JUND regulates pancreatic beta cell survival during metabolic stress Mol Metab 2019-04-11 [PMID: 31023625] (WB, Mouse)	WB	Mouse
MacNair L, Xiao S, Miletic D et al. MTHFSD and DDX58 are novel RNA-binding proteins abnormally regulated in amyotrophic lateral sclerosis. Brain. 2015-11-02 [PMID: 26525917] (WB)	WB
Gao J, Schatton D, Martinelli P et al. CLUH regulates mitochondrial biogenesis by binding mRnAs of nuclear-encoded mitochondrial proteins. CLUH regulates mitochondrial biogenesis by binding mRnAs of nuclear-encoded mitochondrial proteins. 2014-10-27 [PMID: 25349259] (WB, Human, Mouse)	WB	Human, Mouse
Sanchez G, Dury AY, Murray LM et al. A novel function for the survival motoneuron protein as a translational regulator Hum Mol Genet 2012-11-21 [PMID: 23136128] (WB, Human)	WB	Human
El Fatimy R, Tremblay S, Dury AY et al. Fragile Mental Retardation Protein Interacts with the RNA-Binding Protein Caprin1 in Neuronal RiboNucleoProtein Complexes PLoS One 2012-01-01 [PMID: 22737234] (WB, Mouse)	WB	Mouse
Bae H, Gray JS, Li M et al. Hematopoietic cell kinase associates with the 40S ribosomal subunit and mediates the ribotoxic stress response to deoxynivalenol in mononuclear phagocytes. Toxicol Sci 2010-06-01 [PMID: 20181660]
Amorim MJ, Mata J. Rng3, a member of the UCS family of myosin co-chaperones, associates with myosin heavy chains cotranslationally. EMBO Rep 2009-02-01 [PMID: 19098712]
Good AL Unraveling The Beta Cell Translatome: Elucidation Of An Erk/hnrnpk/jund Axis Thesis (WB, KD, IP, Mouse, Human)	WB, KD, IP	Mouse, Human

Images	Ratings	Applications	Species	Date	Details
Enlarge	5 reviewed by: Sophia Zhang	WB	Mouse	03/28/2014	View Summary Application Western Blot Sample Tested Muscle Species Mouse

Array NB100-2269

• RPL7 Antibodies
• RPL7 Proteins