Recombinant Rat OX40/TNFRSF4 Fc Chimera Protein, CF

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

OX40 (CD134; TNFRSF4) is a T cell co-stimulatory molecule of the TNF receptor superfamily that coordinates with other co-stimulators (CD28, CD40, CD30, CD27 and 4-1BB) to manage the activation of the immune response (1-3). Rat OX40 is a 50 kDa type I transmembrane glycoprotein with a 20 amino acid (aa) signal sequence, a 191 aa extracellular domain (ECD) that contains a cysteine-rich region, a 25 aa transmembrane segment, and a 36 aa cytoplasmic domain (4). The ECD of rat OX40 shares 90% and 63% sequence identity with the ECD of mouse and human OX40, respectively. OX40 is up-regulated on CD4⁺ and CD8⁺ T cells upon engagement of the TCR by antigen presenting cells along with co-stimulation by CD40-CD40 Ligand and CD28-B7 (5, 6). OX40 Ligand is primarily expressed on antigen presenting cells (5). OX40 Ligand engagement of OX40 on activated CD4⁺ T cells results in increased T cell survival, proliferation, and cytokine production. It also inhibits the conversion of effector T cells into immunosuppressive regulatory T cells (Tregs) and can promote the maintenance of and recall response in memory T cells (3, 7-10). OX40 is constitutively expressed on Tregs and enhances the sensitivity of Tregs to IL-2, thus promoting Treg proliferation. OX40 has also been shown to decrease the cells’ immunosuppressive activity on effector T cells (11-14). OX40-OX40 Ligand signaling is involved in allergic airway inflammation, graft-versus-host disease and autoimmune disease (6, 15, 16). Mutations in OX40 and OX40 Ligand are associated with cardiovascular disease (17, 18).

Array 8584-OX

• OX40/TNFRSF4 Antibodies
• OX40/TNFRSF4 ELISA Kit
• OX40/TNFRSF4 Lysate
• OX40/TNFRSF4 ELISA
• OX40/TNFRSF4 Proteins and Enzymes