Recombinant Mouse Thrombospondin-1 Protein, CF

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Thrombospondin‑1 (TSP‑1) is a 150‑180 kDa calcium‑sensitive protein that is secreted as a disulfide‑linked homotrimer. Within the Thrombospondin family, TSP‑2 is also homotrimeric, while TSP-3, -4, and -5/COMP are pentameric. TSP‑1 regulates a wide range of cellular functions including their interactions with other cells and with the extracellular matrix (ECM). TSP-1 contains an N‑terminal Laminin G‑like globular domain, an extended central region with one vWF‑C domain, 3 TSP type 1 repeats, 3 EGF‑like domains, and 8 TSP type‑3 repeats, and a globular C‑terminal lectin domain. Distinct regions of TSP‑1 have been associated with binding to particular ECM or cellular molecules (1, 2). Mature mouse TSP‑1 shares 95% and 99% amino acid sequence identity with human and rat TSP‑1, respectively. TSP‑1 counteracts the angiogenic, hypotensive, and anti‑thrombotic effects of nitric oxide (NO) (3). It binds and neutralizes VEGF, blocks VEGF R2 signaling on vascular endothelial cells (EC), and destabilizes adhesive contacts between EC (4‑6). TSP‑1’s actions on vascular smooth muscle cells support arterial tone and blood pressure in the presence of vasodilatory stimulation (7). It is released from activated platelets and enhances platelet aggregation and adhesion (8). TSP-1 also plays an important role in wound repair and tissue fibrosis by binding latent TGF‑beta and inducing release of the active cytokine from the latency associated peptide (LAP) (9, 10). TSP‑1 dampens adaptive immune responses by inducing the differentiation of regulatory T cells and inhibiting TCR signaling (11, 12). In the nervous system, it promotes excitatory synapse formation (13, 14) and supports the integration of neural progenitor cells into the olfactory bulb (15). In addition, TSP‑1 is released by apoptotic cells and promotes macrophage-mediated debris clearance (16).

We have publications tested in 2 confirmed species: Mouse, Transgenic Mouse.

We have publications tested in 4 applications: Bioassay, ELISA Capture, In Vivo, Surface Plasmon Resonance (SPR.

Showing Publications 1 - 10 of 12. Show All 12 Publications. Collapse Publications.

Publications using 7859-TH	Applications	Species
Wilson, ZS;Raya-Sandino, A;Miranda, J;Fan, S;Brazil, JC;Quiros, M;Garcia-Hernandez, V;Liu, Q;Kim, CH;Hankenson, KD;Nusrat, A;Parkos, CA; Critical role of thrombospondin-1 in promoting intestinal mucosal wound repair JCI insight 2024-07-30 [PMID: 39078701] (Bioassay, Transgenic Mouse)	Bioassay	Transgenic Mouse
Andries, L;Kancheva, D;Masin, L;Scheyltjens, I;Van Hove, H;De Vlaminck, K;Bergmans, S;Claes, M;De Groef, L;Moons, L;Movahedi, K; Immune stimulation recruits a subset of pro-regenerative macrophages to the retina that promotes axonal regrowth of injured neurons Acta neuropathologica communications 2023-05-24 [PMID: 37226256] (In Vivo, Mouse)	In Vivo	Mouse
KW Southerlan, Y Xu, DT Peters, X Wei, X Lin, Y Xiang, K Fei, LA Olivere, JM Morowitz, J Otto, Q Dai, CD Kontos, Y Diao Pro-inflammatory macrophages impair skeletal muscle regeneration in ischemic-damaged limbs by inducing precocious differentiation of satellite cells bioRxiv : the preprint server for biology, 2023-04-03;0(0):. 2023-04-03 [PMID: 37066299] (Bioassay, Mouse)	Bioassay	Mouse
G Jacquemin, A Wurmser, M Huyghe, W Sun, Z Homayed, C Merle, M Perkins, F Qasrawi, S Richon, F Dingli, G Arras, D Loew, D Vignjevic, J Pannequin, S Fre Paracrine signalling between intestinal epithelial and tumour cells induces a regenerative programme Elife, 2022-05-11;11(0):. 2022-05-11 [PMID: 35543624] (Bioassay, Mouse)	Bioassay	Mouse
C He, B Jiang, M Wang, P Ren, SI Murtada, AW Caulk, G Li, L Qin, R Assi, CJ Lovoulos, MA Schwartz, JD Humphrey, G Tellides mTOR inhibition prevents angiotensin II-induced aortic rupture and pseudoaneurysm but promotes dissection in Apoe-deficient mice JCI Insight, 2022-02-08;7(3):. 2022-02-08 [PMID: 35132962] (Bioassay, Mouse)	Bioassay	Mouse
A Jeanne, T Sarazin, M Charlé, C Moali, C Fichel, C Boulagnon-, M Callewaert, MC Andry, E Diesis, F Delolme, D Rioult, S Dedieu Targeting Ovarian Carcinoma with TSP-1:CD47 Antagonist TAX2 Activates Anti-Tumor Immunity Cancers, 2021-10-07;13(19):. 2021-10-07 [PMID: 34638503] (Surface Plasmon Resonance (SPR, Mouse)	Surface Plasmon Resonance (SPR	Mouse
JB Conart, G Blot, S Augustin, G Millet-Pue, C Roubeix, F Beguier, H Charles-Me, S Touhami, JA Sahel, JP Berrod, T Léveillard, X Guillonnea, C Delarasse, F Sennlaub Insulin inhibits inflammation-induced cone death in retinal detachment J Neuroinflammation, 2020-11-26;17(1):358. 2020-11-26 [PMID: 33243251] (In Vivo, Mouse)	In Vivo	Mouse
NMP Cartee, MM Wang Binding of omeprazole to protein targets identified by monoclonal antibodies PLoS ONE, 2020-09-18;15(9):e0239464. 2020-09-18 [PMID: 32946534] (Mouse)		Mouse
F Wang, YH Liu, T Zhang, J Gao, Y Xu, GY Xie, WJ Zhao, H Wang, YG Yang Aging-associated changes in CD47 arrangement and interaction with thrombospondin-1 on red blood cells visualized by super-resolution imaging Aging Cell, 2020-08-31;0(0):e13224. 2020-08-31 [PMID: 32866348] (ELISA Capture, Mouse)	ELISA Capture	Mouse
Z Liu, Y Jiang, X Li, Z Hu Embryonic Stem Cell-Derived Peripheral Auditory Neurons Form Neural�Connections with Mouse Central Auditory Neurons In�Vitro via the�?2?1 Receptor Stem Cell Reports, 2018-06-07;0(0):. 2018-06-07 [PMID: 29887365] (Bioassay, Mouse)	Bioassay	Mouse
Thrombospondin-1 signaling through CD47 inhibits cell cycle progression and induces senescence in endothelial cells Cell Death Dis, 2016-09-08;7(9):e2368. 2016-09-08 [PMID: 27607583] (Bioassay, Mouse)	Bioassay	Mouse
Zheng Y, Zou F, Wang J, Yin G, Le V, Fei Z, Liu J Photodynamic therapy-mediated cancer vaccination enhances stem-like phenotype and immune escape, which can be blocked by thrombospondin-1 signaling through CD47 receptor protein. J Biol Chem, 2015-02-19;290(14):8975-86. 2015-02-19 [PMID: 25697354] (Bioassay, Mouse)	Bioassay	Mouse
Show All 12 Publications. Collapse Publications.

Array 7859-TH

• Thrombospondin-1 Antibodies
• Thrombospondin-1 ELISA Kits
• Thrombospondin-1 Lysate
• Thrombospondin-1 Protein
• Thrombospondin-1 ELISAs
• Thrombospondin-1 Proteins and Enzymes