Recombinant Mouse Proprotein Convertase 9/PCSK9 Protein, CF

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

PCSK9 (proprotein convertase subtilisin kexin 9), also known as NARC-1, is a member of the proteinase K subfamily of subtilisin-related serine endoproteases. It is highly expressed in the liver, intestine, and kidney and plays an important role in regulating LDL R expression and circulating cholesterol levels (1). PCSK9 is synthesized as precursor protein that is autocatalytically cleaved in the endoplasmic reticulum to generate a 14 kDa prodomain and a 60 kDa catalytic domain (2). Within the secretion pathway, the prodomain remains associated with and functions as a chaperone for the catalytic domain. Mouse PCSK9 shares 78% and 93% amino acid identity with human and rat PCSK9, respectively. PCSK9 plays a key role in the regulation of cholesterol metabolism by binding to hepatic LDL R, LRP-1, VLDL R, and Apolipoprotein E R2 and promoting their lysosomal degradation instead of recycling to the plasma membrane (3-8). It can also regulate cholesterol and triglyceride handling in the intestine and adipose tissue (9-11). The ability of PCSK9 to regulate LDL R expression is inhibited by its binding to LDL particles or Annexin A2 or by additional proteolytic cleavage (12-17).

We have publications tested in 3 confirmed species: Mouse, N/A, Primate - Macaca fascicularis (Cynomolgus Macaque).

We have publications tested in 2 applications: ELISA Capture, Western Blot.

Showing Publications 1 - 3 of 3.

Publications using 9258-SE	Applications	Species
Fowler, A;Van Rompay, KKA;Sampson, M;Leo, J;Watanabe, JK;Usachenko, JL;Immareddy, R;Lovato, DM;Schiller, JT;Remaley, AT;Chackerian, B; A Virus-like particle-based bivalent PCSK9 vaccine lowers LDL-cholesterol levels in Non-Human Primates bioRxiv : the preprint server for biology 2023-05-15 [PMID: 37292981] (ELISA Capture, Primate - Macaca fascicularis (Cynomolgus Macaque))	ELISA Capture	Primate - Macaca fascicularis (Cynomolgus Macaque)
D Pakalnišky, T Schönberge, B Strobel, B Stierstorf, T Lamla, M Schuler, M Lenter Rosa26-LSL-dCas9-VPR: a versatile mouse model for tissue specific and simultaneous activation of multiple genes for drug discovery Scientific Reports, 2022-11-10;12(1):19268. 2022-11-10 [PMID: 36357523] (Western Blot, N/A)	Western Blot	N/A
R Ibraheim, CQ Song, A Mir, N Amrani, W Xue, EJ Sontheimer All-in-one adeno-associated virus delivery and genome editing by Neisseria meningitidis Cas9 in vivo Genome Biol., 2018-09-19;19(1):137. 2018-09-19 [PMID: 30231914] (Western Blot, Mouse)	Western Blot	Mouse

Array 9258-SE

• Proprotein Convertase 9/PCSK9 Antibodies
• Proprotein Convertase 9/PCSK9 Antibody Pairs
• Proprotein Convertase 9/PCSK9 ELISA Kits
• Proprotein Convertase 9/PCSK9 Lysate
• Proprotein Convertase 9/PCSK9 Proteins and Enzymes
• Proprotein Convertase 9/PCSK9 ELISAs