Recombinant Mouse MMR/CD206 Protein, CF

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

The MMR (macrophage mannose receptor) is also called MR due to its presence on cells other than macrophages, and is designated CD206, Mrc1 (mannose receptor C type 1), or CLEC13D (C‑type lectin domain family 13, member D) (1‑4). CD206 is a 175 kDa endocytic receptor that is expressed on M2 alternatively activated tissue macrophages including tumor‑associated macrophages (TAMs), inflammatory dendritic cells in selected lymphoid organs, and liver, splenic, lymphatic, and dermal microvascular endothelial cells (1, 2, 5‑8). The 1456 amino acid (aa) mouse CD206 precursor contains a signal sequence (19 aa), an extracellular domain (ECD) containing an N‑terminal cysteine‑rich domain, a fibronectin type II repeat, eight C‑type lectin domains (CTLDs), and several N‑glycosylation sites (1369 aa), a transmembrane segment and a short (47 aa) cytoplasmic domain (2‑4). Metalloproteinases can mediate the shedding of the soluble ECD (2). The mouse CD206 ECD shares 96% aa sequence identity with rat MR, and 83‑84% with human, equine, porcine and canine CD206. The cysteine-rich domain recognizes some pituitary hormones such as LH (luteinizing hormone/lutropin) and TSH (thyroid stimulating hormone/thyrotropin), chondroitin sulfates, and sulfated N‑acetylgalactosamines including sulfo‑Lewis^a and ‑Lewis^x (1, 7, 9). The FNII domain mediates Ca2⁺‑independent binding of collagens (2, 10). The CTLDs participate in Ca2⁺‑dependent recognition of branched sugars with terminal mannose, fucose or N‑acetylglucosamine that occur on many pathogenic microorganisms (7, 11). CD206 internalizes ligands in clathrin-coated vesicles, sorts them to phagosomes or early endosomes, and recycles to the cell surface (1, 6, 7). CD206 also promotes clearance of glycoproteins that promote allergy or ongoing inflammation, such as lysosomal hydrolases and myeloperoxidases (1, 2, 5‑7). It is involved in T cell polarization and production of pro‑ and anti‑inflammatory cytokines (1, 2). It facilitates peptide presentation on MHC II, and cross‑presentation on MHC I which is important for tumor immunogenicity (1, 2, 12). This function may be blocked by engagement of CD206 on TAMs by tumor mucins (8).

We have publications tested in 3 confirmed species: Mouse, N/A, Plant - Ricinus communis.

We have publications tested in 4 applications: Bioassay, IHC-Fr, Surface Plasmon Resonance, Surface Plasmon Resonance (SPR.

Showing Publications 1 - 6 of 6.

Publications using 2535-MM/CF	Applications	Species
B Mooney, FJ Torres-Vel, J Doering, DJ Ehrbar, NJ Mantis Sensitivity of Kupffer cells and liver sinusoidal endothelial cells to ricin toxin and ricin toxin-Ab complexes J. Leukoc. Biol., 2019-07-16;0(0):. 2019-07-16 [PMID: 31313388] (Bioassay, Plant - Ricinus communis)	Bioassay	Plant - Ricinus communis
K Shibaguchi, A Tamura, M Terauchi, M Matsumura, H Miura, N Yui Mannosylated Polyrotaxanes for Increasing Cellular Uptake Efficiency in Macrophages through Receptor-Mediated Endocytosis Molecules, 2019-01-26;24(3):. 2019-01-26 [PMID: 30691115] (Surface Plasmon Resonance, Surface Plasmon Resonance (SPR, N/A)	Surface Plasmon Resonance, Surface Plasmon Resonance (SPR	N/A
K Subramania, DR Neill, HA Malak, L Spelmink, S Khandaker, G Dalla Libe, E Dearing, A Kirby, M Yang, A Achour, J Nilvebrant, PÅ Nygren, L Plant, A Kadioglu, B Henriques- Pneumolysin binds to the mannose receptor C type 1 (MRC-1) leading to anti-inflammatory responses and enhanced pneumococcal survival Nat Microbiol, 2018-11-12;0(0):. 2018-11-12 [PMID: 30420782] (Bioassay, Mouse)	Bioassay	Mouse
P Scodeller, L Simón-Grac, S Kopanchuk, A Tobi, K Kilk, P Säälik, K Kurm, ML Squadrito, VR Kotamraju, A Rinken, M De Palma, E Ruoslahti, T Teesalu Precision Targeting of Tumor Macrophages with a CD206 Binding Peptide Sci Rep, 2017-11-07;7(1):14655. 2017-11-07 [PMID: 29116108] (Bioassay, Mouse)	Bioassay	Mouse
Correction: A chitin-like component on sclerotic cells of fonsecaea pedrosoi inhibits dectin-1-mediated murine Th17 development by masking beta-glucans. PLoS ONE, 2015-03-18;10(3):e0119244. 2015-03-18 [PMID: 25786219] (Bioassay, Mouse)	Bioassay	Mouse
Green RS, Stone EL, Tenno M, Lehtonen E, Farquhar MG, Marth JD Mammalian N-glycan branching protects against innate immune self-recognition and inflammation in autoimmune disease pathogenesis. Immunity, 2007-08-02;27(2):308-20. 2007-08-02 [PMID: 17681821] (IHC-Fr, Mouse)	IHC-Fr	Mouse

Array 2535-MM/CF

• MMR/CD206/Mannose Receptor Antibodies
• MMR/CD206/Mannose Receptor ELISA Kits
• MMR/CD206/Mannose Receptor Proteins
• MMR/CD206/Mannose Receptor Proteins and Enzymes