Recombinant Mouse FABP4/A-FABP Protein, CF

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Fatty acid binding protein-4 (FABP4; also named A- (adipocyte) FABP, ALBP, or adipocyte protein 2 (aP2)) is a member of a large superfamily of lipid binding proteins that are expressed in a tissue specific manner (1, 5, 6). FABP4 is one of ten cytoplasmic FABPs that are 14-15 kDa in size and range from 126-140 amino acids (aa) in length (1, 2, 3). Although all are highly conserved in their tertiary structure, there is only modest aa identity between any two members. The FABP family members are subdivided based on organ or tissue type it was originally expressed or identified; liver- (L-FABP), intestine- (I-FABP), heart- (H-FABP), adipocyte- (A-FABP), epidermal- (E-FABP), ileal- (Il-FABP), brain- (B-FABP), myelin- (M-FABP) and testis-FABP (T-FABP) (1). Mouse A- FABP, the product of the FABP4 gene, is a 132 aa cytosolic protein that shows a flattened beta -barrel structure generated by a series of antiparallel beta -strands and two alpha ‑helices (4, 8). FABP4 is able to bind long-chain fatty acids, retinoic acids or eicosanoids with one mol of ligand bound per mole of protein (1, 8, 9). It is suggested that ligands first bind to the outside of the molecule, and this binding subsequently induces a conformational change in the binding protein, resulting in "internalization" of the ligand (4, 7, 9). Mouse FABP4 is 92%, 94% and 91% aa identical to human, rat and canine FABP4, respectively. It also shows 26% and 28% aa identity to mouse L-FABP and I‑FABP, respectively.

Array 9480-CL

• FABP4/A-FABP Antibodies
• FABP4/A-FABP ELISA Kits
• FABP4/A-FABP Lysate
• FABP4/A-FABP Proteins
• FABP4/A-FABP Proteins and Enzyme
• FABP4/A-FABP ELISAs