Recombinant Mouse CCL25/TECK Protein

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

CCL25, also known as TECK (thymus-expressed chemokine), is a CC chemokine that regulates the trafficking of lymphocytes in the thymus and small intestine. Mature mouse CCL25 shares 40% and 81% amino acid sequence identity with human and rat CCL25, respectively (1). CCL25 is produced by stromal cells in the thymus and epithelial cells of the small intestine, particularly the jejunum and ileum (1-3). It binds to and induces chemoattraction through CCR9 (1, 4, 5), and both human and mouse proteins act on human CCR9 (4). CCR9 is expressed on immature pre-T cells and thymocytes (5, 6). CCL25 induces the homing of several lymphocyte populations to the small intestine (3), including Integrin alpha 4 beta 7⁺ gamma δ T cells (6, 7), Integrin alpha E beta 7⁺ CD8⁺ T cells (8), and IgA-producing plasma cells (2). In cancer, functional CCR9 mediates the metastasis of melanoma cells to the small intestine (9), contributes to the CCL25-dependent migration and invasion of some breast carcinomas (10), and attracts mesenchymal stromal cells to CCL25-expressing multiple myelomas (11). CCL25 contributes to the severity of chronic inflammation in rheumatoid arthritis where it attracts CCR9⁺ monocytes and macrophages (12), in endometriosis where it promotes the invasiveness of stromal cells (13), and in atherosclerosis where it contributes to the accumulation of CCR9⁺ macrophages in arterial plaques (14).

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 2 applications: Bioassay, In Vivo.

Showing Publications 1 - 10 of 17. Show All 17 Publications. Collapse Publications.

Publications using 481-TK	Applications	Species
Ono, K;Sujino, T;Miyamoto, K;Harada, Y;Kojo, S;Yoshimatsu, Y;Tanemoto, S;Koda, Y;Zheng, J;Sayama, K;Koide, T;Teratani, T;Mikami, Y;Takabayashi, K;Nakamoto, N;Hosoe, N;London, M;Ogata, H;Mucida, D;Taniuchi, I;Kanai, T; Downregulation of chemokine receptor 9 facilitates CD4+CD8??+ intraepithelial lymphocyte development Nature communications 2023-08-24 [PMID: 37620389] (Bioassay, Mouse)	Bioassay	Mouse
C Li, HK Kim, P Prakhar, S Luo, A Crossman, DL Ligons, MA Luckey, P Awasthi, RE Gress, JH Park Chemokine receptor CCR9 suppresses the differentiation of CD4+CD8alphaalpha+ intraepithelial T cells in the gut Mucosal Immunology, 2022-07-01;0(0):. 2022-07-01 [PMID: 35778600] (Bioassay, Mouse)	Bioassay	Mouse
V Tereshchen, A Bulygin, R Zavodskii, A Maksyutov, V Kurilin, M Fisher, N Semenyuk, S Aladev, S Sennikov The murine DCs transfected with DNA-plasmid encoding CCR9 demonstrate the increased migration to CCL25 and thymic cells in vitro and to the thymus in vivo Cytokine, 2021-02-26;142(0):155473. 2021-02-26 [PMID: 33647585] (Bioassay, Mouse)	Bioassay	Mouse
H Zhang, Y Zheng, Y Pan, C Lin, S Wang, Z Yan, L Lu, G Ge, J Li, YA Zeng, J Chen A mutation that blocks integrin alpha4beta7 activation prevents adaptive immune-mediated colitis without increasing susceptibility to innate colitis BMC Biol., 2020-06-10;18(1):64. 2020-06-10 [PMID: 32522281] (Bioassay, Mouse)	Bioassay	Mouse
SM Pontejo, C Sanchez, B Ruiz-Argüe, A Alcami Insights into ligand binding by a viral tumor necrosis factor (TNF) decoy receptor yield a selective soluble human type 2 TNF receptor J. Biol. Chem., 2019-02-05;0(0):. 2019-02-05 [PMID: 30723161] (Bioassay, Mouse)	Bioassay	Mouse
FA Moretti, S Klapproth, R Ruppert, A Margraf, J Weber, R Pick, C Scheierman, M Sperandio, R Fässler, M Moser Differential requirement of kindlin-3 for T cell progenitor homing to the non-vascularized and vascularized thymus Elife, 2018-09-06;7(0):. 2018-09-06 [PMID: 30187863] (Bioassay, Mouse)	Bioassay	Mouse
S Shukla, MA Langley, J Singh, JM Edgar, M Mohtashami, JC Zúñiga-Pfl, PW Zandstra Progenitor T-cell differentiation from hematopoietic stem cells using Delta-like-4 and VCAM-1 Nat. Methods, 2017-04-10;14(5):531-538. 2017-04-10 [PMID: 28394335] (Bioassay, Mouse)	Bioassay	Mouse
Chen H, Sun J, Huang Z, Hou H, Arcilla M, Rakhilin N, Joe D, Choi J, Gadamsetty P, Milsom J, Nandakumar G, Longman R, Zhou X, Edwards R, Chen J, Chen K, Bu P, Wang L, Xu Y, Munroe R, Abratte C, Miller A, Gumus Z, Shuler M, Nishimura N, Edelmann W, Shen X, Lipkin S Comprehensive models of human primary and metastatic colorectal tumors in immunodeficient and immunocompetent mice by chemokine targeting. Nat Biotechnol, 2015-05-25;33(6):656-60. 2015-05-25 [PMID: 26006007] (Bioassay, Human)	Bioassay	Human
Graham K, Zhang J, Lewen S, Burke T, Dang T, Zoudilova M, Sobel R, Butcher E, Zabel B A novel CMKLR1 small molecule antagonist suppresses CNS autoimmune inflammatory disease. PLoS ONE, 2014-12-01;9(12):e112925. 2014-12-01 [PMID: 25437209] (Bioassay, Mouse)	Bioassay	Mouse
Miething , Corneliu, Scuoppo , Claudio, Bosbach , Benedikt, Appelmann , Iris, Nakitandwe , Joy, Ma , Jing, Wu , Gang, Lintault , Laura, Auer , Martina, Premsrirut , Prem K, Teruya-Feldstein , Julie, Hicks , James, Benveniste , Helene, Speicher , Michael, Downing , James R, Lowe , Scott W PTEN action in leukaemia dictated by the tissue microenvironment. Nature, 2014-05-04;510(7505):402-6. 2014-05-04 [PMID: 24805236] (Bioassay, Mouse)	Bioassay	Mouse
Costa MF, Bornstein VU, Candea AL, Henriques-Pons A, Henriques MG, Penido C CCL25 induces alpha 4 beta 7 integrin-dependent migration of IL-17+ gamma/delta T lymphocytes during an allergic reaction. Eur. J. Immunol., 2012-05-01;42(5):1250-60. 2012-05-01 [PMID: 22539297] (In Vivo, Mouse)	In Vivo	Mouse
McGuire HM, Vogelzang A, Ma CS, Hughes WE, Silveira PA, Tangye SG, Christ D, Fulcher D, Falcone M, King C A subset of interleukin-21+ chemokine receptor CCR9+ T helper cells target accessory organs of the digestive system in autoimmunity. Immunity, 2011-04-22;34(4):602-15. 2011-04-22 [PMID: 21511186] (Bioassay, Mouse)	Bioassay	Mouse
Penido C, Costa MF, Souza MC, Costa KA, Candea AL, Benjamim CF, Henriques MG Involvement of CC chemokines in gammadelta T lymphocyte trafficking during allergic inflammation: the role of CCL2/CCR2 pathway. Int. Immunol., 2007-12-04;20(1):129-39. 2007-12-04 [PMID: 18056919] (In Vivo, Mouse)	In Vivo	Mouse
Park EJ, Mora JR, Carman CV, Chen J, Sasaki Y, Cheng G, von Andrian UH, Shimaoka M Aberrant activation of integrin alpha4beta7 suppresses lymphocyte migration to the gut. J. Clin. Invest., 2007-09-01;117(9):2526-38. 2007-09-01 [PMID: 17786243] (Bioassay, Mouse)	Bioassay	Mouse
Kang SG, Lim HW, Andrisani OM, Broxmeyer HE, Kim CH Vitamin A metabolites induce gut-homing FoxP3+ regulatory T cells. J. Immunol., 2007-09-15;179(6):3724-33. 2007-09-15 [PMID: 17785809] (Bioassay, Mouse)	Bioassay	Mouse
Ueno T, Kuse S, Saito F, Nitta T, Kakiuchi T, Hollander GA, Takahama Y The role of CCL21 in recruitment of T-precursor cells to fetal thymi. Blood, 2004-09-09;105(1):31-9. 2004-09-09 [PMID: 15358618] (Bioassay, Mouse)	Bioassay	Mouse
Hieshima K, Kawasaki Y, Hanamoto H, Nakayama T, Nagakubo D, Kanamaru A, Yoshie O CC chemokine ligands 25 and 28 play essential roles in intestinal extravasation of IgA antibody-secreting cells. J. Immunol., 2004-09-15;173(6):3668-75. 2004-09-15 [PMID: 15356112] (Bioassay, Mouse)	Bioassay	Mouse
Show All 17 Publications. Collapse Publications.

Array 481-TK

• CCL25/TECK Antibodies
• CCL25/TECK ELISA Kit
• CCL25/TECK Lysate
• CCL25/TECK Proteins
• CCL25/TECK Proteins and Enzymes
• CCL25/TECK ELISAs