Recombinant Human LILRB1/CD85j/ILT2 His-tag Protein, CF

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

LILRB1, also known as CD85j and ILT2, is a 110 kDa transmembrane glycoprotein in the LILR immunoregulatory protein family (1). Mature human LILRB1 consists of a 438 amino acid (aa) extracellular domain (ECD) with 4 tandem Ig-like domains, a 21 aa transmembrane segment, and a 168 aa cytoplasmic domain with 4 inhibitory ITIM motifs (2). Alternative splicing generates an additional isoform that lacks the transmembrane and cytoplasmic regions (3). LILRB1 is expressed on the surface of B cells and monocytes, as well as subsets of NK cells, memory/effector CD8⁺ T cells, gamma δ T cells, and monocyte-derived dendritic cells (3-7). LILRB1 binds to MHC-I as well as non-classical MHC-I molecules (e.g. HLA-F, HLA-G, and HLA-B27) and the MHC-I mimetic UL18 encoded by cytomegalovirus (3, 5, 8-10). R&D Systems
in-house testing indicates that LILRB1 also binds to Angiopoietin-like 7. Ligation of LILRB1 inhibits the antigen induced proliferation and activation of CD8⁺ T cells, CD4⁺ T cells, NK cells, and gamma δ T cells (3, 4, 11-13). On dendritic cells, ligation inhibits the production of IL-10, IL-12p70, and TGF-beta and protects from Fas-mediated apoptosis (7).

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 2 applications: In Vivo, Reference Standard.

Showing Publications 1 - 2 of 2.

Publications using 8989-T2	Applications	Species
Tian, J;Ashique, AM;Weeks, S;Lan, T;Yang, H;Chen, HH;Song, C;Koyano, K;Mondal, K;Tsai, D;Cheung, I;Moshrefi, M;Kekatpure, A;Fan, B;Li, B;Qurashi, S;Rocha, L;Aguayo, J;Rodgers, C;Meza, M;Heeke, D;Medfisch, SM;Chu, C;Starck, S;Basak, NP;Sankaran, S;Malhotra, M;Crawley, S;Tran, TT;Duey, DY;Ho, C;Mikaelian, I;Liu, W;Rivera, LB;Huang, J;Paavola, KJ;O'Hollaren, K;Blum, LK;Lin, VY;Chen, P;Iyer, A;He, S;Roda, JM;Wang, Y;Sissons, J;Kutach, AK;Kaplan, DD;Stone, GW; ILT2 and ILT4 drive myeloid suppression via both overlapping and distinct mechanisms Cancer immunology research 2024-02-23 [PMID: 38393969] (In Vivo, Mouse)	In Vivo	Mouse
N Aggerholm-, HN Friis, T Baad-Hanse, HJ Møller, B Sandfeld-P Macrophage Biomarkers sCD163 and sSIRPalpha in Serum Predict Mortality in Sarcoma Patients Cancers, 2023-02-28;15(5):. 2023-02-28 [PMID: 36900335] (Reference Standard, Human)	Reference Standard	Human

Array 8989-T2

• ILT2/CD85j/LILRB1 Antibodies
• ILT2/CD85j/LILRB1 Lysate
• ILT2/CD85j/LILRB1 Proteins and Enzymes