Recombinant Human Contactin-6 Fc Chimera Protein, CF

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Contactin-6, also known as NB-3, is a 130 kDa member of the TAG/F3 subgroup of Contactin GPI‑linked neuronal adhesion proteins (1, 2). Mature human Contactin-6 consists of six immunoglobulin‑like domains (aa 26‑587), a flexible linker region, four fibronectin type III domains (aa 597‑992), and a GPI anchor (3). Within aa 20‑891, human Contactin-6 shares 89% aa sequence identity with mouse and rat Contactin-6. Contactin-6 expression is upregulated postnatally in the cerebellum, brainstem, and hippocampus, and it shows differential expression within various structures of the brain (3‑7). In the cerebellum, it is presynaptically localized at synapses between excitatory glutamatergic parallel fibers and Purkinje cells (7). Contactin-6 associates in cis with CHL-1, PTPR alpha, and PTPR gamma as well as in trans with Notch-1 on oligodendrocytes (6, 8‑10). Its binding to Notch-1 triggers the release and translocation of the Notch intracellular domain to the nucleus and promotes oligodendrogenesis (6). Contactin-6 function is important in the postnatal development and function of the cerebellum, as shown in knockout mice which exhibit poor motor coordination (5, 7).

Array 7394-CN

• Contactin-6 Antibodies
• Contactin-6 Lysate
• Contactin-6 Protein
• Contactin-6 Proteins and Enzymes