Recombinant Human CCL25/TECK Protein, CF

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

CCL25, also known as TECK (thymus-expressed chemokine), is a CC chemokine that regulates the trafficking of lymphocytes in the thymus and small intestine. Mature human CCL25 shares 40% amino acid sequence identity with mouse and rat CCL25 (1). CCL25 is produced by stromal cells in the thymus and epithelial cells of the small intestine, particularly the jejunum and ileum (1-3). It binds to and induces chemoattraction through CCR9 (1, 4, 5), and both human and mouse proteins act on human CCR9 (4). CCR9 is expressed on immature pre-T cells and thymocytes (5, 6). CCL25 induces the homing of several lymphocyte populations to the small intestine (3), including Integrin alpha 4 beta 7⁺ gamma δ T cells (6, 7), Integrin alpha E beta 7⁺ CD8⁺ T cells (8), and IgA-producing plasma cells (2). In cancer, functional CCR9 mediates the metastasis of melanoma cells to the small intestine (9), contributes to the CCL25-dependent migration and invasion of some breast carcinomas (10), and attracts mesenchymal stromal cells to CCL25-expressing multiple myelomas (11). CCL25 contributes to the severity of chronic inflammation in rheumatoid arthritis where it attracts CCR9⁺ monocytes and macrophages (12), in endometriosis where it promotes the invasiveness of stromal cells (13), and in atherosclerosis where it contributes to the accumulation of CCR9⁺ macrophages in arterial plaques (14).

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 1 application: Bioassay.

Showing Publications 1 - 3 of 3.

Publications using 9046-TK/CF	Applications	Species
S Chai, Z Wen, R Zhang, Y Bai, J Liu, J Li, W Kongling, W Chen, F Wang, L Gao CCL25/CCR9 interaction promotes the malignant behavior of salivary adenoid cystic carcinoma via the PI3K/AKT signaling pathway PeerJ, 2022-08-19;10(0):e13844. 2022-08-19 [PMID: 36003306] (Bioassay, Human, Mouse)	Bioassay	Human, Mouse
H Zhang, Y Zheng, Y Pan, C Lin, S Wang, Z Yan, L Lu, G Ge, J Li, YA Zeng, J Chen A mutation that blocks integrin alpha4beta7 activation prevents adaptive immune-mediated colitis without increasing susceptibility to innate colitis BMC Biol., 2020-06-10;18(1):64. 2020-06-10 [PMID: 32522281] (Bioassay, Human)	Bioassay	Human
L Wang, SS DeMarco, MS Peaks, AL Maiorana-B, J Chen, MJ Crouch, BM Shewchuk, SR Shaikh, CM Phillips, LC Bridges RAR?/RXR Synergism Potentiates Retinoid Responsiveness in Cutaneous T Cell Lymphoma Cell Lines Exp. Dermatol., 2017-07-03;0(0):. 2017-07-03 [PMID: 28370539] (Bioassay, Human)	Bioassay	Human

Array 9046-TK/CF

• CCL25/TECK Antibodies
• CCL25/TECK ELISA Kit
• CCL25/TECK Lysate
• CCL25/TECK Proteins
• CCL25/TECK ELISAs
• CCL25/TECK Proteins and Enzymes