Recombinant Human Annexin A1 Protein, CF

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

The Annexins comprise a family of proteins that are involved in many aspects of cellular membrane dynamics and the regulation of membrane‑associated proteins. They are characterized by multiple repeats of 60‑70 amino acids (aa) which assemble into a curved disc‑like domain that binds to membrane phospholipids in a calcium‑dependent manner (1). Human Annexin A1 (ANXA1), also known as Lipocortin 1, Calpactin II, Lipomodulin, and Chromobindin 9, contains four annexin repeats and shares approximately 88% aa sequence identity with mouse and rat Annexin A1 (2). Annexin A1 is found in the cytoplasm, on the cell surface, and in the extracellular fluid (3). The full length 37 kDa protein is susceptible to intracellular and extracellular proteolytic cleavages which generate various N‑terminal peptides and a truncated C‑terminal portion (3‑6). In addition to its membrane activities, Annexin A1 is a major effector of glucocorticoid‑induced immune suppression and growth arrest (7, 8). It associates with S100A11, and this complex inhibits Phospholipase A2 and the production of inflammatory eicosanoids (2, 4). Annexin A1 is released by apoptotic cells and also during neutrophil adhesion to vascular endothelial cells (3, 9). It binds the FPRL1/ALX receptor on neutrophils, while the cleaved N‑terminal aa 2‑26 peptide additionally binds FPR (10, 11). These interactions inhibit leukocyte activation and extravasation to sites of inflammation (3, 9, 10, 12). In contrast, the 33 kDa molecule (generated by the removal of aa 2‑26) promotes activation of vascular endothelial cells and neutrophil transendothelial migration (6). Annexin A1 phosphorylation at multiple locations is important for the regulation of its cleavage, membrane interactions, and ability to suppress ACTH production in the pituitary (4, 13, 14). Annexin A1 additionally regulates adaptive immune responses by enhancing T cell activation and promoting a Th1 bias (15). It can exert both positive and negative effects on epithelial‑mesenchymal transition and tumor metastasis (16‑18).

We have publications tested in 3 confirmed species: Human, Mouse, Vibrio cholerae.

We have publications tested in 2 applications: Bioassay, Cell Culture.

Showing Publications 1 - 6 of 6.

Publications using 3770-AN	Applications	Species
Nayer, B;Tan, JL;Alshoubaki, YK;Lu, YZ;Legrand, JMD;Lau, S;Hu, N;Park, AJ;Wang, XN;Amann-Zalcenstein, D;Hickey, PF;Wilson, T;Kuhn, GA;Müller, R;Vasanthakumar, A;Akira, S;Martino, MM; Local administration of regulatory T cells promotes tissue healing Nature communications 2024-09-09 [PMID: 39251592] (Bioassay, Mouse)	Bioassay	Mouse
O Zharkova, MF Salamah, MV Babak, E Rajan, LHK Lim, F Andrade, CD Gil, SM Oliani, LA Moraes, S Vaiyapuri Deletion of Annexin A1 in Mice Upregulates the Expression of Its Receptor, Fpr2/3, and Reactivity to the AnxA1 Mimetic Peptide in Platelets International Journal of Molecular Sciences, 2023-02-08;24(4):. 2023-02-08 [PMID: 36834844] (Bioassay, Mouse)	Bioassay	Mouse
H Alhasan, MA Terkawi, G Matsumae, T Ebata, Y Tian, T Shimizu, Y Nishida, S Yokota, F Garcia-Mar, M M Abd Elwa, D Takahashi, MA Younis, H Harashima, K Kadoya, N Iwasaki Inhibitory role of Annexin A1 in pathological bone resorption and therapeutic implications in periprosthetic osteolysis Oncogene, 2022-07-07;13(1):3919. 2022-07-07 [PMID: 35798730] (Bioassay, Human)	Bioassay	Human
A Zoued, H Zhang, T Zhang, RT Giorgio, CJ Kuehl, B Fakoya, B Sit, MK Waldor Proteomic analysis of the host-pathogen interface in experimental cholera Nature Chemical Biology, 2021-10-21;17(11):1199-1208. 2021-10-21 [PMID: 34675415] (Bioassay, Vibrio cholerae)	Bioassay	Vibrio cholerae
MA Rogers, F Buffolo, F Schlotter, SK Atkins, LH Lee, A Halu, MC Blaser, E Tsolaki, H Higashi, K Luther, G Daaboul, CVC Bouten, SC Body, SA Singh, S Bertazzo, P Libby, M Aikawa, E Aikawa Annexin A1-dependent tethering promotes extracellular vesicle aggregation revealed with single-extracellular vesicle analysis Science Advances, 2020-09-16;6(38):. 2020-09-16 [PMID: 32938681] (Bioassay, Cell Culture, Human)	Bioassay, Cell Culture	Human
RLG Maus, JW Jakub, WK Nevala, TA Christense, K Noble-Orcu, Z Sachs, TJ Hieken, SN Markovic Human Melanoma-Derived Extracellular Vesicles Regulate Dendritic Cell Maturation Front Immunol, 2017-03-29;8(0):358. 2017-03-29 [PMID: 28424693] (Bioassay, Human)	Bioassay	Human

Array 3770-AN

• Annexin A1 Antibodies
• Annexin A1 ELISA Kit
• Annexin A1 Lysate
• Annexin A1 Proteins
• Annexin A1 Proteins and Enzyme