Rat/Mouse Cytochrome c Quantikine ELISA Kit

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Cytochrome c is a small, highly conserved, heme-containing protein involved in mitochondrial electron transport. Cytochrome c is released from the mitochondria in response to pro-apoptotic stimuli and serves as a cofactor in initiating the activation of the APAF-1/Caspase-9 complex. The effect of specific proteins and/or small molecules on the initiation of the intrinsic apoptotic pathway can be evaluated in an in vitro system of isolated mitochondria by monitoring the release of cytochrome c.

We have publications tested in 3 confirmed species: Human, Mouse, Rat.

Showing Publications 1 - 10 of 35. Show All 35 Publications. Collapse Publications.

Publications using MCTC0	Applications	Species
Hamadi, N;Beegam, S;Zaaba, NE;Elzaki, O;Altamimi, MA;Nemmar, A; Neuroinflammation, Oxidative Stress, Apoptosis, Microgliosis and Astrogliosis in the Cerebellum of Mice Chronically Exposed to Waterpipe Smoke Biomedicines 2023-04-06 [PMID: 37189722] (Mouse)		Mouse
E Seydi, M Karbalay, S Naderpour, A Arjmand, J Pourahmad Cardiotoxicity of chloroquine and hydroxychloroquine through mitochondrial pathway Bmc Pharmacology & Toxicology, 2023-04-21;24(1):26. 2023-04-21 [PMID: 37085872] (Rat)		Rat
RM Salama, RH Ahmed, AA Farid, BA AbdElSatta, RM AbdelBaset, ME Youssef, SA El Wakeel Gastroprotective effect of dapagliflozin in ethanol-induced gastric lesions in rats: Crosstalk between HMGB1/RAGE/PTX3 and TLR4/MyD88/VEGF/PDGF signaling pathways International immunopharmacology, 2023-01-07;115(0):109686. 2023-01-07 [PMID: 36623411] (Rat)		Rat
AD Maguire, TN Friedman, DN Villarreal, F Haq, J Dunn, K Pfeifle, G Tenorio, K Buro, JR Plemel, BJ Kerr Sex differences in the inflammatory response of the mouse DRG and its connection to pain in experimental autoimmune encephalomyelitis Scientific Reports, 2022-12-05;12(1):20995. 2022-12-05 [PMID: 36470947] (Mouse)		Mouse
YH Cheah, CY Liu, BS Yip, CL Wu, KL Peng, JW Cheng Strategy to Enhance Anticancer Activity and Induced Immunogenic Cell Death of Antimicrobial Peptides by Using Non-Nature Amino Acid Substitutions Biomedicines, 2022-05-09;10(5):. 2022-05-09 [PMID: 35625834] (Human)		Human
CH Tsai, CT Pan, YY Chang, SY Peng, PC Lee, CW Liao, CT Shun, PT Li, VC Wu, CH Chou, IJ Tsai, CS Hung, YH Lin Aldosterone Excess Induced Mitochondria Decrease and Dysfunction via Mineralocorticoid Receptor and Oxidative Stress In Vitro and In Vivo Biomedicines, 2021-08-02;9(8):. 2021-08-02 [PMID: 34440149] (Rat)		Rat
NB Bloch, TE Wales, MS Prew, HR Levy, JR Engen, LD Walensky The conformational stability of pro-apoptotic BAX is dictated by discrete residues of the protein core Nature Communications, 2021-08-13;12(1):4932. 2021-08-13 [PMID: 34389733] (Mouse)		Mouse
W Lin, X Qian, LK Yang, J Zhu, D Wang, CH Hang, Y Wang, T Chen Inhibition of miR-134-5p protects against kainic acid-induced excitotoxicity through Sirt3-mediated preservation of mitochondrial function Epilepsy research, 2021-07-12;176(0):106722. 2021-07-12 [PMID: 34273723] (Mouse)		Mouse
AZ Spitz, E Zacharioud, DE Reyna, TP Garner, E Gavathioti Eltrombopag directly inhibits BAX and prevents cell death Nature Communications, 2021-02-18;12(1):1134. 2021-02-18 [PMID: 33602934] (Mouse)		Mouse
E Jangholi, ZN Sharifi, M Hoseinian, MR Zarrindast, HR Rahimi, A Mowla, H Aryan, MA Javidi, Y Parsa, F Ghaffarpas, S Yadollah-D, HZ Arani, F Shahi, S Movassaghi Verapamil Inhibits Mitochondria-Induced Reactive Oxygen Species and Dependent Apoptosis Pathways in Cerebral Transient Global Ischemia/Reperfusion Oxid Med Cell Longev, 2020-10-17;2020(0):5872645. 2020-10-17 [PMID: 33133347] (Rat)		Rat
MY Farrugia, M Caruana, S Ghio, A Camilleri, C Farrugia, RJ Cauchi, S Cappelli, F Chiti, N Vassallo Toxic oligomers of the amyloidogenic HypF-N protein form pores in mitochondrial membranes Sci Rep, 2020-10-20;10(1):17733. 2020-10-20 [PMID: 33082392] (Human)		Human
DT Cohen, TE Wales, MW McHenry, JR Engen, LD Walensky Site-Dependent Cysteine Lipidation Potentiates the Activation of Proapoptotic BAX Cell Rep, 2020-03-10;30(10):3229-3239.e6. 2020-03-10 [PMID: 32160532] (Mouse)		Mouse
IJ Tsai, WC Lin, YH Yang, YL Tseng, YH Lin, CH Chou, YK Tsau High Concentration of C5a-Induced Mitochondria-Dependent Apoptosis in Murine Kidney Endothelial Cells Int J Mol Sci, 2019-09-10;20(18):. 2019-09-10 [PMID: 31510052] (Mouse)		Mouse
P Naserzadeh, G Taghizadeh, B Atabaki, E Seydi, J Pourahmad A Comparison of Mitochondrial Toxicity of Mephedrone on three Separate Parts of Brain including Hippocampus, Cortex and Cerebellum Neurotoxicology, 2019-02-22;0(0):. 2019-02-22 [PMID: 30802467] (Rat)		Rat
J Shi, M Zhang, L Zhang, H Deng Epigallocatechin-3-gallate attenuates microcystin-LR-induced apoptosis in human umbilical vein endothelial cells through activation of the NRF2/HO-1 pathway Environ. Pollut., 2018-04-19;239(0):466-472. 2018-04-19 [PMID: 29679944] (Human)		Human
R Roshan, A Choudhary, A Bhambri, B Bakshi, T Ghosh, B Pillai microRNA dysregulation in polyglutamine toxicity of TATA-box�binding protein is mediated through STAT1 in mouse neuronal cells J Neuroinflammation, 2017-08-03;14(1):155. 2017-08-03 [PMID: 28774347] (Mouse)		Mouse
HM An, C Lin, C Gu, JJ Chen, WX Sun, M Jin, TL Zhang, MF Qiu, B Hu Di-Huang-Yi-Zhi herbal formula attenuates amyloid-?-induced neurotoxicity in PC12 cells Exp Ther Med, 2017-04-20;13(6):3003-3008. 2017-04-20 [PMID: 28587372] (Rat)		Rat
AA Fouad, HO Qutub, AEA Fouad, AM Audeh, WN Al-Melhim Epigallocatechin-3-gallate counters cisplatin toxicity of rat testes Pharm Biol, 2017-12-01;55(1):1710-1714. 2017-12-01 [PMID: 28478745] (Rat)		Rat
M Zhang, H Pan, Y Xu, X Wang, Z Qiu, L Jiang Allicin Decreases Lipopolysaccharide-Induced Oxidative Stress and Inflammation in Human Umbilical Vein Endothelial Cells through Suppression of Mitochondrial Dysfunction and Activation of Nrf2 Cell. Physiol. Biochem., 2017-04-26;41(6):2255-2267. 2017-04-26 [PMID: 28456799] (Human)		Human
X Niu, H Brahmbhatt, P Mergenthal, Z Zhang, J Sang, M Daude, FG Ehlert, WE Diederich, E Wong, W Zhu, J Pogmore, JP Nandy, M Satyanaray, RK Jimmidi, P Arya, B Leber, J Lin, C Culmsee, J Yi, DW Andrews A Small-Molecule Inhibitor of Bax and Bak Oligomerization Prevents Genotoxic Cell Death and Promotes Neuroprotection Cell Chem Biol, 2017-04-06;0(0):. 2017-04-06 [PMID: 28392146] (Mouse)		Mouse
F Kahrizi, A Salimi, F Noorbakhsh, M Faizi, F Mehri, P Naserzadeh, N Naderi, J Pourahmad Repeated Administration of Mercury Intensifies Brain Damage in Multiple Sclerosis through Mitochondrial Dysfunction Iran J Pharm Res, 2016-01-01;15(4):834-841. 2016-01-01 [PMID: 28243280] (Mouse)		Mouse
Lutz A, Sanwald J, Thomas M, Feuer R, Sawodny O, Ederer M, Borner C, Humar M, Merfort I Interleukin-1beta enhances FasL-induced caspase-3/-7 activity without increasing apoptosis in primary mouse hepatocytes. PLoS ONE, 2014-12-31;9(12):e115603. 2014-12-31 [PMID: 25551609] (Mouse)		Mouse
Dong H, Li R, Yu C, Xu T, Zhang X, Dong M Paeoniflorin inhibition of 6-hydroxydopamine-induced apoptosis in PC12 cells via suppressing reactive oxygen species-mediated PKCdelta/NF-kappaB pathway. Neuroscience, 2014-11-18;285(0):70-80. 2014-11-18 [PMID: 25446358] (Rat)		Rat
Dai , Shu-Hui, Chen , Tao, Wang , Yu-Hai, Zhu , Jie, Luo , Peng, Rao , Wei, Yang , Yue-Fan, Fei , Zhou, Jiang , Xiao-Fan Sirt3 protects cortical neurons against oxidative stress via regulating mitochondrial Ca2+ and mitochondrial biogenesis. Int J Mol Sci, 2014-08-21;15(8):14591-609. 2014-08-21 [PMID: 25196599] (Rat)		Rat
Ding J, Mooers B, Zhang Z, Kale J, Falcone D, McNichol J, Huang B, Zhang X, Xing C, Andrews D, Lin J After embedding in membranes antiapoptotic Bcl-XL protein binds both Bcl-2 homology region 3 and helix 1 of proapoptotic Bax protein to inhibit apoptotic mitochondrial permeabilization. J Biol Chem, 2014-03-10;289(17):11873-96. 2014-03-10 [PMID: 24616095] (Mouse)		Mouse
Tian , Ye, Li , Bin, Shi , Wen-Zhen, Chang , Ming-Ze, Zhang , Ge-Juan, Di , Zheng-Li, Liu , Yong Dynamin-related protein 1 inhibitors protect against ischemic toxicity through attenuating mitochondrial Ca2+ uptake from endoplasmic reticulum store in PC12 cells. Int J Mol Sci, 2014-02-21;15(2):3172-85. 2014-02-21 [PMID: 24566142] (Rat)		Rat
Li X, Chen W, Zhang L, Liu W, Fei Z Inhibition of store-operated calcium entry attenuates MPP(+)-induced oxidative stress via preservation of mitochondrial function in PC12 cells: involvement of Homer1a. PLoS ONE, 2013-12-17;8(12):e83638. 2013-12-17 [PMID: 24358303] (Rat)		Rat
Xu H, Luo P, Zhao Y, Zhao M, Yang Y, Chen T, Huo K, Han H, Fei Z Iduna protects HT22 cells from hydrogen peroxide-induced oxidative stress through interfering poly(ADP-ribose) polymerase-1-induced cell death (parthanatos). Cell Signal, 2013-01-16;25(4):1018-26. 2013-01-16 [PMID: 23333241] (Rat)		Rat
Clerc , Pascalin, Carey , Gregory, Mehrabian , Zara, Wei , Michael, Hwang , Hyehyun, Girnun , Geoffrey, Chen , Hegang, Martin , Stuart S, Polster , Brian M Rapid detection of an ABT-737-sensitive primed for death state in cells using microplate-based respirometry. PLoS ONE, 2012-08-03;7(8):e42487. 2012-08-03 [PMID: 22880001] (Mouse)		Mouse
Marchenko S, Chernyavsky AI, Arredondo J, Gindi V, Grando SA Antimitochondrial autoantibodies in pemphigus vulgaris: a missing link in disease pathophysiology. J. Biol. Chem., 2009-12-10;285(6):3695-704. 2009-12-10 [PMID: 20007702] (Mouse)		Mouse
Thirunavukkarasu C, Wang LF, Harvey SA, Watkins SC, Chaillet JR, Prelich J, Starzl TE, Gandhi CR Augmenter of liver regeneration: an important intracellular survival factor for hepatocytes. J. Hepatol., 2008-01-28;48(4):578-88. 2008-01-28 [PMID: 18272248] (Mouse)		Mouse
Dahm F, Bielawska A, Nocito A, Georgiev P, Szulc ZM, Bielawski J, Jochum W, Dindo D, Hannun YA, Clavien PA Mitochondrially targeted ceramide LCL-30 inhibits colorectal cancer in mice. Br. J. Cancer, 2007-11-20;98(1):98-105. 2007-11-20 [PMID: 18026195] (Mouse)		Mouse
Tanaka M, Nakae S, Terry RD, Mokhtari GK, Gunawan F, Balsam LB, Kaneda H, Kofidis T, Tsao PS, Robbins RC Cardiomyocyte-specific Bcl-2 overexpression attenuates ischemia-reperfusion injury, immune response during acute rejection, and graft coronary artery disease. Blood, 2004-07-27;104(12):3789-96. 2004-07-27 [PMID: 15280201] (Mouse)		Mouse
Jemmerson R, LaPlante B, Treeful A Release of intact, monomeric cytochrome c from apoptotic and necrotic cells. Cell Death Differ., 2002-05-01;9(5):538-48. 2002-05-01 [PMID: 11973612] (Mouse)		Mouse
Zha J, Weiler S, Oh KJ, Wei MC, Korsmeyer SJ Posttranslational N-myristoylation of BID as a molecular switch for targeting mitochondria and apoptosis. Science, 2000-12-01;290(5497):1761-5. 2000-12-01 [PMID: 11099414] (Mouse)		Mouse
Show All 35 Publications. Collapse Publications.

Array MCTC0

• Cytochrome c Antibodies
• Cytochrome c ELISA Kit
• Cytochrome c Lysate
• Cytochrome c ELISAs
• Cytochrome c Proteins and Enzyme