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PARC Antibody [Biotin]

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, IP
Clonality
Polyclonal
Host
Rabbit
Conjugate
Biotin

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
NB200-187AF350
Alexa Fluor 405
NB200-187AF405
Alexa Fluor 488
NB200-187AF488
Alexa Fluor 532
NB200-187AF532
Alexa Fluor 594
NB200-187AF594
Alexa Fluor 647
NB200-187AF647
Alexa Fluor 700
NB200-187AF700
Alexa Fluor 750
NB200-187AF750
Allophycocyanin
NB200-187APC
CoraFluor 1
NB200-187CL1
DyLight 350
NB200-187UV
DyLight 405
NB200-187V
DyLight 488
NB200-187G
DyLight 550
NB200-187R
DyLight 594
NB200-187DL594
DyLight 650
NB200-187C
DyLight 680
NB200-187FR
DyLight 755
NB200-187IR
FITC
NB200-187F
HRP
NB200-187H
Janelia Fluor 525
NB200-187JF525
Janelia Fluor 549
NB200-187JF549
Janelia Fluor 585
NB200-187JF585
Janelia Fluor 635
NB200-187JF635
Janelia Fluor 646
NB200-187JF646
Janelia Fluor 669
NB200-187JF669
PE
NB200-187PE
PerCP
NB200-187PCP
Unconjugated
NB200-187
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PARC Antibody [Biotin] Summary

Immunogen
A synthetic peptide, mapping to a region between residue 2475 and the C-terminus (residue 2527) of human P53-associated parkin-like cytoplasmic protein using the numbering given in TrEMBL entry Q8IWT3 (GeneID 23113).
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
CUL9
Purity
Immunogen affinity purified
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Applications/Dilutions

Dilutions
  • Immunoprecipitation
  • Western Blot
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
PBS
Preservative
0.05% Sodium Azide
Purity
Immunogen affinity purified

Alternate Names for PARC Antibody [Biotin]

  • CUL-9
  • cullin 9
  • cullin-9
  • DKFZp686G1042
  • H7AP1DKFZp686P2024
  • p53-associated parkin-like cytoplasmic protein
  • PARCKIAA0708
  • parkin-like cytoplasmic p53 binding protein
  • RP3-330M21.2
  • UbcH7-associated protein 1

Background

PARC is a cytoplasmic anchor protein in p53 associated protein complexes. PARC directly interacted and formed an approximately 1MD complex with p53 in the cytoplasm of unstressed cells. In the absence of stress, inactivation of PARC induced nuclear localization of endogenous p53 and activated p53 dependent apoptosis. Overexpression of PARC promoted cytoplasmic sequestration of ectopic p53. Furthermore, abnormal cytoplasmic localization of p53 was observed in a number of neuroblastoma cell lines; RNA interference-mediated reduction of endogenous PARC significantly sensitized these neuroblastoma cells in the DNA damage response. These results revealed that PARC is a critical regulator in controlling p53 subcellular localization and subsequent function.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol CUL9