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p57 Kip2 Antibody (KIP2/7187)

Images

 
IHC analysis of formalin-fixed, paraffin-embedded human complete mole (CM). Strong nuclear staining using p57 Kip2 antibody (KIP2/7187) at 2ug/ml in PBS for 30min RT.
IHC analysis of formalin-fixed, paraffin-embedded human placenta. Strong nuclear staining using p57 Kip2 antibody (KIP2/7187) at 2ug/ml in PBS for 30min RT. Inset: PBS instead of primary antibody; secondary only ...read more

Product Details

Summary
Reactivity Hu, MuSpecies Glossary
Applications IHC
Clone
KIP2/7187
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated
Concentration
0.2 mg/ml

Order Details

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p57 Kip2 Antibody (KIP2/7187) Summary

Description
Positive Controls: Raji, HT29 or SK-BR3 cells. Human colon or prostate carcinomas.

Antibody with azide - store at 2 to 8C. Antibody without azide - store at -20 to -80C. Non-hazardous. No MSDS required.
Immunogen
Recombinant full-length human p57 Kip2 protein
Localization
Nucleus.
Specificity
Recognizes a protein of 57kDa, identified as p57 Kip2 It shows no cross-reaction with p27Kip1
Isotype
IgG Kappa
Clonality
Monoclonal
Host
Mouse
Gene
CDKN1C
Purity
Protein A or G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunohistochemistry-Paraffin 0.25-0.5 ug/ml
Application Notes
Immunohistochemistry (Formalin-fixed): 0.25-0.5ug/ml for 30 minutes. at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95C followed by cooling at RT for 20 minutes.

Optimal dilution for a specific application should be determined.

Packaging, Storage & Formulations

Storage
Store at 4C. Do not freeze.
Buffer
10mM PBS with 0.05% BSA
Preservative
0.05% Sodium Azide
Concentration
0.2 mg/ml
Purity
Protein A or G purified

Alternate Names for p57 Kip2 Antibody (KIP2/7187)

  • Beckwith-Wiedemann syndrome
  • BWS
  • cyclin-dependent kinase inhibitor 1C (p57, Kip2)
  • cyclin-dependent kinase inhibitor 1C
  • Cyclin-dependent kinase inhibitor p57
  • KIP2BWCR
  • p57
  • p57Kip2
  • WBS

Background

p57kip2 is a tight-binding, strong inhibitor of several G1 cyclin/Cdk complexes and a negative regulator of cell proliferation. Mutations in this gene are implicated in sporadic cancers and Beckwith-Wiedemann syndorome, suggesting that this gene is a tumor suppressor candidate.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for p57 Kip2 Antibody (NBP3-20437) (0)

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FAQs for p57 Kip2 Antibody (NBP3-20437) (0)

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Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol CDKN1C