Oval Cell Marker Antibody (MIC1-1C3) - BSA Free

Liver is well known to possess facultative stem cells which can be activated in response to injury and hepatic stem cell activation was first described in rat model, wherein, chemical damage in combination with partial hepatectomy resulted in the emergence of a new cell type which was described according to its nuclear morphology as "oval cells". The word 'oval cells' is now employed to define population of small proliferating cells with oval-shaped nuclei which arise within liver tissue following certain types of hepatic injury. Oval cell proliferation is activated when the proliferative capacity of hepatocytes is impaired, as well as in certain models of carcinogenesis. Histologically, hepatic tissue is highly complex and contains many different cell types including various kinds of hepatocytes, ducts, hematopoietic cells, endothelial cells, macrophages, stellate cells etc., and the oval cells have been proposed to be bipotential progenitor cells capable of generating both hepatocytes and bile ducts. Due to their bipotency and high clonogenicity, oval cells have been considered putative liver stem cells and research is in progress for elucidation of signaling molecules involved in controlling the activation, proliferation and differentiation of this unique cell population. Our oval cell antibodies have been developed against hepatic nonparenchymal cells (NPCs) from mice undergoing oval cell activation and with these antibodies, it is now possible to perform microarray analysis of distinct liver cell populations during induced oval cell response or certain pathological conditions.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 4 applications: FLOW, ICC/IF, IHC-Fr, IHC-P.

Showing Publications 1 - 10 of 12. Show All 12 Publications. Collapse Publications.

Publications using NBP1-18961	Applications	Species
Krishnan, A;Ozturk, NB;Cutshaw, KA;Guicciardi, ME;Kitagataya, T;Olson, KE;Pavelko, KD;Sherman, W;Wixom, AQ;Jalan-Sakrikar, N;Baez-Faria, M;Gutierrez, F;Gores, GJ; Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) deletion in myeloid cells augments cholestatic liver injury Scientific reports 2024-01-25 [PMID: 38273071]
Tao Q, Ji H, Zhou Y et al. HDAC3 controls liver homeostasis more by facilitating DNA damage repair than by regulating transcription in hepatocytes Laboratory investigation; a journal of technical methods and pathology 2023-02-17 [PMID: 36801398] (IHC-P, Mouse)	IHC-P	Mouse
Beel S, Kolloch L, Apken LH et al. kappa B-Ras and Ral GTPases regulate acinar to ductal metaplasia during pancreatic adenocarcinoma development and pancreatitis Nat Commun 2020-07-08 [PMID: 32641778] (FLOW, Mouse)	FLOW	Mouse
Krishnan A, Katsumi T, Guicciardi ME et al. Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Receptor Deficiency Promotes the Ductular Reaction, Macrophage Accumulation, and Hepatic Fibrosis in the Mdr2-/- Mouse Am. J. Pathol. 2020-03-30 [PMID: 32240619] (Mouse)		Mouse
Tam PKH, Yiu RS, Lendahl U, Andersson ER. Cholangiopathies - Towards a molecular understanding. EBioMedicine 2018-09-01 [PMID: 30236451] (Mouse, Human)		Mouse, Human
Lu XF, Zhou YJ, Zhang L et al. Loss of Dicer1 impairs hepatocyte survival and leads to chronic inflammation and progenitor cell activation World J. Gastroenterol. 2015-06-07 [PMID: 26074697] (IHC-P, Mouse)	IHC-P	Mouse
Dorrell C, Tarlow B et al. The organoid-initiating cells in mouse pancreas and liver are phenotypically and functionally similar. Stem Cell Res 2014-01-09 [PMID: 25151611] (FLOW, Mouse)	FLOW	Mouse
Bird TG, Lu WY, Boulter L et al. Bone marrow injection stimulates hepatic ductular reactions in the absence of injury via macrophage-mediated TWEAK signaling Proc Natl Acad Sci U S A 2013-04-01 [PMID: 23576749] (IHC-P, ICC/IF, Mouse)	IHC-P, ICC/IF	Mouse
Dorrell C, Erker L, Schug J, Kopp JL, Canaday PS, Fox AJ, Smirnova O, Duncan AW, Finegold MJ, Sander M, Kaestner KH, Grompe M. Prospective isolation of a bipotential clonogenic liver progenitor cell in adult mice. . Genes Dev. 25(11):1193-203. doi: 10.1101/gad.2029411. 2011-06-01 [PMID: 21632826] (FLOW, Mouse)	FLOW	Mouse
Dorrell C, Grompe MT, Pan FC, Zhong Y, Canaday PS, Shultz LD, Greiner DL, Wright CV, Streeter PR, Grompe M. Isolation of mouse pancreatic alpha, beta, duct and acinar populations with cell surface markers. Mol Cell Endocrinol;339(1-2):144-50. 2011-06-06 [PMID: 21539888] (FLOW, Mouse)	FLOW	Mouse
Lu L, Li Y, Kim SM, Bossuyt W, Liu P, Qiu Q, Wang Y, Halder G, Finegold MJ, Lee JS, Johnson RL. Hippo signaling is a potent in vivo growth and tumor suppressor pathway in the mammalian liver. Proc Natl Acad Sci U S A;107(4):1437-42. 2010-01-26 [PMID: 20080689] (IHC-Fr, Mouse)	IHC-Fr	Mouse
Dorrell, C et al. Surface Markers for the Murine Oval Cell Response. Hepatology 48(0):1-10. 2008-01-01 [PMID: 18726953] (IHC-Fr, FLOW, Mouse)	IHC-Fr, FLOW	Mouse
Show All 12 Publications. Collapse Publications.

Images	Ratings	Applications	Species	Date	Details
	5 reviewed by: Verified Customer	IHC-Fr	Mouse	06/04/2021	View Summary Application Immunohistochemistry-Frozen Sample Tested Liver Species Mouse Lot 082718 Comments Comments Acetone fixation
	5 reviewed by: Bin Li	Flow	Mouse	12/06/2016	View Summary Application Flow Cytometry Sample Tested mouse liver NPC Species Mouse

Array NBP1-18961

• Oval Cell Marker Antibodies