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Osteoactivin/GPNMB Antibody (303822) [Janelia Fluor® 646]

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, CyTOF-ready, Flow, ICC/IF
Clone
303822
Clonality
Monoclonal
Host
Mouse
Conjugate
Janelia Fluor 646

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
FAB25501U-100UG
Alexa Fluor 405
FAB25501V-100UG
Alexa Fluor 488
FAB25501G-100UG
Alexa Fluor 532
FAB25501X
Alexa Fluor 594
FAB25501T-100UG
Alexa Fluor 647
FAB25501R-100UG
Alexa Fluor 700
FAB25501N-100UG
Alexa Fluor 750
FAB25501S-100UG
Allophycocyanin
FAB25501A
Biotin
FAB25501B
CoraFluor 1
FAB25501CL1
DyLight 350
FAB25501D
DyLight 405
FAB25501E
DyLight 488
FAB25501K
DyLight 550
FAB25501L
DyLight 594
FAB25501M
DyLight 650
FAB25501W
DyLight 680
FAB25501Y
DyLight 755
FAB25501Z
FITC
FAB25501F
HRP
FAB25501H
Janelia Fluor 525
FAB25501JF525
Janelia Fluor 549
FAB25501I
Janelia Fluor 635
FAB25501JF635
Janelia Fluor 669
FAB25501JF669
PE
FAB25501P
PerCP
FAB25501C
Unconjugated
MAB25501
mFluor Violet 450 SE
FAB25501MFV450
mFluor Violet 500 SE
FAB25501MFV500
mFluor Violet 610 SE
FAB25501MFV610
View Available Formulations
Catalog# & Formulation Size Price
Standard Formulation
MAB25501
Carrier Free
MAB25501
Carrier Free
MAB25501-SP
Carrier Free
FAB25501V-100UG
Carrier Free
FAB25501U-100UG
Carrier Free
FAB25501T-100UG
Carrier Free
FAB25501S-100UG
Carrier Free
FAB25501R-100UG
Carrier Free
FAB25501N-100UG
Carrier Free
FAB25501G-100UG
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Osteoactivin/GPNMB Antibody (303822) [Janelia Fluor® 646] Summary

Immunogen
Mouse myeloma cell line NS0-derived recombinant human Osteoactivin/GPNMB isoform 2
Ala22-Asn486
Accession # NP_002501
Specificity
Detects human Osteoactivin/GPNMB in direct ELISAs and Western blots. In direct ELISAs, no cross-reactivity with recombinant mouse Osteoactivin is observed.
Isotype
IgG2b
Clonality
Monoclonal
Host
Mouse
Gene
GPNMB
Purity
Protein A or G purified from hybridoma culture supernatant
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.
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Applications/Dilutions

Dilutions
  • CyTOF-ready
  • Immunocytochemistry
  • Intracellular Staining by Flow Cytometry
  • Western Blot
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Protein A or G purified from hybridoma culture supernatant

Notes

Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

Alternate Names for Osteoactivin/GPNMB Antibody (303822) [Janelia Fluor® 646]

  • DC-HIL
  • glycoprotein (transmembrane) nmb
  • glycoprotein NMB
  • GPNMB
  • HGFIN
  • HGFINglycoprotein nmb-like protein
  • NMBosteoactivin
  • Osteoactivin
  • Transmembrane glycoprotein HGFIN
  • transmembrane glycoprotein NMB

Background

The GPNMB gene codes for a type I transmembrane glycoprotein NBM. The GPNMB gene is present in lowly, but not highly, metastic human melanoma cell lines, therefore, it demonstrates involvement in development, proliferation, and differentiation of tissues. Isoform 1 is 572 amino acids long at a mass of nearly 64 kDA and isoform 2 exists at 560 amino acids long at approximately 62 kDA. This gene has been known to interact with various genes such as SMAD4, PLA2G4A, and ITSN2. GPNMB has been researched in its role in retinitis, lung cancer, melanoma, glioblastoma, glaucoma, and breast cancer.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol GPNMB