OSBPL2 Antibody

OSBPL2 encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain, although some members contain only the sterol-binding domain. This encoded protein contains only the sterol-binding domain. In vitro studies have shown that the encoded protein can bind strongly to phosphatic acid and weakly to phosphatidylinositol 3-phosphate, but cannot bind to 25-hydroxycholesterol. The protein associates with the Golgi apparatus. Transcript variants encoding different isoforms have been described.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 3 applications: ICC/IF, IP, WB.

Showing Publications 1 - 3 of 3.

Publications using NBP1-92236	Applications	Species
Koh yI, Oh KS, Kim JA et al. OSBPL2 mutations impair autophagy and lead to hearing loss, potentially remedied by rapamycin Autophagy 2022-03-06 [PMID: 35253614] (ICC/IF, WB, IP, Human)	ICC/IF, WB, IP	Human
Takahashi K, Kanerva K, Vanharanta L et al. ORP2 couples LDL-cholesterol transport to FAK activation by endosomal cholesterol/PI(4,5)P2 exchange The EMBO journal 2021-06-14 [PMID: 34124795]
Koponen A A Combined Model of Human iPSC Derived Liver Organoids and Hepatocytes Reveals Ferroptosis in DGUOK Mutant mtDNA Depletion Syndrome Adv Sci (Weinh) 2021-05-24 [PMID: 34026460]

Images	Ratings	Applications	Species	Date	Details
Enlarge	4 reviewed by: Verified Customer	WB	Human	04/15/2019	View Summary Application Western Blot Sample Tested Hela whole cell lysate Species Human Lot R37358 Comments Comments Primary antibody used at 1:1000 overnight at 4°C.

Array NBP1-92236

• OSBPL2 Antibodies
• OSBPL2 Lysates
• OSBPL2 Proteins