Mouse IL-23 DuoSet ELISA, 15 Plate

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

IL-23 (Interleukin-23) is a disulfide-linked cytokine composed of a p19 subunit that is unique to IL-23 and a p40 subunit that is shared with IL-12. It is produced by activated macrophages, microglia, and monocyte-derived dendritic cells in response to pathogens. IL-23 induces the earliest recruitment of neutrophils to the site of infection and promotes the development and maintenance of Th17 cells. It also enhances the development of Th17 mediated autoimmunity and tumor progression. IL-23 signals through a receptor complex consisting of IL-12 R beta 1 and IL-23 R. This complex is expressed in mouse Th1 and Th2 cells, bone marrow dendritic cells, activated macrophages and CD4+ CD45Rb(low) memory T cells.

We have publications tested in 3 confirmed species: Human, Mouse, Transgenic Mouse.

Showing Publications 1 - 10 of 26. Show All 26 Publications. Collapse Publications.

Publications using DY1887	Applications	Species
Zhu, W;Xu, X;Nagarajan, V;Guo, J;Peng, Z;Zhang, A;Liu, J;Mattapallil, MJ;Jittayasothorn, Y;Horai, R;Leger, AJS;Caspi, RR; TLR2 Supports ?? T cell IL-17A Response to ocular surface commensals by Metabolic Reprogramming bioRxiv : the preprint server for biology 2024-04-01 [PMID: 38712203] (Mouse)		Mouse
Heinzl, GC;Eriksen, DB;Johnsen, PR;Scarafoni, A;Frøkiær, H; Protein Concentration Affects the Food Allergen ?-Conglutin Uptake and Bacteria-Induced Cytokine Production in Dendritic Cells Biomolecules 2023-10-16 [PMID: 37892213] (Mouse)		Mouse
M Viladomiu, M Khounlotha, B Dogan, SF Lima, A Elsaadi, E Cardakli, JG Castellano, C Ng, J Herzog, AA Schoenborn, M Ellermann, B Liu, S Zhang, AS Gulati, RB Sartor, KW Simpson, SM Lipkin, RS Longman Agr2-associated ER stress promotes adherent-invasive E.�coli dysbiosis and triggers CD103+ dendritic cell IL-23-dependent ileocolitis Cell Reports, 2022-11-15;41(7):111637. 2022-11-15 [PMID: 36384110] (Mouse, Transgenic Mouse)		Mouse, Transgenic Mouse
KJ Smith, D Minns, BJ McHugh, RK Holloway, R O'Connor, A Williams, L Melrose, R McPherson, VE Miron, DJ Davidson, E Gwyer Find The antimicrobial peptide cathelicidin drives development of experimental autoimmune encephalomyelitis in mice by affecting Th17 differentiation PloS Biology, 2022-08-26;20(8):e3001554. 2022-08-26 [PMID: 36026478] (Mouse)		Mouse
J Hu, Y Zhang, S Yi, C Wang, X Huang, S Pan, J Yang, G Yuan, S Tan, H Li Lithocholic acid inhibits dendritic cell activation by reducing intracellular glutathione via TGR5 signaling International journal of biological sciences, 2022-07-11;18(11):4545-4559. 2022-07-11 [PMID: 35864954] (Mouse)		Mouse
M Arabpour, C Lebrero-Fe, K Schön, A Strömberg, V Börjesson, K Lahl, M Ballegeer, X Saelens, D Angeletti, W Agace, N Lycke ADP-ribosylating adjuvant reveals plasticity in cDC1 cells that drive mucosal Th17 cell development and protection against influenza virus infection Mucosal Immunology, 2022-04-13;0(0):. 2022-04-13 [PMID: 35418673] (Mouse)		Mouse
F Scopelliti, L Mercurio, C Cattani, V Dimartino, C Albanesi, G Costanzo, C Mirisola, S Madonna, A Cavani The phosphoinositide-3-kinase (PI3K)-delta inhibitor seletalisib impairs monocyte-derived dendritic cells maturation, APC function, and promotes their migration to CCR7 and CXCR4 ligands Journal of leukocyte biology, 2022-02-24;0(0):. 2022-02-24 [PMID: 35199885] (Mouse)		Mouse
J Hu, C Wang, X Huang, S Yi, S Pan, Y Zhang, G Yuan, Q Cao, X Ye, H Li Gut microbiota-mediated secondary bile acids regulate dendritic cells to attenuate autoimmune uveitis through TGR5 signaling Cell Reports, 2021-09-21;36(12):109726. 2021-09-21 [PMID: 34551302] (Mouse)		Mouse
J Munhoz, R Thomé, A Rostami, LLW Ishikawa, L Verinaud, C Rapôso The SNX-482 peptide from Hysterocrates gigas spider acts as an immunomodulatory molecule activating macrophages Peptides, 2021-09-16;146(0):170648. 2021-09-16 [PMID: 34537257] (Mouse)		Mouse
KJ Warren, JA Poole, JM Sweeter, JM DeVasure, JD Dickinson, RS Peebles, TA Wyatt Neutralization of IL-33 modifies the type 2 and type 3 inflammatory signature of viral induced asthma exacerbation Respiratory Research, 2021-07-15;22(1):206. 2021-07-15 [PMID: 34266437] (Mouse)		Mouse
K Ueno, Y Otani, N Yanagihara, M Urai, A Nagamori, M Sato-Fukus, K Shimizu, N Saito, Y Miyazaki Cryptococcus gattii evades CD11b-mediated fungal recognition by coating itself with capsular polysaccharides European Journal of Immunology, 2021-03-30;0(0):. 2021-03-30 [PMID: 33728652] (Mouse)		Mouse
J Jin, IH Jung, SH Moon, S Jeon, SJ Jeong, SK Sonn, S Seo, MN Lee, EJ Song, HY Kweon, S Kim, TK Kim, J Kim, HR Cho, JH Choi, B Kwon, GT Oh CD137 Signaling Regulates Acute Colitis via RALDH2-Expressing CD11b-CD103+ DCs Cell Rep, 2020-03-24;30(12):4124-4136.e5. 2020-03-24 [PMID: 32209473] (Mouse)		Mouse
AL Frisbee, MM Saleh, MK Young, JL Leslie, ME Simpson, MM Abhyankar, CA Cowardin, JZ Ma, P Pramoonjag, SD Turner, AP Liou, EL Buonomo, WA Petri IL-33 drives group 2 innate lymphoid cell-mediated protection during Clostridium difficile infection Nat Commun, 2019-06-20;10(1):2712. 2019-06-20 [PMID: 31221971] (Mouse)		Mouse
Targeting dendritic cells to accelerate T-cell activation overcomes a bottleneck in tuberculosis vaccine efficacy Nat Commun, 2016-12-22;7(0):13894. 2016-12-22 [PMID: 28004802] (Mouse)		Mouse
Transcriptional and functional characterization of CD137L-dendritic cells identifies a novel dendritic cell phenotype Sci Rep, 2016-07-19;6(0):29712. 2016-07-19 [PMID: 27431276] (Human)		Human
Brown A, Murphy A, Lalor S, Leech J, O'Keeffe K, Mac Aogain M, O'Halloran D, Lacey K, Tavakol M, Hearnden C, Fitzgerald-Hughes D, Humphreys H, Fennell J, van Wamel W, Foster T, Geoghegan J, Lavelle E, Rogers T, McLoughlin R Memory Th1 Cells Are Protective in Invasive Staphylococcus aureus Infection. PLoS Pathog, 2015-11-05;11(11):e1005226. 2015-11-05 [PMID: 26539822] (Mouse)		Mouse
Cowardin C, Kuehne S, Buonomo E, Marie C, Minton N, Petri W Inflammasome activation contributes to interleukin-23 production in response to Clostridium difficile. MBio, 2015-01-27;6(1):. 2015-01-27 [PMID: 25626905] (Mouse)		Mouse
Macho-Fernandez E, Koroleva E, Spencer C, Tighe M, Torrado E, Cooper A, Fu Y, Tumanov A Lymphotoxin beta receptor signaling limits mucosal damage through driving IL-23 production by epithelial cells. Mucosal Immunol, 2014-09-03;8(2):403-13. 2014-09-03 [PMID: 25183367] (Mouse)		Mouse
McCarthy M, Zhu L, Procario M, Weinberg J IL-17 contributes to neutrophil recruitment but not to control of viral replication during acute mouse adenovirus type 1 respiratory infection. Virology, 2014-04-19;456(0):259-67. 2014-04-19 [PMID: 24889245] (Mouse)		Mouse
Murphy A, O'Keeffe K, Lalor S, Maher B, Mills K, McLoughlin R Staphylococcus aureus infection of mice expands a population of memory gammadelta T cells that are protective against subsequent infection. J Immunol, 2014-03-12;192(8):3697-708. 2014-03-12 [PMID: 24623128] (Mouse)		Mouse
Selvanantham T, Escalante N, Cruz Tleugabulova M, Fieve S, Girardin S, Philpott D, Mallevaey T Nod1 and Nod2 enhance TLR-mediated invariant NKT cell activation during bacterial infection. J Immunol, 2013-10-25;191(11):5646-54. 2013-10-25 [PMID: 24163408] (Mouse)		Mouse
Kohler T, Reizis B, Johnson RS, Weighardt H, Forster I Influence of hypoxia-inducible factor 1-alpha on dendritic cell differentiation and migration. Eur. J. Immunol., 2012-05-01;42(5):1226-36. 2012-05-01 [PMID: 22539295] (Mouse)		Mouse
Veliz Rodriguez T, Moalli F, Polentarutti N, Paroni M, Bonavita E, Anselmo A, Nebuloni M, Mantero S, Jaillon S, Bragonzi A, Mantovani A, Riva F, Garlanda C Role of Toll interleukin-1 receptor (IL-1R) 8, a negative regulator of IL-1R/Toll-like receptor signaling, in resistance to acute Pseudomonas aeruginosa lung infection. Infect. Immun., 2011-10-24;80(1):100-9. 2011-10-24 [PMID: 22025515] (Mouse)		Mouse
El-Behi M, Ciric B, Dai H The encephalitogenicity of T(H)17 cells is dependent on IL-1- and IL-23-induced production of the cytokine GM-CSF. Nat. Immunol., 2011-04-24;12(6):568-75. 2011-04-24 [PMID: 21516111] (Mouse)		Mouse
Zhang X, Schmudde I, Laumonnier Y, Pandey MK, Clark JR, Konig P, Gerard NP, Gerard C, Wills-Karp M, Kohl J A critical role for C5L2 in the pathogenesis of experimental allergic asthma. J. Immunol., 2010-10-25;185(11):6741-52. 2010-10-25 [PMID: 20974988] (Mouse)		Mouse
Burton OT, Gibbs S, Miller N, Jones FM, Wen L, Dunne DW, Cooke A, Zaccone P Importance of TLR2 in the direct response of T lymphocytes to Schistosoma mansoni antigens. Eur. J. Immunol., 2010-08-01;40(8):2221-9. 2010-08-01 [PMID: 20480503] (Mouse)		Mouse
Show All 26 Publications. Collapse Publications.

Array DY1887

• IL-23A/IL-23 P19 Antibodies
• IL-23A/IL-23 P19 Lysate
• IL-23A/IL-23 P19 Proteins
• IL-23A/IL-23 P19 ELISAs
• IL-23A/IL-23 P19 Proteins and Enzymes