Mouse IL-11 DuoSet ELISA, 15 Plate

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Interleukin-11, also known as AGIF, is a pleiotropic cytokine in the IL-6 family, which also includes LIF, CNTF, Oncostatin M, Cardiotrophin-1, IL-27, and IL-31. It is secreted by osteoblasts, synoviocytes, fibroblasts, chondrocytes, intestinal myofibroblasts, and trophoblasts. It is found in the plasma mainly during inflammation, and is considered to be primarily anti-inflammatory. It stimulates hematopoiesis and thrombopoiesis, regulates macrophage differentiation, and confers mucosal protection in the intestine. It has also been found to enhance T cell polarization toward Th2, promote B cell IgG production, increase osteoclast bone absorption, protect endothelial cells from oxidative stress, and regulate epithelial proliferation and apoptosis. IL-11 signals through a receptor complex that contains IL-11 R alpha and gp130. A soluble form of IL-11 R alpha can bind IL-11 and either form a signaling complex with gp130 on the cell surface or inhibit cell surface IL-11 R alpha/gp130 signaling.

We have publications tested in 2 confirmed species: Human, Mouse.

Showing Publications 1 - 10 of 11. Show All 11 Publications. Collapse Publications.

Publications using DY418	Applications	Species
Singh, A;Cho, WJ;Pulimamidi, VK;Mittal, SK;Chauhan, SK; Interleukin-11 Suppresses Ocular Surface Inflammation and Accelerates Wound Healing Investigative ophthalmology & visual science 2023-11-01 [PMID: 37910094] (Human)		Human
J Dong, WW Lim, SG Shekeran, J Tan, SY Lim, JWT Goh, BL George, S Schafer, SA Cook, AA Widjaja Hepatocyte Specific gp130 Signalling Underlies APAP Induced Liver Injury International Journal of Molecular Sciences, 2022-06-25;23(13):. 2022-06-25 [PMID: 35806094] (Mouse)		Mouse
J Dong, S Viswanatha, E Adami, BK Singh, SP Chothani, B Ng, WW Lim, J Zhou, M Tripathi, NSJ Ko, SG Shekeran, J Tan, SY Lim, M Wang, PM Lio, PM Yen, S Schafer, SA Cook, AA Widjaja Hepatocyte-specific IL11 cis-signaling drives lipotoxicity and underlies the transition from NAFLD to NASH Nature Communications, 2021-01-04;12(1):66. 2021-01-04 [PMID: 33397952] (Mouse)		Mouse
T Kondratiev, M Shleeva, M Kapina, E Rubakova, I Linge, A Dyatlov, E Kondratiev, A Kaprelyant, A Apt Prolonged infection triggered by dormant Mycobacterium tuberculosis: Immune and inflammatory responses in lungs of genetically susceptible and resistant mice PLoS ONE, 2020-09-24;15(9):e0239668. 2020-09-24 [PMID: 32970762] (Mouse)		Mouse
CL Sanchez, SG Sims, JD Nowery, GP Meares Endoplasmic reticulum stress differentially modulates the IL-6 family of cytokines in murine astrocytes and macrophages Sci Rep, 2019-10-17;9(1):14931. 2019-10-17 [PMID: 31624329] (Mouse)		Mouse
X Zhang, N Kiapour, S Kapoor, T Khan, M Thamilaras, Y Tao, S Cohen, R Miller, RA Sobel, S Markovic-P IL-11 Induces Encephalitogenic Th17 Cells in Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis J. Immunol., 2019-07-24;0(0):. 2019-07-24 [PMID: 31341075] (Mouse)		Mouse
N Sanadgol, F Golab, Z Tashakkor, N Taki, S Moradi Kou, A Mostafaie, M Mehdizadeh, M Abdollahi, G Taghizadeh, M Sharifzade Neuroprotective effects of ellagic acid on cuprizone-induced acute demyelination through limitation of microgliosis, adjustment of CXCL12/IL-17/IL-11 axis and restriction of mature oligodendrocytes apoptosis Pharm Biol, 2017-12-01;55(1):1679-1687. 2017-12-01 [PMID: 28447514] (Mouse)		Mouse
Hiroyasu Nakano Critical contribution of nuclear factor erythroid 2-related factor 2 (NRF2) to electrophile-induced Interleukin-11 production J. Biol. Chem., 2016-11-21;0(0):. 2016-11-21 [PMID: 27872193] (Mouse)		Mouse
Figueiredo C, Drohomyrecky P, McCarthy S, Leontyev D, Ma X, Branch D, Dunn S Optimal attenuation of experimental autoimmune encephalomyelitis by intravenous immunoglobulin requires an intact interleukin-11 receptor. PLoS ONE, 2014-07-31;9(7):e101947. 2014-07-31 [PMID: 25078447] (Mouse)		Mouse
Cho N, Nguyen DH, Satkunendrarajah K, Branch DR, Fehlings MG Evaluating the role of IL-11, a novel cytokine in the IL-6 family, in a mouse model of spinal cord injury. J Neuroinflammation, 2012-06-20;9(1):134. 2012-06-20 [PMID: 22715999] (Mouse)		Mouse
Chalaris A, Adam N, Sina C, Rosenstiel P, Lehmann-Koch J, Schirmacher P, Hartmann D, Cichy J, Gavrilova O, Schreiber S, Jostock T, Matthews V, Hasler R, Becker C, Neurath MF, Reiss K, Saftig P, Scheller J, Rose-John S Critical role of the disintegrin metalloprotease ADAM17 for intestinal inflammation and regeneration in mice. J. Exp. Med., 2010-07-05;207(8):1617-24. 2010-07-05 [PMID: 20603312] (Mouse)		Mouse
Show All 11 Publications. Collapse Publications.

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