MMP-14/MT1-MMP Antibody (3-F7)

The matrix metalloproteinase (MMP) family (approximately 25 members in mammals) has been implicated in extracellular matrix remodeling associated with embryonic development, cancer formation and progression, and various other physiological and pathological events. MMP-14 is a membrane-bound matrix metalloproteinase (MT-MMP) capable of mediating pericellular proteolysis of extracellular matrix components. MMP-14 is therefore thought to be an important molecular tool for cellular remodeling of the surrounding matrix (1). Gelatinase A (type-IV collagenase; M(r) 72,000) is produced by tumour stroma cells and is believed to be crucial for their invasion and metastasis, acting by degrading extracellular matrix macro-molecules such as type IV collagen. MMP-14 may thus trigger invasion by tumor cells by activating pro-gelatinase A on the tumor cell surface (2). Observations identify MT1-MMP as a tumor-derived growth factor that regulates proliferation by controlling cell geometry within the confines of the 3D extracellular matrix (ECM) (3).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Showing Publications 1 - 2 of 2.

Publications using NBP2-67415	Applications	Species
Danilo Pellin, Natalie Claudio, Zihan Guo, Tahereh Ziglari, Ferdinando Pucci Gene Expression Profiling of Lymph Node Sub-Capsular Sinus Macrophages in Cancer Frontiers in Immunology 2021-06-08 [PMID: 34168645]
Feng Y, Cai H, Huang X et al. Active MT1-MMP is tethered to collagen fibers in DDR2-containing remnants Gene 2021-04-18 [PMID: 33882324]

Images	Ratings	Applications	Species	Date	Details
	4 reviewed by: Shinford Sun	WB	Human	09/16/2024	View Summary Application Western Blot Sample Tested Endothelial Species Human Lot H661919013
	5 reviewed by: Verified Customer	IHC-P	Human	10/17/2021	View Summary Application Immunohistochemistry-Paraffin Sample Tested Endometrial adenocarcinoma Species Human Lot 3-F7 Comments Comments Fixed paraffin-embedded sections. Tissue sections were deparaffinized. EDTA was used for antigen retrieval. Incubated for 10 hours with primary antibody.

Array NBP2-67415

• MMP-14/MT1-MMP Antibodies
• MMP-14/MT1-MMP ELISA Kits
• MMP-14/MT1-MMP Lysate
• MMP-14/MT1-MMP Proteins
• MMP-14/MT1-MMP ELISA
• MMP-14/MT1-MMP Proteins and Enzymes