Home » MMP-14/MT1-MMP » MMP-14/MT1-MMP Antibodies » MMP-14/MT1-MMP Antibody (128527) [Allophycocyanin]
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MMP-14/MT1-MMP Antibody (128527) [Allophycocyanin]

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MDA-MB-231 human breast cancer cell line was stained with Mouse Anti-Human MMP-14/MT1-MMP APC-conjugated Monoclonal Antibody (Catalog # FAB9181A, filled histogram) or isotype control antibody (Catalog # IC0041A, open histogram). View our protocol for Staining Membrane-associated Proteins.
MDA-MB-231 human breast cancer cell line was stained with Mouse Anti-Human MMP-14/MT1-MMP APC-conjugated Monoclonal Antibody (Catalog # FAB9181A, filled histogram) or isotype control antibody (Catalog # IC0041A, open ...read more

Product Details

Summary
Reactivity HuSpecies Glossary
Applications Flow
Clone
128527
Clonality
Monoclonal
Host
Mouse
Conjugate
Allophycocyanin

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
FAB9181U-100UG
Alexa Fluor 405
FAB9181V-100UG
Alexa Fluor 488
FAB9181G
Alexa Fluor 532
FAB9181X
Alexa Fluor 594
FAB9181T-100UG
Alexa Fluor 647
FAB9181R-100UG
Alexa Fluor 700
FAB9181N-100UG
Alexa Fluor 750
FAB9181S-100UG
Allophycocyanin/Cy7
FAB9181APCCY7
Biotin
FAB9181B
CoraFluor 1
FAB9181CL1
DyLight 350
FAB9181D
DyLight 405
FAB9181E
DyLight 488
FAB9181K
DyLight 550
FAB9181L
DyLight 594
FAB9181M
DyLight 650
FAB9181W
DyLight 680
FAB9181Y
DyLight 755
FAB9181Z
FITC
FAB9181F
HRP
FAB9181H
Janelia Fluor 525
FAB9181JF525
Janelia Fluor 549
FAB9181I
Janelia Fluor 585
FAB9181JF585
Janelia Fluor 635
FAB9181JF635
Janelia Fluor 646
FAB9181J
Janelia Fluor 669
FAB9181JF669
PE/Atto594
FAB9181PEATT594
PE/Cy5.5
FAB9181PECY55
PE/Cy7
FAB9181PECY7
Phycoerythrin
FAB9181P
Unconjugated
MAB9181-100
mFluor Violet 450 SE
FAB9181MFV450
mFluor Violet 500 SE
FAB9181MFV500
mFluor Violet 610 SE
FAB9181MFV610
View Available Formulations
Catalog# & Formulation Size Price
Standard Formulation
MAB9181-100
Carrier Free
FAB9181G
Carrier Free
FAB9181P
Carrier Free
MAB9181-SP
Carrier Free
MAB9181-500
Carrier Free
MAB9181-100
Carrier Free
FAB9181V-100UG
Carrier Free
FAB9181U-100UG
Carrier Free
FAB9181T-100UG
Carrier Free
FAB9181S-100UG
Carrier Free
FAB9181R-100UG
Carrier Free
FAB9181N-100UG
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MMP-14/MT1-MMP Antibody (128527) [Allophycocyanin] Summary

Immunogen
Mouse myeloma cell line NS0-derived recombinant human MMP‑14/MT1‑MMP
Tyr112-Ala541 (predicted)
Accession # P50281
Specificity
Detects human MMP‑14/MT1‑MMP in direct ELISAs and Western blots. Does not detect E. coli-expressed recombinant human MMP-14 catalytic domain (aa 112-284).
Source
N/A
Isotype
IgG2b
Clonality
Monoclonal
Host
Mouse
Gene
MMP14
Purity Statement
Protein A or G purified from hybridoma culture supernatant
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.
Learn about the Innovator's Reward

Applications/Dilutions

Dilutions
  • Flow Cytometry 10 uL/10^6 cells
Publications
Read Publication using FAB9181A.

Packaging, Storage & Formulations

Storage
Protect from light. Do not freeze.
  • 12 months from date of receipt, 2 to 8 °C as supplied.
Buffer
Supplied in a saline solution containing BSA and Sodium Azide.
Preservative
Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for MMP-14/MT1-MMP Antibody (128527) [Allophycocyanin]

  • EC 3.4.24
  • EC 3.4.24.80
  • matrix metallopeptidase 14 (membrane-inserted)
  • matrix metalloproteinase 14 (membrane-inserted)
  • matrix metalloproteinase-14
  • membrane type 1 metalloprotease
  • Membrane-type matrix metalloproteinase 1
  • Membrane-type-1 matrix metalloproteinase
  • MMP14
  • MMP-14
  • MMP-X1
  • MT1MMP
  • MT1-MMP
  • MT1-MMPMTMMP1
  • MT-MMP 1
  • MT-MMP1

Background

As the first member of membrane type (MT) MMPs, MMP-14, also known as MT1-MMP, plays an important role in extracellular matrix (ECM) remodeling by being able to degrade type I collagen, activate pro-MMP-2 and process cell adhesion molecules such as CD44 and integrin alpha V (1). MMP-14 is therefore a key enzyme in many physiological and pathological processes such as angiogenesis and tumor invasion. Structurally, MMP-14 consists of the following domains: a pro domain containing the furin cleavage site, a catalytic domain containing the zinc-binding site, a hinge region, a hemopexin-like domain, a transmembrane domain, and a cytoplasmic tail (2).

  1. Seike, M. (2003) Cancer Lett. 194:1.
  2. Sato, H. et al. (1994) Nature 370:61.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for MMP-14/MT1-MMP Antibody (FAB9181A)(1)


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Secondary Antibodies

 

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mFluor Violet Conjugated Antibodies

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Bioinformatics

Gene Symbol MMP14
Uniprot