MMP-13 Antibody (VIIIA2)

Collagenase 3 (MMP13) is a secreted 452 residue protein which is released from cells as aninactive zymogen and activated extracellularly by removal of its propeptide. MMP13 was first identified in tumor cells but has since been found in synoviocytes and normal fibroblasts stimulated by IL6 or a combination of TNF alpha and IL1. Under normal conditions, MMP13 is expressed during embryogenesis (fetal bone development) and is present only at very low levels in adult tissue. However, this enzyme is reported to be involved in the development and metastasis of breast and lung carcinomas, chondrosarcomas and osteosarcomas, head and neck carcinomas and some forms of skin cancer. Additionally, this enzyme plays an important role in degenerative bone diseases including osteoarthritis and rheumatoid arthritis. In rodents, MMP13 is thought to fill the role of MMP1, which they appear to lack.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 4 applications: Block/Neutralize, IF/IHC, IHC, Immunohistochemistry.

Showing Publications 1 - 3 of 3.

Publications using NB110-5919	Applications	Species
Liu J, Xu Y, Huang Y et al. Collagen membrane loaded with doxycycline through hydroxypropyl chitosan microspheres for the early reconstruction of alkali-burned cornea International journal of biological macromolecules 2023-06-01 [PMID: 37270120] (IHC)	IHC
Katta M, Cump?t? CN, ?uculin? MJ et al. Clinical, histopathological and immunohistochemical changes of the superficial marginal periodontium caused by orthodontic treatment with fixed metallic orthodontic appliances Romanian Journal of Morphology and Embryology 2022-11-15 [PMID: 36374148] (Immunohistochemistry, Block/Neutralize)	Immunohistochemistry, Block/Neutralize
Berceanu C, Mehedintu C, Berceanu S et al. Morphological and ultrasound findings in multiple pregnancy placentation. Rom J Morphol Embryol 2018-09-03 [PMID: 30173248] (IF/IHC, Human)	IF/IHC	Human

Array NB110-5919

• MMP-13 Antibodies
• MMP-13 ELISA Kits
• MMP-13 Lysate
• MMP-13 Proteins and Enzymes
• MMP-13 ELISAs