MDL-1/CLEC5A Antibody (283834) [Phycoerythrin] Summary
Immunogen |
Mouse myeloma cell line NS0-derived recombinant human MDL‑1/CLEC5A Tyr26-Lys188 Accession # Q9NY25 |
Specificity |
Detects human MDL‑1/CLEC5A in Western blots. Does not cross-react with recombinant mouse MDL‑1. |
Source |
N/A |
Isotype |
IgG2b |
Clonality |
Monoclonal |
Host |
Mouse |
Gene |
CLEC5A |
Purity Statement |
Protein A or G purified from hybridoma culture supernatant |
Innovator's Reward |
Test in a species/application not listed above to receive a full credit towards a future purchase. |
Packaging, Storage & Formulations
Storage |
Store the unopened product at 2 - 8° C. Do not use past expiration date. Protect from light. |
Buffer |
Supplied in a saline solution containing BSA and Sodium Azide. |
Preservative |
Sodium Azide |
Notes
This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.
Background
MDL-1 is an
approximately 40 kDa transmembrane glycoprotein belonging to the C-type lectin
superfamily. MDL-1 is expressed on immature myeloid cells, monocytes,
macrophages, dendritic cells, neutrophils, NK cells, and osteocytes. It
contains a charged lysine in the transmembrane region that enables it to
associate with DAP12 and deliver an activating signal. MDL-1 mediates inflammatory responses during
autoimmune arthritis and upon binding to Dengue and Japanese encephalitis viruses.
The extracellular domain (ECD) of MDL-1 contains a juxtamembrane stalk region
and one C-type lectin domain. Within the ECD, human and mouse MDL-1 share 67%
amino acid sequence identity.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are
guaranteed for 1 year from date of receipt.
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