Leptin/OB Antibody

Leptin, the obese (ob) gene product, is a small protein expressed in and secreted from adipose tissue of normal rodents. Studies suggest leptin acts as a circulating hormone capable of regulating body-weight homeostasis and energy balance. One possible target tissue for leptin is the hypothalamus, a proposed control center for satiety and energy expenditure. Ob gene knockout mice are characterized by several metabolic abnormalities including hyperglucocorticoidemia, hyperinsulinemia and insulin resistance, hyperglycemia, altered central nervous system activity, reduced metabolic rate of brown adipose tissue, and a large increase in white adipose tissue. Studies show that the administration of recombinant leptin to ob knockout mice reduces food intake and increases energy expenditure.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publication using NB300-611	Applications	Species
Kuramoto K, Kim YJ, Hong JH, He C The autophagy protein Becn1 improves insulin sensitivity by promoting adiponectin secretion via exocyst binding Cell reports 2021-05-25 [PMID: 34038729]

Array NB300-611

• Leptin/OB Antibodies
• Leptin/OB Antibody Pair
• Leptin/OB ELISA Kit
• Leptin/OB Lysate
• Leptin/OB Protein
• Leptin/OB ELISAs
• Leptin/OB Proteins and Enzymes