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Laforin/EPM2A Antibody (6C6)

 (10 Publications)
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Western Blot: Laforin/EPM2A Antibody (6C6) [H00007957-M02] - EPM2A monoclonal antibody (M02), clone 6C6 Analysis of EPM2A expression in PC-12.
Western Blot: Laforin/EPM2A Antibody (6C6) [H00007957-M02] - EPM2A monoclonal antibody (M02), clone 6C6 Analysis of EPM2A expression in PC-12.
Western Blot: Laforin/EPM2A Antibody (6C6) [H00007957-M02] - Analysis of EPM2A expression in transfected 293T cell line by EPM2A monoclonal antibody (M02), clone 6C6.Lane 1: EPM2A transfected lysate(37.2 KDa).Lane 2: ...read more
Sandwich ELISA: Laforin/EPM2A Antibody (6C6) [H00007957-M02] - Detection limit for recombinant GST tagged EPM2A is approximately 1ng/ml as a capture antibody.

Product Details

Summary
Reactivity Hu, Mu, RtSpecies Glossary
Applications WB, ELISA, IP
Clone
6C6
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated

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Laforin/EPM2A Antibody (6C6) Summary

Description
Quality control test: Antibody Reactive Against Recombinant Protein.
Immunogen
EPM2A (NP_001018051, 101 a.a. ~ 199 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. GNGPHHDRCCTYNENNLVDGVYCLPIGHWIEATGHTNEMKHTTDFYFNIAGHQAMHYSRILPNIWLGSCPRQVEHVTIKLKHELGITAVMNFQTEWDIV
Specificity
EPM2A - epilepsy, progressive myoclonus type 2A, Lafora disease (laforin)
Isotype
IgG2a Kappa
Clonality
Monoclonal
Host
Mouse
Gene
EPM2A
Purity
IgG purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.
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Applications/Dilutions

Dilutions
  • ELISA
  • Immunoprecipitation
  • Sandwich ELISA
  • Western Blot
Application Notes
Antibody reactivity against cell lysate and recombinant protein for WB. It has also been used for ELISA.
Publications
Read Publications using H00007957-M02.

Packaging, Storage & Formulations

Storage
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Buffer
In 1x PBS, pH 7.4
Preservative
No Preservative
Purity
IgG purified

Notes

This product is produced by and distributed for Abnova, a company based in Taiwan.

Alternate Names for Laforin/EPM2A Antibody (6C6)

  • EC 3.1.3.16
  • EC 3.1.3.48
  • epilepsy, progressive myoclonus type 2, Lafora disease (laforin)
  • epilepsy, progressive myoclonus type 2A, Lafora disease (laforin)
  • EPM2
  • EPM2A
  • Lafora PTPase
  • Laforin
  • LAFPTPase
  • LD
  • LDE
  • MELF

Background

This gene encodes a dual-specificity phosphatase that associates with polyribosomes. The encoded protein may be involved in the regulation of glycogen metabolism. Mutations in this gene have been associated with myoclonic epilepsy of Lafora. Alternative splicing results in multiple transcript variants.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for Laforin/EPM2A Antibody (H00007957-M02)(10)

We have publications tested in 1 confirmed species: Mouse.


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Showing Publications 1 - 10 of 10.
Publications using H00007957-M02 Applications Species
Sharmistha M, Baozhi C, Peixiang W et al. Lafora progressive myoclonus-epilepsy: Laforin targets malin to glycogen. Dis Model Mech. 2023-01-06 [PMID: 36511140]
Liu Q, Li J, Zhang W Et al. Glycogen accumulation and phase separation drives liver tumor initiation Cell 2021-10-28 [PMID: 34678143] (Mouse) Mouse
Irimia JM, Tagliabracci VS, Meyer CM et al. Muscle glycogen remodeling and glycogen phosphate metabolism following exhaustive exercise of wild type and laforin knockout mice. J Biol Chem 2015-07-27 [PMID: 26216881]
Zhu Y, Zhang M, Kelly AR, Cheng A. The carbohydrate-binding domain of overexpressed STBD1 is important for its stability and protein-protein interactions. Biosci Rep. 2014-05-18 [PMID: 24837458]
Sherwood AR, Johnson MB, Delgado-Escueta AV, Gentry MS. A Bioassay for Lafora Disease and Laforin Glucan Phosphatase Activity. Clin Biochem. 2013-09-06 [PMID: 24012855]
Turnbull J, Girard JM, Lohi H et al. Early-onset Lafora body disease. Brain. 2012-09-01 [PMID: 22961547]
Tiberia E, Turnbull J, Wang T et al. Increased Laforin and Laforin Binding to Glycogen Underlie Lafora Body Formation in Malin-deficient Lafora Disease. J Biol Chem. 2012-06-05 [PMID: 22669944]
Depaoli-Roach AA, Segvich DM, Meyer CM et al. LAFORIN AND MALIN KNOCKOUT MICE HAVE NORMAL GLUCOSE DISPOSAL AND INSULIN SENSITIVITY. Hum Mol Genet. 2012-01-04 [PMID: 22186021]
Turnbull J, Wang P, Girard JM et al. Glycogen hyperphosphorylation underlies lafora body formation. Ann Neurol. 2010-10-28 [PMID: 21077101]
Tagliabracci VS, Turnbull J, Wang W et al. Laforin is a glycogen phosphatase, deficiency of which leads to elevated phosphorylation of glycogen in vivo. Proc Natl Acad Sci U S A. 2007-11-26 [PMID: 18040046]

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Bioinformatics

Gene Symbol EPM2A
Entrez
OMIM
Uniprot