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IL-31RA Antibody (nemolizumab) - Humanized, IgG2SA

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IL-31RA Antibody (nemolizumab) - Humanized, IgG2SA P-STAT3 Assay was evaluated using Du145. The IC50 was approximately 0.1068 ug/ml.
IL-31RA Antibody (nemolizumab) - Humanized, IgG2SA P-STAT3 Assay was evaluated using Du145. The IC50 was approximately 0.1068 ug/ml.
IL-31RA Antibody (nemolizumab) - Humanized, IgG2SA Activation inhibition was evaluated using Hacat. The max induction fold was approximately 1.86.
Immobilized human IL31R His at 2 ug/mL can bind IL-31RA Antibody (nemolizumab) - Humanized, IgG2SA, EC50=0.0153 ug/mL.
Human IL31R HEK293 cells were stained with IL-31RA Antibody (nemolizumab) - Humanized, IgG2SA and negative control protein respectively, washed and then followed by PE and analyzed with FACS, EC50=0.307 ug/mL.

Product Details

Summary
Reactivity HuSpecies Glossary
Applications ELISA, Flow, Func
Clone
nemolizumab
Clonality
Monoclonal
Host
Human
Conjugate
Unconjugated
Concentration
LYOPH

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IL-31RA Antibody (nemolizumab) - Humanized, IgG2SA Summary

Description
Expressed from CHO. The heavy chain type is huIgG2, and the light chain type is hukappa. It has a predicted MW of 145.5 kDa.

Also known as 'nemolizumab'.

IgG2SA is human IgG2 with S378A mutation.

Upon receipt, store immediately at -20C or lower for 24 months in a lyophilized state. - 80C for 3 months after reconstitution. Avoid repeated freeze-thaw cycles.
Additional Information
Recombinant Monoclonal Antibody
Immunogen
IL-31Ra
Isotype
IgG2
Clonality
Monoclonal
Host
Human
Gene
IL31RA
Purity
Protein A purified
Endotoxin Note
< 0.001EU/ug,determined by LAL method.
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Applications/Dilutions

Dilutions
  • ELISA
  • Flow Cytometry
  • Functional

Reactivity Notes

Predicted species reactivity: Cynomolgus

Packaging, Storage & Formulations

Storage
Store at -20C in powder form. Store at -80C once reconstituted.
Buffer
Lyophilized from 25mM histidine, 8% sucrose, 0.01% Tween80 (pH6.2)
Preservative
No Preservative
Concentration
LYOPH
Purity
Protein A purified
Reconstitution Instructions
Reconstitute with sterile, distilled water to a final concentration of 1 mg/ml. Gently shake to solubilize completely. Do not vortex.

Alternate Names for IL-31RA Antibody (nemolizumab) - Humanized, IgG2SA

  • class I cytokine receptor
  • CRL3
  • CRL3Glmr
  • Cytokine receptor-like 3
  • GLMR
  • GLM-R
  • GLM-RMGC125346
  • GP130 like receptor
  • Gp130-like monocyte receptor
  • Gp130-like receptor
  • hGLM-R
  • IL-31 RA
  • IL-31 receptor subunit alpha
  • IL-31R subunit alpha
  • IL31RA
  • IL-31RA
  • IL-31RAGPLCRL
  • IL-31R-alpha
  • interleukin 31 receptor A
  • interleukin-31 receptor subunit alpha
  • PRO21384
  • soluble type I cytokine receptor CRL3
  • zcytoR17

Background

IL31RA is related to gp130 (IL6ST; MIM 600694), the common receptor subunit for IL6 (MIM 147620)-type cytokines. Oncostatin M receptor (OSMR; MIM 601743) and IL31RA form the heterodimeric receptor through which IL31 (MIM 609509) signals. Expression of IL31RA and OSMR mRNA is induced in activated monocytes, and both mRNAs are constitutively expressed in epithelial cells (Dillon et al., 2004 [PubMed 15184896]).[supplied by OMIM]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol IL31RA
Uniprot