IL-1 beta/IL-1F2 Antibody (B122) [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

IL-1 is a name that designates two pleiotropic cytokines, IL-1 alpha (IL-1F1) and IL-1 beta (IL-1F2, IL1B), which are the products of distinct genes. IL-1 alpha and IL-1 beta are structurally related polypeptides that share approximately 17% amino acid (aa) identity in mouse. Both proteins are produced by a wide variety of cells in response to inflammatory agents, infections, or microbial endotoxins. While IL-1 alpha and IL-1 beta are regulated independently, they bind to the same receptor and exert identical biological effects. IL-1 RI binds directly to IL-1 alpha or IL-1 beta and then associates with IL-1 R accessory protein (IL-1 R3/IL-1 R AcP) to form a high-affinity receptor complex that is competent for signal transduction. IL-1 RII has high affinity for IL-1 beta but functions as a decoy receptor and negative regulator of IL-1 beta activity. IL-1ra functions as a competitive antagonist by preventing IL-1 alpha and IL-1 beta from interacting with IL-1 RI. Intracellular cleavage of the IL-1 beta precursor by Caspase-1/ICE is a key step in the inflammatory response. The 17 kDa molecular weight mature mouse IL-1 beta shares 90% aa sequence identity with cotton rat and rat and 67%-78% with canine, equine, feline, human, porcine, and rhesus macaque IL-1 beta . IL-1 beta functions in a central role in immune and inflammatory responses, bone remodeling, fever, carbohydrate metabolism, and GH/IGF-I physiology. IL-1 beta dysregulation is implicated in many pathological conditions including sepsis, rheumatoid arthritis, inflammatory bowel disease, acute and chronic myelogenous leukemia, insulin-dependent diabetes mellitus, atherosclerosis, neuronal injury, and aging-related diseases.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Mouse, Rat.

We have publications tested in 5 applications: IHC, IHC-Fr, In Vivo, Neutralization, Western Blot.

Showing Publications 1 - 10 of 13. Show All 13 Publications. Collapse Publications.

Publications using MAB4012	Applications	Species
Han, X;Ning, Y;Dou, X;Wang, Y;Shan, Q;Shi, K;Wang, Z;Ding, C;Hao, M;Wang, K;Peng, M;Kuang, H;Yang, Q;Sang, X;Cao, G; Cornus officinalis with high pressure wine steaming enhanced anti-hepatic fibrosis: Possible through SIRT3-AMPK axis Journal of pharmaceutical analysis 2024-05-01 [PMID: 38646453] (Western Blot, Rat)	Western Blot	Rat
T Yoshida, NA Das, AJ Carpenter, R Izadpanah, SA Kumar, S Gautam, SB Bender, U Siebenlist, B Chandrasek Minocycline reverses IL-17A/TRAF3IP2-mediated p38 MAPK/NF-kappaB/iNOS/NO-dependent cardiomyocyte contractile depression and death Cell. Signal., 2020-06-15;73(0):109690. 2020-06-15 [PMID: 32553549] (Neutralization, Western Blot, Mouse)	Neutralization, Western Blot	Mouse
Mcknight Q, Jenkins S, Li X et Al. IL-1 beta drives production of FGF-23 at the onset of chronic kidney disease in mice J. Bone Miner. Res. 3/10/2020 [PMID: 32154933]
EE Hackett, H Charles-Me, SM O'Leary, LE Gleeson, N Muñoz-Wolf, S Case, A Wedderburn, DGW Johnston, MA Williams, A Smyth, M Ouimet, KJ Moore, EC Lavelle, SC Corr, SV Gordon, J Keane, FJ Sheedy Mycobacterium tuberculosis Limits Host Glycolysis and IL-1&beta by Restriction of PFK-M via MicroRNA-21 Cell Rep, 2020-01-07;30(1):124-136.e4. 2020-01-07 [PMID: 31914380] (Neutralization, Mouse)	Neutralization	Mouse
Hong‐Ming Zhou, Radomir M. Slominski, Leroy J. Seymour, Maria C. Bell, Priya Dave, Joseph Atumonye et al. Ex vivo culture of mouse skin activates an interleukin 1 alpha‐dependent inflammatory response Experimental Dermatology 1/1/2020 [PMID: 31566815]
Camilla Udjus, Fadila T. Cero, Bente Halvorsen, Dina Behmen, Cathrine R. Carlson, Bård A. Bendiksen et al. Caspase-1 induces smooth muscle cell growth in hypoxia-induced pulmonary hypertension American Journal of Physiology-Lung Cellular and Molecular Physiology 6/1/2019 [PMID: 30908936]
YY Kong, GQ Li, WJ Zhang, X Hua, CC Zhou, TY Xu, ZY Li, P Wang, CY Miao Nicotinamide phosphoribosyltransferase aggravates inflammation and promotes atherosclerosis in ApoE knockout mice Acta Pharmacol. Sin., 2019-03-04;0(0):. 2019-03-04 [PMID: 30833708] (IHC-Fr, Mouse)	IHC-Fr	Mouse
Li C, Zhang Y, Cheng X et al. PINK1 and PARK2 Suppress Pancreatic Tumorigenesis through Control of Mitochondrial Iron-Mediated Immunometabolism Dev. Cell 8/20/2018 [PMID: 30100261]
DJ Li, H Fu, J Tong, YH Li, LF Qu, P Wang, FM Shen Cholinergic anti-inflammatory pathway inhibits neointimal hyperplasia by suppressing inflammation and oxidative stress Redox Biol, 2017-11-16;15(0):22-33. 2017-11-16 [PMID: 29197233] (IHC, Mouse)	IHC	Mouse
MD Maler, PJ Nielsen, N Stichling, I Cohen, Z Ruzsics, C Wood, P Engelhard, M Suomalaine, I Gyory, M Huber, J Müller-Que, WWA Schamel, S Gordon, T Jakob, SF Martin, W Jahnen-Dec, UF Greber, MA Freudenber, G Fejer Key Role of the Scavenger Receptor MARCO in Mediating Adenovirus Infection and Subsequent Innate Responses of Macrophages MBio, 2017-08-01;8(4):. 2017-08-01 [PMID: 28765216] (Western Blot, Mouse)	Western Blot	Mouse
Botelho F, Nikota J, Bauer C, Morissette M, Iwakura Y, Kolbeck R, Finch D, Humbles A, Stampfli M Cigarette smoke-induced accumulation of lung dendritic cells is interleukin-1alpha-dependent in mice. Respir Res, 2012-09-19;13(0):81. 2012-09-19 [PMID: 22992200] (Neutralization, Mouse)	Neutralization	Mouse
Botelho F, Bauer C, Finch D, Nikota J, Zavitz C, Kelly A, Lambert K, Piper S, Foster M, Goldring J, Wedzicha J, Bassett J, Bramson J, Iwakura Y, Sleeman M, Kolbeck R, Coyle A, Humbles A, Stampfli M IL-1alpha/IL-1R1 expression in chronic obstructive pulmonary disease and mechanistic relevance to smoke-induced neutrophilia in mice. PLoS ONE, 2011-12-06;6(12):e28457. 2011-12-06 [PMID: 22163019] (In Vivo, Mouse)	In Vivo	Mouse
Rider P, Carmi Y, Guttman O, Braiman A, Cohen I, Voronov E, White MR, Dinarello CA, Apte RN IL-1alpha and IL-1beta recruit different myeloid cells and promote different stages of sterile inflammation. J. Immunol., 2011-09-19;187(9):4835-43. 2011-09-19 [PMID: 21930960] (Western Blot, Mouse)	Western Blot	Mouse
Show All 13 Publications. Collapse Publications.

Array MAB4012

• IL-1 beta/IL-1F2 Antibodies
• IL-1 beta/IL-1F2 ELISA Kits
• IL-1 beta/IL-1F2 Lysate
• IL-1 beta/IL-1F2 Proteins
• IL-1 beta/IL-1F2 ELISAs
• IL-1 beta/IL-1F2 Proteins and Enzymes