IL-1 beta/IL-1F2 Antibody (30311) [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

IL-1 is a name that designates two pleiotropic cytokines, IL-1 alpha (IL-1F1) and IL-1 beta (IL-1F2, IL1B), which are the products of distinct genes. IL-1 alpha and IL-1 beta are structurally related polypeptides that share approximately 17% amino acid (aa) identity in mouse. Both proteins are produced by a wide variety of cells in response to inflammatory agents, infections, or microbial endotoxins. While IL-1 alpha and IL-1 beta are regulated independently, they bind to the same receptor and exert identical biological effects. IL-1 RI binds directly to IL-1 alpha or IL-1 beta and then associates with IL-1 R accessory protein (IL-1 R3/IL-1 R AcP) to form a high-affinity receptor complex that is competent for signal transduction. IL-1 RII has high affinity for IL-1 beta but functions as a decoy receptor and negative regulator of IL-1 beta activity. IL-1ra functions as a competitive antagonist by preventing IL-1 alpha and IL-1 beta from interacting with IL-1 RI. Intracellular cleavage of the IL-1 beta precursor by Caspase-1/ICE is a key step in the inflammatory response. The 17 kDa molecular weight mature mouse IL-1 beta shares 90% aa sequence identity with cotton rat and rat and 67%-78% with canine, equine, feline, human, porcine, and rhesus macaque IL-1 beta . IL-1 beta functions in a central role in immune and inflammatory responses, bone remodeling, fever, carbohydrate metabolism, and GH/IGF-I physiology. IL-1 beta dysregulation is implicated in many pathological conditions including sepsis, rheumatoid arthritis, inflammatory bowel disease, acute and chronic myelogenous leukemia, insulin-dependent diabetes mellitus, atherosclerosis, neuronal injury, and aging-related diseases.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 9 applications: Bioassay, ELISA Capture, ELISA Development, ELISA Development (Capture), IHC-Fr, Immunoprecipitation, Luminex Development, Neutralization, Western Blot.

Showing Publications 1 - 10 of 54. Show All 54 Publications. Collapse Publications.

Publications using MAB401	Applications	Species
Rosli, S;Harpur, CM;Lam, M;West, AC;Hodges, C;Mansell, A;Lawlor, KE;Tate, MD; Gasdermin D promotes hyperinflammation and immunopathology during severe influenza A virus infection Cell death & disease 2023-11-09 [PMID: 37945599] (Western Blot, Mouse)	Western Blot	Mouse
Hiraga, H;Chinda, D;Maeda, T;Murai, Y;Ogasawara, K;Muramoto, R;Ota, S;Hasui, K;Sakuraba, H;Ishiguro, Y;Yoshida, S;Asano, K;Nakane, A;Fukuda, S; Vitamin A Promotes the Fusion of Autophagolysosomes and Prevents Excessive Inflammasome Activation in Dextran Sulfate Sodium-Induced Colitis International journal of molecular sciences 2023-05-12 [PMID: 37240022] (Western Blot, Mouse)	Western Blot	Mouse
Hongxu Xian, Kosuke Watari, Elsa Sanchez-Lopez, Joseph Offenberger, Janset Onyuru, Harini Sampath et al. FEN1-generated oxidized DNA fragments exit mitochondria via mPTP- and VDAC-dependent channels to activate NLRP3 inflammasome and interferon signaling Immunity 8/1/2022 [PMID: 35835107]
Y Hwang, HC Kim, EJ Shin Effect of rottlerin on astrocyte phenotype polarization after trimethyltin insult in the dentate gyrus of mice Journal of Neuroinflammation, 2022-06-11;19(1):142. 2022-06-11 [PMID: 35690821] (Western Blot, Mouse)	Western Blot	Mouse
Taida Huang, Xiaomin Huang, Hui Li, Junhua Qi, Nan Wang, Yi Xu et al. Maternal Cigarette Smoke Exposure Exaggerates the Behavioral Defects and Neuronal Loss Caused by Hypoxic-Ischemic Brain Injury in Female Offspring Frontiers in Cellular Neuroscience 2/18/2022 [PMID: 35250486]
Hongxu Xian, Yuan Liu, Alexandra Rundberg Nilsson, Raphaella Gatchalian, Timothy R. Crother, Warren G. Tourtellotte et al. Metformin inhibition of mitochondrial ATP and DNA synthesis abrogates NLRP3 inflammasome activation and pulmonary inflammation Immunity 7/1/2021 [PMID: 34115964]
Gayoung Kim, Kyeong-Hun Choi, Hangeun Kim, Dae-Kyun Chung Alleviation of LPS-Induced Inflammation and Septic Shock by Lactiplantibacillus plantarum K8 Lysates International Journal of Molecular Sciences 5/31/2021 [PMID: 34072918]
DC Shippy, C Wilhelm, PA Viharkumar, TJ Raife, TK Ulland &beta-Hydroxybutyrate inhibits inflammasome activation to attenuate Alzheimer's disease pathology Journal of Neuroinflammation, 2020-09-21;17(1):280. 2020-09-21 [PMID: 32958021] (ELISA Capture, Mouse)	ELISA Capture	Mouse
Charlie H.T. Kwok, Annastazia E Learoyd, Julia Canet-Pons, Tuan Trang, Maria Fitzgerald Spinal interleukin-6 contributes to central sensitisation and persistent pain hypersensitivity in a model of juvenile idiopathic arthritis Brain, Behavior, and Immunity 11/1/2020 [PMID: 32791212]
SY Cai, M Ge, A Mennone, R Hoque, X Ouyang, JL Boyer Inflammasome is activated in the liver of cholestatic patients and aggravates hepatic injury in bile duct ligated mouse Cell Mol Gastroenterol Hepatol, 2019-12-27;0(0):. 2019-12-27 [PMID: 31887435] (Bioassay, Human)	Bioassay	Human
DG Kim, JW Choi, IJ Jo, MJ Kim, HS Lee, SH Hong, HJ Song, GS Bae, SJ Park Berberine ameliorates lipopolysaccharide?induced inflammatory responses in mouse inner medullary collecting duct?3 cells by downregulation of NF?kappaB pathway Mol Med Rep, 2019-11-19;0(0):. 2019-11-19 [PMID: 31746359] (ELISA Development, Mouse)	ELISA Development	Mouse
Z Pang, R Raudonis, C McCormick, Z Cheng Early growth response 1 deficiency protects host against Pseudomonas aeruginosa lung infection Infect. Immun., 2019-12-17;0(0):. 2019-12-17 [PMID: 31611276] (ELISA Capture, Mouse)	ELISA Capture	Mouse
Dina B. AbuSamra, Jérôme Mauris, Pablo Argüeso Galectin-3 initiates epithelial-stromal paracrine signaling to shape the proteolytic microenvironment during corneal repair Science Signaling 7/18/2019 [PMID: 31311846]
OJ Sul, M Rajasekara, HJ Park, JH Suh, HS Choi MicroRNA-29b Enhances Osteoclast Survival by Targeting BCL-2-Modifying Factor after Lipopolysaccharide Stimulation Oxid Med Cell Longev, 2019-04-10;2019(0):6018180. 2019-04-10 [PMID: 31093317] (Western Blot, Mouse)	Western Blot	Mouse
A Polykratis, A Martens, RO Eren, Y Shirasaki, M Yamagishi, Y Yamaguchi, S Uemura, M Miura, B Holzmann, G Kollias, M Armaka, G van Loo, M Pasparakis A20 prevents inflammasome-dependent arthritis by inhibiting macrophage necroptosis through its ZnF7 ubiquitin-binding domain Nat. Cell Biol., 2019-05-13;0(0):. 2019-05-13 [PMID: 31086261] (Bioassay, Mouse)	Bioassay	Mouse
Elsa Sanchez-Lopez, Zhenyu Zhong, Alexandra Stubelius, Shannon R. Sweeney, Laela M. Booshehri, Laura Antonucci et al. Choline Uptake and Metabolism Modulate Macrophage IL-1 beta and IL-18 Production Cell Metabolism 6/1/2019 [PMID: 30982734]
R Kolb, P Kluz, ZW Tan, N Borcherdin, N Bormann, A Vishwakarm, L Balcziak, P Zhu, BS Davies, F Gourronc, LZ Liu, X Ge, BH Jiang, K Gibson-Cor, A Klingelhut, NS Tan, Y Zhu, FS Sutterwala, X Shen, W Zhang Obesity-associated inflammation promotes angiogenesis and breast cancer via angiopoietin-like 4 Oncogene, 2018-12-05;0(0):. 2018-12-05 [PMID: 30518876] (ELISA Development (Capture), Mouse)	ELISA Development (Capture)	Mouse
Z Zhong, S Liang, E Sanchez-Lo, F He, S Shalapour, XJ Lin, J Wong, S Ding, E Seki, B Schnabl, AL Hevener, HB Greenberg, T Kisseleva, M Karin New mitochondrial DNA synthesis enables NLRP3 inflammasome activation Nature, 2018-07-25;0(0):. 2018-07-25 [PMID: 30046112] (Mouse)		Mouse
Yina Chen, Qian Zhao, Yangjie Sun, Yin Jin, Jie Zhang, Jiansheng Wu Melatonin induces anti-inflammatory effects via endoplasmic reticulum stress in RAW264.7 macrophages Molecular Medicine Reports 2/15/2018 [PMID: 29484392]
AK Mehta, T Doherty, D Broide, M Croft TNF Family Member LIGHT Acts with IL-1? and TGF-? to Promote Airway Remodeling During Rhinovirus Infection Allergy, 2018-03-01;0(0):. 2018-03-01 [PMID: 29315623] (Neutralization, Mouse)	Neutralization	Mouse
NR Han, HY Kim, NR Kim, WK Lee, H Jeong, HM Kim, HJ Jeong Leucine and glycine dipeptides of porcine placenta ameliorate physical fatigue through enhancing dopaminergic systems Mol Med Rep, 2017-12-20;0(0):. 12/20/2017 [PMID: 29286166]
Z Pang, RD Junkins, AJ MacNeil, C McCormick, Z Cheng, WM Chen, TJ Lin The calcineurin-NFAT axis contributes to host defense during Pseudomonas aeruginosa lung infection J. Leukoc. Biol., 2017-10-10;0(0):. 2017-10-10 [PMID: 29018150] (ELISA Development (Capture), Mouse)	ELISA Development (Capture)	Mouse
Y Oh, YS Kwon, BD Jung Anti-inflammatory Effects of the Natural Compounds Cortex Phellodendri and Humulus japonicus on Pelvic Inflammatory Disease in Mice Int J Med Sci, 2017-07-18;14(8):729-734. 2017-07-18 [PMID: 28824307] (ELISA Development (Capture), Mouse)	ELISA Development (Capture)	Mouse
L Zhang, Z Tian, W Li, X Wang, Z Man, S Sun Inhibitory effect ofquercetinon titaniumparticle-inducedendoplasmic reticulum stress (ERS)-related apoptosisandin vivoosteolysis Biosci. Rep., 2017-07-31;0(0):. 2017-07-31 [PMID: 28760844] (ELISA Development (Capture), Mouse)	ELISA Development (Capture)	Mouse
SY Nam, KY Kim, MH Kim, JB Jang, SY Rah, HJ Chae, JM Lee, HM Kim, HJ Jeong Anti-inflammatory effects of a traditional Korean medicine: Ojayeonjonghwan Pharm Biol, 2017-12-01;55(1):1856-1862. 2017-12-01 [PMID: 28614972] (ELISA Development (Capture), Mouse)	ELISA Development (Capture)	Mouse
P Dhar, GZ Ng, EM Dunne, P Sutton Mucin 1 protects against severe Streptococcus pneumoniae infection Virulence, 2017-07-13;0(0):0. 2017-07-13 [PMID: 28605238] (ELISA Development (Capture), Mouse)	ELISA Development (Capture)	Mouse
C Dempsey Inhibiting the NLRP3 inflammasome with MCC950 promotes non-phlogistic clearance of amyloid-? and cognitive function in APP/PS1 mice Brain Behav. Immun, 2016-12-18;0(0):. 2016-12-18 [PMID: 28003153] (ELISA Development (Capture), Mouse)	ELISA Development (Capture)	Mouse
Yoonsook Kim Oryza sativa (Rice) Hull Extract Inhibits Lipopolysaccharide-Induced Inflammatory Response in RAW264.7 Macrophages by Suppressing Extracellular Signal-regulated Kinase, c-Jun N-terminal Kinase, and Nuclear Factor-?B Activation Pharmacogn Mag, 2016-10-01;12(48):295-301. 2016-10-01 [PMID: 27867272] (ELISA Development (Capture), Mouse)	ELISA Development (Capture)	Mouse
Tyler K. Ulland, Nidhi Jain, Emma E. Hornick, Eric I. Elliott, Gwendolyn M. Clay, Jeffrey J. Sadler et al. Nlrp12 mutation causes C57BL/6J strain-specific defect in neutrophil recruitment Nature Communications 10/25/2016 [PMID: 27779193]
Ali Kassem, Catharina Lindholm, Ulf H Lerner Toll-Like Receptor 2 Stimulation of Osteoblasts Mediates Staphylococcus Aureus Induced Bone Resorption and Osteoclastogenesis through Enhanced RANKL PLOS ONE 6/16/2016 [PMID: 27311019]
Kim L, Morita R, Kobayashi Y, Eisenbarth S, Lee C, Elias J, Eynon E, Flavell R AMCase is a crucial regulator of type 2 immune responses to inhaled house dust mites. Proc Natl Acad Sci U S A, 2015-05-18;112(22):E2891-9. 2015-05-18 [PMID: 26038565] (ELISA Development (Capture), Mouse)	ELISA Development (Capture)	Mouse
Lalani A, Moore C, Luo C, Kreider B, Liu Y, Morse H, Xie P Myeloid cell TRAF3 regulates immune responses and inhibits inflammation and tumor development in mice. J Immunol, 2014-11-24;194(1):334-48. 2014-11-24 [PMID: 25422508] (ELISA Development, Mouse)	ELISA Development	Mouse
Ingham V, Williams A, Bate C Glimepiride reduces CD14 expression and cytokine secretion from macrophages. J Neuroinflammation, 2014-06-21;11(0):115. 2014-06-21 [PMID: 24952384] (ELISA Development (Capture), Mouse)	ELISA Development (Capture)	Mouse
Bakker P, Butter L, Claessen N, Teske G, Sutterwala F, Florquin S, Leemans J A tissue-specific role for Nlrp3 in tubular epithelial repair after renal ischemia/reperfusion. Am J Pathol, 2014-05-11;184(7):2013-22. 2014-05-11 [PMID: 24823805] (Immunoprecipitation, Mouse)	Immunoprecipitation	Mouse
Benahmed F, Chyou S, Dasoveanu D, Chen J, Kumar V, Iwakura Y, Lu T Multiple CD11c+ cells collaboratively express IL-1beta to modulate stromal vascular endothelial growth factor and lymph node vascular-stromal growth. J Immunol, 2014-03-21;192(9):4153-63. 2014-03-21 [PMID: 24659690] (Neutralization, Mouse)	Neutralization	Mouse
Junkins R, MacNeil A, Wu Z, McCormick C, Lin T Regulator of calcineurin 1 suppresses inflammation during respiratory tract infections. J Immunol, 2013-04-15;190(10):5178-86. 2013-04-15 [PMID: 23589609] (ELISA Development (Capture), Mouse)	ELISA Development (Capture)	Mouse
Marlies Galle, Shouguang Jin, Pieter Bogaert, Mira Haegman, Peter Vandenabeele, Rudi Beyaert The Pseudomonas aeruginosa Type III Secretion System Has an Exotoxin S/T/Y Independent Pathogenic Role during Acute Lung Infection PLoS ONE 7/23/2012 [PMID: 22844497]
Eisenbarth , Stephani, Williams , Adam, Colegio , Oscar R, Meng , Hailong, Strowig , Till, Rongvaux , Anthony, Henao-Mejia , Jorge, Thaiss , Christop, Joly , Sophie, Gonzalez , David G, Xu , Lan, Zenewicz , Lauren A, Haberman , Ann M, Elinav , Eran, Kleinstein , Steven H, Sutterwala , Fayyaz S, Flavell , Richard NLRP10 is a NOD-like receptor essential to initiate adaptive immunity by dendritic cells. Nature, 2012-04-25;484(7395):510-3. 2012-04-25 [PMID: 22538615] (Mouse)		Mouse
Deepak Kumar Kaushik, Malvika Gupta, Kanhaiya Lal Kumawat, Anirban Basu NLRP3 Inflammasome: Key Mediator of Neuroinflammation in Murine Japanese Encephalitis PLoS ONE 2/29/2012 [PMID: 22393394]
Zhang M, Yin L, Zhang K, Sun W, Yang S, Zhang B, Salzman P, Wang W, Liu C, Vidyasagar S, Zhang L, Ju S, Okunieff P, Zhang L Response patterns of cytokines/chemokines in two murine strains after irradiation. Cytokine, 2012-01-25;58(2):169-77. 2012-01-25 [PMID: 22277799] (Luminex Development, Mouse)	Luminex Development	Mouse
Michael C. Schmid, Christie J. Avraamides, Philippe Foubert, Yuval Shaked, Sang Won Kang, Robert S. Kerbel et al. Combined Blockade of Integrin-alpha 4 beta 1 Plus Cytokines SDF-1 alpha or IL-1 beta Potently Inhibits Tumor Inflammation and Growth Cancer Research 11/15/2011 [PMID: 21948958]
Linglin Xie, M. Teresa Ortega, Silvia Mora, Stephen K. Chapes Interactive Changes between Macrophages and Adipocytes Clinical and Vaccine Immunology 4/1/2010 [PMID: 20164250]
Wu W, Mehta H, Chakrabarty K, Booth JL, Duggan ES, Patel KB, Ballard JD, Coggeshall KM, Metcalf JP Resistance of human alveolar macrophages to Bacillus anthracis lethal toxin. J. Immunol., 2009-10-07;183(9):5799-806. 2009-10-07 [PMID: 19812208] (ELISA Development, Mouse)	ELISA Development	Mouse
Scatizzi JC, Mavers M, Hutcheson J, Young B, Shi B, Pope RM, Ruderman EM, Samways DS, Corbett JA, Egan TM, Perlman H The CDK domain of p21 is a suppressor of IL-1beta-mediated inflammation in activated macrophages. Eur. J. Immunol., 2009-03-01;39(3):820-5. 2009-03-01 [PMID: 19189309] (Western Blot, Mouse)	Western Blot	Mouse
Maelfait J, Vercammen E, Janssens S, Schotte P, Haegman M, Magez S, Beyaert R Stimulation of Toll-like receptor 3 and 4 induces interleukin-1beta maturation by caspase-8. J. Exp. Med., 2008-08-25;205(9):1967-73. 2008-08-25 [PMID: 18725521] (Western Blot, Mouse)	Western Blot	Mouse
M. Galle, P. Schotte, M. Haegman, A. Wullaert, H. J. Yang, S. Jin et al. The Pseudomonas aeruginosa Type III secretion system plays a dual role in the regulation of caspase-1 mediated IL-1beta maturation Journal of Cellular and Molecular Medicine 9/1/2008 [PMID: 18081695]
Smith SE, Li J, Garbett K, Mirnics K, Patterson PH Maternal immune activation alters fetal brain development through interleukin-6. J. Neurosci., 2007-10-03;27(40):10695-702. 2007-10-03 [PMID: 17913903] (Neutralization, Mouse)	Neutralization	Mouse
Cunha TM, Verri WA, Jr, Fukada SY, Guerrero AT, Santodomingo-Garzon T, Poole S, Parada CA, Ferreira SH, Cunha FQ TNF-alpha and IL-1beta mediate inflammatory hypernociception in mice triggered by B1 but not B2 kinin receptor. Eur. J. Pharmacol., 2007-07-13;573(1):221-9. 2007-07-13 [PMID: 17669394] (ELISA Development, Mouse)	ELISA Development	Mouse
Penido C, Conte FP, Chagas MS, Rodrigues CA, Pereira JF, Henriques MG Antiinflammatory effects of natural tetranortriterpenoids isolated from Carapa guianensis Aublet on zymosan-induced arthritis in mice. Inflamm. Res., 2006-11-01;55(11):457-64. 2006-11-01 [PMID: 17122962] (ELISA Development, Mouse)	ELISA Development	Mouse
Osuchowski MF, Welch K, Siddiqui J, Remick DG Circulating cytokine/inhibitor profiles reshape the understanding of the SIRS/CARS continuum in sepsis and predict mortality. J. Immunol., 2006-08-01;177(3):1967-74. 2006-08-01 [PMID: 16849510] (ELISA Development, Mouse)	ELISA Development	Mouse
Dajee M, Muchamuel T, Schryver B, Oo A, Alleman-Sposeto J, De Vry CG, Prasad S, Ruhrmund D, Shyamsundar R, Mutnick D, Mai K, Le T, Parham C, Zhang J, Komuves L, Colby T, Hudak S, McEvoy LM, Ehrhardt RO Blockade of experimental atopic dermatitis via topical NF-kappaB decoy oligonucleotide. J. Invest. Dermatol., 2006-04-20;126(8):1792-803. 2006-04-20 [PMID: 16628194] (IHC-Fr, Mouse)	IHC-Fr	Mouse
Osuchowski MF, Siddiqui J, Copeland S, Remick DG Sequential ELISA to profile multiple cytokines from small volumes. J. Immunol. Methods, 2005-07-01;302(1):172-81. 2005-07-01 [PMID: 16023134] (ELISA Development, Mouse)	ELISA Development	Mouse
Ellaban E, Bolgos G, Remick D Selective macrophage suppression during sepsis. Cell. Immunol., 2005-02-26;231(1):103-11. 2005-02-26 [PMID: 15919375] (ELISA Development, Mouse)	ELISA Development	Mouse
Show All 54 Publications. Collapse Publications.

Array MAB401

• IL-1 beta/IL-1F2 Antibodies
• IL-1 beta/IL-1F2 ELISA Kits
• IL-1 beta/IL-1F2 Lysate
• IL-1 beta/IL-1F2 Proteins
• IL-1 beta/IL-1F2 ELISAs
• IL-1 beta/IL-1F2 Proteins and Enzymes