IGF-II R/IGF2R Antibody (MEM-238) - BSA Free

CD222 (CIMPR, cation-independent mannose 6-phosphate receptor; IGF2 receptor) is a ubiquitously expressed 250 kDa transmembrane protein. No more than 10% of CD222 is present on the cell surface where it serves as a multifunctional receptor. Intracellular (major) fraction of CD222 is involved in transport of newly synthesized lysosomal enzymes modified by mannose 6-phosphate from Golgi apparatus to lysosomes. The cell surface CD222 binds and internalizes exogeneous mannose 6-phosphate-containing ligands. Importantly, CD222 is crutial for internalization and degradation of insulin-like growth factor 2, thus controling cell growth. CD222 also complexes CD87 (urokinase-type plasminogen-activator receptor), plasminogen and latent TGF-beta, last but not least CD222 serves as a receptor for heparanase and even for Listeria.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Showing Publications 1 - 2 of 2.

Publications using NB500-464	Applications	Species
El-Shewy, H M, M-H Lee et al. The Insulin-like Growth Factor Type 1 Insulin-like Growth Factor Type 2/Mannose-6-phosphate Receptors Independently Regulate ERK1/2 Activity in HEK293 Cells. 282: 26150-26157. 2007-01-01 [PMID: 17620336]
Leksa V, Godar S, Cebecauer M et al. The N terminus of mannose 6-phosphate/insulin-like growth factor 2 receptor in regulation of fibrinolysis and cell migration J Biol Chem 2002-10-25 [PMID: 12189157] Details: This citation used the FITC version of this antibody.

Array NB500-464

• IGF-II R/IGF2R Antibodies
• IGF-II R/IGF2R Protein
• IGF-II R/IGF2R Proteins and Enzymes
• IGF-II R/IGF2R ELISA