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IFN-alpha/beta R1 Antibody Pair [HRP]

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Sandwich ELISA: IFN-alpha/beta R1 Antibody Pair [HRP] [NBP2-79589] - This standard curve is only for demonstration purposes. A standard curve should be generated for each assay.
Sandwich ELISA: IFN-alpha/beta R1 Antibody Pair [HRP] [NBP2-79589] - This standard curve is only for demonstration purposes. A standard curve should be generated for each assay.

Product Details

Summary
Reactivity MuSpecies Glossary
Applications ELISA
Conjugate
HRP
Standard Curve Range
125-8000 pg/ml (example only; lot dependent)
Sensitivity
125 pg/ml (example only; lot dependent)

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
HRP
NBP2-79589-5Plates
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IFN-alpha/beta R1 Antibody Pair [HRP] Summary

Description
Solid Phase sandwich ELISA for the quantitative determination of Mouse IFN-alpha/beta R1.
Specificity
This solid phase sandwich ELISA utilizes an antibody specific for Mouse IFN-alpha/beta R1.
Standard Curve Range
125-8000 pg/ml (example only; lot dependent)
Sensitivity
125 pg/ml (example only; lot dependent)
Assay Type
Sandwich ELISA
Sample Volume
100 ul
Gene
IFNAR1

Applications/Dilutions

Dilutions
  • ELISA
  • Sandwich ELISA

Packaging, Storage & Formulations

Storage
Storage of components varies. See protocol for specific instructions.

Kit Components

Components
  2. Rabbit Polyclonal Detection Antibody (HRP-conjugated)
  3. Standard

Alternate Names for IFN-alpha/beta R1 Antibody Pair [HRP]

  • alpha-type antiviral protein
  • AVP
  • beta-type antiviral protein
  • CRF2-1
  • Cytokine receptor class-II member 1
  • Cytokine receptor family 2 member 1
  • human interferon-alpha receptor (HuIFN-alpha-Rec)10IFRC
  • IFN-alpha/beta R1
  • IFN-alpha/beta receptor 1
  • IFN-alpha-REC
  • IFNAR
  • IFNAR1
  • IFN-aR1
  • IFNBR
  • IFNbR1
  • IFN-bR1
  • IFN-R-1
  • interferon (alpha, beta and omega) receptor 1
  • interferon alpha/beta receptor 1
  • interferon-alpha/beta receptor alpha chain
  • interferon-beta receptor 1
  • Type I interferon receptor 1

Background

Interferon alpha receptor 1 (IFN-alpha R1) is a class II cytokine receptor which belongs to type I human interferons (IFNs) family. IFNs plays a role in antiviral, antiproliferative, immunomodulatory, antitumor, and antiparasitic activities by inducing transcription of IFN-stimuated genes (ISGs) through activation of the Jak-STAT pathway. Specifically, IFN- R1 is a 135-kda signal transducing subunit of the IFN alpha/beta receptor complex (IFN-alpha R) (1). IFN-alpha R1 is phospholyated through PTK- and PKC-mediated phosphorylation, which initiates docking of STAT proteins to IFNs. This leads to activation of STAT proteins by PTK-mediated phosphorylation. The mechanism behind the amplification of IFN-alpha R complex mediated transmembrane signaling has been linked to tyrosine phosphorylation on IFN-alpha R1 (2).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Antibody Pairs are guaranteed for 6 months from date of receipt.

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Bioinformatics

Gene Symbol IFNAR1