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IFN-alpha/beta R1 Antibody (MM0336-8H64) [HRP]

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, Flow, CyTOF-ready
Clone
MM0336-8H64
Clonality
Monoclonal
Host
Mouse
Conjugate
HRP

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
NBP2-11731AF350
Alexa Fluor 405
NBP2-11731AF405
Alexa Fluor 488
NBP2-11731AF488
Alexa Fluor 532
NBP2-11731AF532
Alexa Fluor 594
NBP2-11731AF594
Alexa Fluor 647
NBP2-11731AF647
Alexa Fluor 700
NBP2-11731AF700
Alexa Fluor 750
NBP2-11731AF750
Allophycocyanin
NBP2-11731APC
Allophycocyanin/Cy7
NBP2-11731APCCY7
Biotin
NBP2-11731B
CoraFluor 1
NBP2-11731CL1
DyLight 350
NBP2-11731UV
DyLight 405
NBP2-11731V
DyLight 488
NBP2-11731G
DyLight 550
NBP2-11731R
DyLight 594
NBP2-11731DL594
DyLight 650
NBP2-11731C
DyLight 680
NBP2-11731FR
DyLight 755
NBP2-11731IR
FITC
NBP2-11731F
Janelia Fluor 525
NBP2-11731JF525
Janelia Fluor 549
NBP2-11731JF549
Janelia Fluor 585
NBP2-11731JF585
Janelia Fluor 635
NBP2-11731JF635
Janelia Fluor 646
NBP2-11731JF646
Janelia Fluor 669
NBP2-11731JF669
PE
NBP2-11731PE
PE/Atto594
NBP2-11731PEATT594
PE/Cy5.5
NBP2-11731PECY55
PE/Cy7
NBP2-11731PECY7
PerCP
NBP2-11731PCP
Unconjugated
NBP2-11731
mFluor Violet 450 SE
NBP2-11731MFV450
mFluor Violet 500 SE
NBP2-11731MFV500
mFluor Violet 610 SE
NBP2-11731MFV610
View Available Formulations
Catalog# & Formulation Size Price
Standard Formulation
NBP2-11731
Azide and BSA Free
NBP2-11731
Azide and BSA Free
NBP2-11731-0.025mg
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IFN-alpha/beta R1 Antibody (MM0336-8H64) [HRP] Summary

Description
This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.
Immunogen
Human recombinant IFN-alpha/beta R1 (extracellular domain)
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
IFNAR1
Purity
Protein G purified
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Applications/Dilutions

Dilutions
  • CyTOF-ready
  • Flow Cytometry
  • Western Blot
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
PBS
Preservative
No Preservative
Purity
Protein G purified

Alternate Names for IFN-alpha/beta R1 Antibody (MM0336-8H64) [HRP]

  • alpha-type antiviral protein
  • AVP
  • beta-type antiviral protein
  • CRF2-1
  • Cytokine receptor class-II member 1
  • Cytokine receptor family 2 member 1
  • human interferon-alpha receptor (HuIFN-alpha-Rec)10IFRC
  • IFN-alpha/beta R1
  • IFN-alpha/beta receptor 1
  • IFN-alpha-REC
  • IFNAR
  • IFNAR1
  • IFN-aR1
  • IFNBR
  • IFNbR1
  • IFN-bR1
  • IFN-R-1
  • interferon (alpha, beta and omega) receptor 1
  • interferon alpha/beta receptor 1
  • interferon-alpha/beta receptor alpha chain
  • interferon-beta receptor 1
  • Type I interferon receptor 1

Background

Interferon alpha receptor 1 (IFN-alpha R1) is a class II cytokine receptor which belongs to type I human interferons (IFNs) family. IFNs plays a role in antiviral, antiproliferative, immunomodulatory, antitumor, and antiparasitic activities by inducing transcription of IFN-stimuated genes (ISGs) through activation of the Jak-STAT pathway. Specifically, IFN- R1 is a 135-kda signal transducing subunit of the IFN alpha/beta receptor complex (IFN-alpha R) (1). IFN-alpha R1 is phospholyated through PTK- and PKC-mediated phosphorylation, which initiates docking of STAT proteins to IFNs. This leads to activation of STAT proteins by PTK-mediated phosphorylation. The mechanism behind the amplification of IFN-alpha R complex mediated transmembrane signaling has been linked to tyrosine phosphorylation on IFN-alpha R1 (2).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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IFN-alpha/beta R1
Antibody (MM0336-8H64 ...
NBP2-11731H
IFN-alpha/beta R1 Antibody (MM0336-8H64) [HRP]
Species: Hu
Applications: WB, Flow, CyTOF-ready

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol IFNAR1