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IFN-alpha/beta R1 Antibody (85228) [PE/Cy7]

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications Flow
Clone
85228
Clonality
Monoclonal
Host
Mouse
Conjugate
PE/Cy7

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
FAB245U-100UG
Alexa Fluor 405
FAB245V-100UG
Alexa Fluor 488
FAB245G-100UG
Alexa Fluor 532
FAB245X
Alexa Fluor 594
FAB245T-100UG
Alexa Fluor 647
FAB245R-100UG
Alexa Fluor 700
FAB245N
Alexa Fluor 750
FAB245S-100UG
Allophycocyanin
FAB245A
Allophycocyanin/Cy7
FAB245APCCY7
Biotin
FAB245B
CoraFluor 1
FAB245CL1
DyLight 350
FAB245D
DyLight 405
FAB245E
DyLight 488
FAB245K
DyLight 550
FAB245L
DyLight 594
FAB245M
DyLight 650
FAB245W
DyLight 680
FAB245Y
DyLight 755
FAB245Z
Fluorescein
FAB245F
HRP
FAB245H
Janelia Fluor 525
FAB245JF525
Janelia Fluor 549
FAB245I
Janelia Fluor 585
FAB245JF585
Janelia Fluor 635
FAB245JF635
Janelia Fluor 646
FAB245J
Janelia Fluor 669
FAB245JF669
PE/Atto594
FAB245PEATT594
PE/Cy5.5
FAB245PECY55
PerCP (Peridinin-chlorophyll Protein Complex)
FAB245C
Phycoerythrin
FAB245P
Unconjugated
MAB245-100
mFluor Violet 450 SE
FAB245MFV450
mFluor Violet 500 SE
FAB245MFV500
mFluor Violet 610 SE
FAB245MFV610
View Available Formulations
Catalog# & Formulation Size Price
Standard Formulation
MAB245-100
Carrier Free
FAB245P
Carrier Free
FAB245A
Carrier Free
FAB245N
Carrier Free
FAB245F
Carrier Free
FAB245C
Carrier Free
MAB245-SP
Carrier Free
MAB245-500
Carrier Free
MAB245-100
Carrier Free
FAB245U-100UG
Carrier Free
FAB245T-100UG
Carrier Free
FAB245S-100UG
Carrier Free
FAB245R-100UG
Carrier Free
FAB245G-100UG
Carrier Free
FAB245V-100UG
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IFN-alpha/beta R1 Antibody (85228) [PE/Cy7] Summary

Immunogen
S. frugiperda insect ovarian cell line Sf 21-derived recombinant human IFN-alpha / beta  R1
Lys28-Lys436
Accession # AAA52730
Specificity
Detects human IFN-alpha / beta R1 in direct ELISAs and Western blots. In direct ELISAs, does not cross-react with recombinant human (rh) IFN‑ gamma  R1, rhIFN-gamma R2, recombinant mouse IFN-alpha / beta  R2, rhIL-10 R beta , rhIL-10 R alpha , or rhIL-20 R beta .
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
IFNAR1
Purity
Protein A or G purified from hybridoma culture supernatant
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.
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Applications/Dilutions

Dilutions
  • Flow Cytometry
Application Notes
Optimal dilution of this antibody should be experimentally determined. For optimal results using our Tandem dyes, please avoid prolonged exposure to light or extreme temperature fluctuations. These can lead to irreversible degradation or decoupling. When staining intracellular targets, specific attention to the fixation and permeabilization steps in your flow protocol may be required. Please contact our technical support team at technical@novusbio.com if you have any questions.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark. Do not freeze.
Buffer
PBS
Preservative
0.05% Sodium Azide
Purity
Protein A or G purified from hybridoma culture supernatant

Alternate Names for IFN-alpha/beta R1 Antibody (85228) [PE/Cy7]

  • alpha-type antiviral protein
  • AVP
  • beta-type antiviral protein
  • CRF2-1
  • Cytokine receptor class-II member 1
  • Cytokine receptor family 2 member 1
  • human interferon-alpha receptor (HuIFN-alpha-Rec)10IFRC
  • IFN-alpha/beta R1
  • IFN-alpha/beta receptor 1
  • IFN-alpha-REC
  • IFNAR
  • IFNAR1
  • IFN-aR1
  • IFNBR
  • IFNbR1
  • IFN-bR1
  • IFN-R-1
  • interferon (alpha, beta and omega) receptor 1
  • interferon alpha/beta receptor 1
  • interferon-alpha/beta receptor alpha chain
  • interferon-beta receptor 1
  • Type I interferon receptor 1

Background

Interferon alpha receptor 1 (IFN-alpha R1) is a class II cytokine receptor which belongs to type I human interferons (IFNs) family. IFNs plays a role in antiviral, antiproliferative, immunomodulatory, antitumor, and antiparasitic activities by inducing transcription of IFN-stimuated genes (ISGs) through activation of the Jak-STAT pathway. Specifically, IFN- R1 is a 135-kda signal transducing subunit of the IFN alpha/beta receptor complex (IFN-alpha R) (1). IFN-alpha R1 is phospholyated through PTK- and PKC-mediated phosphorylation, which initiates docking of STAT proteins to IFNs. This leads to activation of STAT proteins by PTK-mediated phosphorylation. The mechanism behind the amplification of IFN-alpha R complex mediated transmembrane signaling has been linked to tyrosine phosphorylation on IFN-alpha R1 (2).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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FAB245PECY7
IFN-alpha/beta R1 Antibody (85228) [PE/Cy7]
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Bioinformatics

Gene Symbol IFNAR1