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IFN-alpha/beta R1 Antibody (2951C) [Janelia Fluor® 549]

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, Flow
Clone
2951C
Clonality
Monoclonal
Host
Rabbit
Conjugate
Janelia Fluor 549

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
FAB2452U-100UG
Alexa Fluor 405
FAB2452V-100UG
Alexa Fluor 488
FAB2452G-100UG
Alexa Fluor 532
FAB2452X
Alexa Fluor 594
FAB2452T-100UG
Alexa Fluor 647
FAB2452R-100UG
Alexa Fluor 700
FAB2452N-100UG
Alexa Fluor 750
FAB2452S-100UG
Allophycocyanin
FAB2452A
Allophycocyanin/Cy7
FAB2452APCCY7
Biotin
FAB2452B
CoraFluor 1
FAB2452CL1
DyLight 350
FAB2452D
DyLight 405
FAB2452E
DyLight 488
FAB2452K
DyLight 550
FAB2452L
DyLight 594
FAB2452M
DyLight 650
FAB2452W
DyLight 680
FAB2452Y
DyLight 755
FAB2452Z
FITC
FAB2452F
HRP
FAB2452H
Janelia Fluor 525
FAB2452JF525
Janelia Fluor 585
FAB2452JF585
Janelia Fluor 635
FAB2452JF635
Janelia Fluor 646
FAB2452J
Janelia Fluor 669
FAB2452JF669
PE
FAB2452P
PE/Atto594
FAB2452PEATT594
PE/Cy5.5
FAB2452PECY55
PE/Cy7
FAB2452PECY7
PerCP
FAB2452C
Unconjugated
MAB2452-100
mFluor Violet 450 SE
FAB2452MFV450
mFluor Violet 500 SE
FAB2452MFV500
mFluor Violet 610 SE
FAB2452MFV610
View Available Formulations
Catalog# & Formulation Size Price
Standard Formulation
MAB2452-100
Carrier Free
MAB2452-100
Carrier Free
MAB2452-SP
Carrier Free
FAB2452V-100UG
Carrier Free
FAB2452T-100UG
Carrier Free
FAB2452N-100UG
Carrier Free
FAB2452R-100UG
Carrier Free
FAB2452G-100UG
Carrier Free
FAB2452U-100UG
Carrier Free
FAB2452S-100UG
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IFN-alpha/beta R1 Antibody (2951C) [Janelia Fluor® 549] Summary

Additional Information
Recombinant Monoclonal Antibody.
Immunogen
Mouse myeloma cell line, NS0-derived human IFN-alpha/beta R1
Gly26-Lys436
Accession # P17181
Specificity
Detects human IFN‑ alpha / beta  R1 in direct ELISA.
Isotype
IgG
Clonality
Monoclonal
Host
Rabbit
Purity
Protein A or G purified from hybridoma culture supernatant
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Applications/Dilutions

Dilutions
  • Flow Cytometry
  • Western Blot
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Protein A or G purified from hybridoma culture supernatant

Notes



Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

Alternate Names for IFN-alpha/beta R1 Antibody (2951C) [Janelia Fluor® 549]

  • alpha-type antiviral protein
  • AVP
  • beta-type antiviral protein
  • CRF2-1
  • Cytokine receptor class-II member 1
  • Cytokine receptor family 2 member 1
  • human interferon-alpha receptor (HuIFN-alpha-Rec)10IFRC
  • IFN-alpha/beta R1
  • IFN-alpha/beta receptor 1
  • IFN-alpha-REC
  • IFNAR
  • IFNAR1
  • IFN-aR1
  • IFNBR
  • IFNbR1
  • IFN-bR1
  • IFN-R-1
  • interferon (alpha, beta and omega) receptor 1
  • interferon alpha/beta receptor 1
  • interferon-alpha/beta receptor alpha chain
  • interferon-beta receptor 1
  • Type I interferon receptor 1

Background

Interferon alpha receptor 1 (IFN-alpha R1) is a class II cytokine receptor which belongs to type I human interferons (IFNs) family. IFNs plays a role in antiviral, antiproliferative, immunomodulatory, antitumor, and antiparasitic activities by inducing transcription of IFN-stimuated genes (ISGs) through activation of the Jak-STAT pathway. Specifically, IFN- R1 is a 135-kda signal transducing subunit of the IFN alpha/beta receptor complex (IFN-alpha R) (1). IFN-alpha R1 is phospholyated through PTK- and PKC-mediated phosphorylation, which initiates docking of STAT proteins to IFNs. This leads to activation of STAT proteins by PTK-mediated phosphorylation. The mechanism behind the amplification of IFN-alpha R complex mediated transmembrane signaling has been linked to tyrosine phosphorylation on IFN-alpha R1 (2).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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IFN-alpha/beta R1
Antibody (2951C) [Jan ...
FAB2452I
IFN-alpha/beta R1 Antibody (2951C) [Janelia Fluor® 549]
Species: Hu
Applications: WB, Flow

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