Human ULBP-2 DuoSet ELISA, 15 Plate

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. The name ULBP derives from the original identification of three proteins, ULBP-1, -2, and -3, as ligands for the human cytomegalovirus glycoprotein UL16; they were designated UL16 binding proteins (ULBP). The genes for ULBPs reside in a cluster of ten related genes, six of which encode potentially functional glycoproteins. ULBP-2 has also been described under the names RaeT1H (retinoic acid early transcript), NKG2DL2, and ALCAN-alpha. ULBP-5 is also known as RaeT1G and ULBP-6 is also known as RaeT1L. These proteins are distantly related to MHC class I proteins, but they possess only the alpha 1 and alpha 2 Ig-like domains, and they have no capacity to bind peptide or interact with beta 2-Microglobulin. Some family members, including ULBP-2, are anchored to the membrane via a GPI-linkage, whereas others have transmembrane domains. Engagement of NKG2D results in the activation of cytolytic activity and/or cytokine production by these effector cells. The ULBPs are expressed on some tumor cells and have been implicated in tumor surveillance. Over aa 26-217, ULBP-2 shares 92% and 95% aa sequence identity with the human ULBP-5 and ULBP-6, respectively.

We have publications tested in 1 confirmed species: Human.

Showing Publications 1 - 8 of 8.

Publications using DY1298	Applications	Species
Vulpis, E;Loconte, L;Cassone, C;Antonangeli, F;Caracciolo, G;Masuelli, L;Fazio, F;Petrucci, MT;Fionda, C;Soriani, A;Cerboni, C;Cippitelli, M;Santoni, A;Zingoni, A; Cross-Dressing of Multiple Myeloma Cells Mediated by Extracellular Vesicles Conveying MIC and ULBP Ligands Promotes NK Cell Killing International journal of molecular sciences 2023-05-30 [PMID: 37298418] (Human)		Human
MJ Lee, MW Leong, A Rustagi, A Beck, L Zeng, S Holmes, LS Qi, CA Blish SARS-CoV-2 escapes direct NK cell killing through Nsp1-mediated downregulation of ligands for NKG2D Cell Reports, 2022-12-12;41(13):111892. 2022-12-12 [PMID: 36543165] (Human)		Human
Expression and prognostic significance of unique ULBPs in pancreatic cancer Onco Targets Ther, 2016-08-25;9(0):5271-9. 2016-08-25 [PMID: 27621649] (Human)		Human
Cox S, Laza-Briviesca R, Pearson H, Soria B, Gibson D, Gomez S, Madrigal J, Saudemont A Umbilical cord blood plasma contains soluble NKG2D ligands that mediate loss of natural killer cell function and cytotoxicity. Eur J Immunol, 2015-06-09;45(8):2324-34. 2015-06-09 [PMID: 25991034] (Human)		Human
Giannattasio A, Weil S, Kloess S, Ansari N, Stelzer E, Cerwenka A, Steinle A, Koehl U, Koch J Cytotoxicity and infiltration of human NK cells in in vivo-like tumor spheroids. BMC Cancer, 2015-05-03;15(0):351. 2015-05-03 [PMID: 25933805] (Human)		Human
Gonzalez-Foruria I, Santulli P, Chouzenoux S, Carmona F, Batteux F, Chapron C Soluble ligands for the NKG2D receptor are released during endometriosis and correlate with disease severity. PLoS ONE, 2015-03-16;10(3):e0119961. 2015-03-16 [PMID: 25775242] (Human)		Human
Wang , Ruipeng, Sun , Peter D Natural killer cell-mediated shedding of ULBP2. PLoS ONE, 2014-03-10;9(3):e91133. 2014-03-10 [PMID: 24614922] (Human)		Human
Reiners K, Kessler J, Sauer M, Rothe A, Hansen H, Reusch U, Hucke C, Kohl U, Durkop H, Engert A, von Strandmann E Rescue of impaired NK cell activity in hodgkin lymphoma with bispecific antibodies in vitro and in patients. Mol Ther, 2013-03-05;21(4):895-903. 2013-03-05 [PMID: 23459515] (Human)		Human

Array DY1298

• ULBP-2 Antibodies
• ULBP-2 Lysate
• ULBP-2 Protein
• ULBP-2 ELISA
• ULBP-2 Proteins and Enzymes