Human PlGF DuoSet ELISA, 15 Plate

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

PlGF (placenta growth factor) is a homodimeric growth factor that competes with VEGF for binding to VEGF R1/Flt-1. It therefore increases the availability of VEGF to bind to VEGF R2/KDR/Flk-1 and trigger angiogenesis. It can form heterodimers with some forms of VEGF and decrease the angiogenic effect of VEGF on VEGF R2. Circulating PlGF levels increase during pregnancy, reaching a peak in mid-gestation; this increase is attenuated in preeclampsia. PlGF induces monocyte activation and migration as well as production of inflammatory cytokines and VEGF. These activities facilitate wound, bone fracture, and cardiac repair, but also contribute to inflammation in active sickle cell disease and atherosclerosis. PlGF can also inhibit TIMP3 expression in the spleen, leading to immune triggering of hypertension.

We have publications tested in 1 confirmed species: Human.

Showing Publications 1 - 10 of 17. Show All 17 Publications. Collapse Publications.

Publications using DY264	Applications	Species
Lekva, T;Sundaram, AYF;Roland, MCP;Åsheim, J;Michelsen, AE;Norwitz, ER;Aukrust, P;Gilfillan, GD;Ueland, T; Platelet and mitochondrial RNA is decreased in plasma-derived extracellular vesicles in women with preeclampsia-an exploratory study BMC medicine 2023-11-23 [PMID: 37996819] (Human)		Human
X Xie, D Chen, X Yang, Y Cao, Y Guo, W Cheng Combination of Maternal Serum ESM-1 and PLGF with Uterine Artery Doppler PI for Predicting Preeclampsia Journal of Clinical Medicine, 2023-01-06;12(2):. 2023-01-06 [PMID: 36675388] (Human)		Human
E Kadife, N Hannan, A Harper, N Binder, S Beard, FC Brownfoot Hydroxychloroquine reduces soluble Flt-1 secretion from human cytotrophoblast, but does not mitigate markers of endothelial dysfunction in vitro PLoS ONE, 2022-11-23;17(11):e0271560. 2022-11-23 [PMID: 36417467] (Human)		Human
A Tosi, L Nardinocch, ML Carbone, L Capriotti, E Pagani, S Mastroeni, C Fortes, F Scopelliti, C Cattani, F Passarelli, A Rosato, S D'Atri, CM Failla, A Cavani Reduced Interleukin-17-Expressing Cells in Cutaneous Melanoma Biomedicines, 2021-12-16;9(12):. 2021-12-16 [PMID: 34944746] (Human)		Human
SC Lean, RL Jones, SA Roberts, AEP Heazell A prospective cohort study providing insights for markers of adverse pregnancy outcome in older mothers BMC pregnancy and childbirth, 2021-10-20;21(1):706. 2021-10-20 [PMID: 34670515] (Human)		Human
S Sissaoui, S Egginton, L Ting, A Ahmed, PW Hewett Hyperglycaemia up-regulates placental growth factor (PlGF) expression and secretion in endothelial cells via suppression of PI3 kinase-Akt signalling and activation of FOXO1 Scientific Reports, 2021-08-11;11(1):16344. 2021-08-11 [PMID: 34381074] (Human)		Human
NA Rashdan, B Zhai, PC Lovern Fluid shear stress regulates placental growth factor expression via heme oxygenase 1 and iron Scientific Reports, 2021-07-21;11(1):14912. 2021-07-21 [PMID: 34290391] (Human)		Human
A Djeha, S Girard, H Trottier, F Kakkar, H Soudeyns, M Boucher, N Lapointe, I Boucoiran No association between early antiretroviral therapy during pregnancy and plasma levels of angiogenic factors: a cohort study BMC Pregnancy Childbirth, 2019-12-09;19(1):482. 2019-12-09 [PMID: 31815612] (Human)		Human
FC Brownfoot, NJ Hannan, P Cannon, V Nguyen, R Hastie, LJ Parry, S Senadheera, L Tuohey, S Tong, TJ Kaitu'u-Li Sulfasalazine reduces placental secretion of antiangiogenic factors, up-regulates the secretion of placental growth factor and rescues endothelial dysfunction EBioMedicine, 2019-02-26;0(0):. 2019-02-26 [PMID: 30824385] (Human)		Human
SC Lean, AEP Heazell, MR Dilworth, TA Mills, RL Jones Placental Dysfunction Underlies Increased Risk of Fetal Growth Restriction and Stillbirth in Advanced Maternal Age Women Sci Rep, 2017-08-29;7(1):9677. 2017-08-29 [PMID: 28852057] (Human)		Human
Angiogenic proteins, placental weight and perinatal outcomes among pregnant women in Tanzania PLoS ONE, 2016-12-09;11(12):e0167716. 2016-12-09 [PMID: 27936130] (Human)		Human
McDonald C, Darling A, Conroy A, Tran V, Cabrera A, Liles W, Wang M, Aboud S, Urassa W, Fawzi W, Kain K Inflammatory and Angiogenic Factors at Mid-Pregnancy Are Associated with Spontaneous Preterm Birth in a Cohort of Tanzanian Women. PLoS ONE, 2015-08-06;10(8):e0134619. 2015-08-06 [PMID: 26247200] (Human)		Human
Kaitu'u-Lino TJ, Whitehead CL, Ngian GL, Permezel M, Tong S Serum concentrations of soluble Flt-1 are decreased among women with a viable fetus and no symptoms of miscarriage destined for pregnancy loss. PLoS ONE, 2012-02-28;7(2):e32509. 2012-02-28 [PMID: 22389705] (Human)		Human
Jeevaratnam K, Nadarajah VD, Judson JP Periodic assessment of plasma sFlt-1 and PlGF concentrations and its association with placental morphometry in gestational hypertension (GH) - a prospective follow-up study. BMC Pregnancy Childbirth, 2010-09-28;10(0):58. 2010-09-28 [PMID: 20920154] (Human)		Human
Lash GE, Naruse K, Innes BA, Robson SC, Searle RF, Bulmer JN Secretion of angiogenic growth factors by villous cytotrophoblast and extravillous trophoblast in early human pregnancy. Placenta, 2010-03-24;31(6):545-8. 2010-03-24 [PMID: 20338637] (Human)		Human
Tsujioka H, Imanishi T, Ikejima H, Kuroi A, Takarada S, Tanimoto T, Kitabata H, Okochi K, Arita Y, Ishibashi K, Komukai K, Kataiwa H, Nakamura N, Hirata K, Tanaka A, Akasaka T Impact of heterogeneity of human peripheral blood monocyte subsets on myocardial salvage in patients with primary acute myocardial infarction. J. Am. Coll. Cardiol., 2009-07-07;54(2):130-8. 2009-07-07 [PMID: 19573729] (Human)		Human
Li H, Gu B, Zhang Y, Lewis DF, Wang Y Hypoxia-induced increase in soluble Flt-1 production correlates with enhanced oxidative stress in trophoblast cells from the human placenta. Placenta, 2005-02-01;26(2):210-7. 2005-02-01 [PMID: 15708122] (Human)		Human
Show All 17 Publications. Collapse Publications.

Array DY264

• PLGF Antibodies
• PLGF Proteins
• PLGF Proteins and Enzymes
• PLGF ELISAs