Human OX40/TNFRSF4 DuoSet ELISA, 5 Plate

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

OX40 (CD134; TNFRSF4) is a T cell costimulatory molecule of the TNF receptor superfamily that coordinates with other costimulators (CD28, CD40, CD30, CD27 and 4-1BB) to manage the activation of the immune response. OX40 is upregulated on antigen activated CD4+ and CD8+ T cells with costimulation by CD40-CD40 Ligand and CD28-B7. OX40 interactions with OX40 Ligand on antigen presenting cells enhances T cell survival, proliferation, and cytokine production. It also inhibits the conversion of effector T cells into regulatory T cells (Tregs) and can promote the maintenance of and recall response in memory T cells. OX40 is constitutively expressed on Tregs where it promotes Treg proliferation and immunosuppressive activity. OX40-OX40 Ligand signaling is involved in allergic airway inflammation, graft-versus-host disease, and autoimmune disease.

We have publications tested in 1 confirmed species: Human.

Showing Publication 1 - 1 of 1.

Publication using DY3388-05	Applications	Species
D Cui, Y Lv, X Yuan, G Ruan, Y Zhang, C Yan, D Xu, M Lv, Y Mao, J Cao, J Jin, J Xie Increased Expressions of OX40 and OX40 Ligand in Patients with Primary Immune Thrombocytopenia J Immunol Res, 2019-03-03;2019(0):6804806. 2019-03-03 [PMID: 30944836] (Human)		Human

Array DY3388-05

• OX40/TNFRSF4 Antibodies
• OX40/TNFRSF4 ELISA Kit
• OX40/TNFRSF4 Lysate
• OX40/TNFRSF4 ELISA
• OX40/TNFRSF4 Proteins and Enzymes