Human Lymphotoxin-alpha/TNF-beta DuoSet ELISA, 15 Plate

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Lymphotoxin alpha and Lymphotoxin beta are pro-inflammatory TNF superfamily ligands that play important roles in immune system development. LT-alpha can be secreted as a homotrimer that binds and activates TNF RI, TNF RII, HVEM, and TROY. It is required for development of the spleen, lymph nodes, and Peyer’s patches. It also regulates T cell homing to the gut and IgA induction. LT-alpha can additionally form membrane-associated heterotrimers with two copies of LT-beta/TNF-beta on the surface of B, T, LTi, and ILC3 cells. This heterotrimer binds and activates the Lymphotoxin beta R on macrophages, dendritic cells, hepatocytes, intestinal epithelial cells (IEC), follicular dendritic cells (FDC), and high endothelial venules (HEV). The heterotrimer promotes the development of FDC networks and HEV in lymphoid tissue, the class switching of immature B cells for IgA production, and the production of homeostatic IL-22 by IEC.

We have publications tested in 3 confirmed species: Human, Mouse, Rat.

Showing Publications 1 - 5 of 5.

Publications using DY211	Applications	Species
E Simader, L Beer, M Laggner, V Vorstandle, A Gugerell, M Erb, P Kalinina, D Copic, D Moser, A Spittler, E Tschachler, H Jan Ankers, M Mildner Tissue-regenerative potential of the secretome of gamma-irradiated peripheral blood mononuclear cells is mediated via TNFRSF1B-induced necroptosis Cell Death Dis, 2019-09-30;10(10):729. 2019-09-30 [PMID: 31570701] (Human)		Human
C Zhang, J Zhan, M Zhao, H Dai, Y Deng, W Zhou, L Zhao Protective mechanism of Taxifolin for chlorpyrifos neurotoxicity in BV2 cells Neurotoxicology, 2019-05-29;74(0):74-80. 2019-05-29 [PMID: 31152760] (Mouse)		Mouse
CC Tsai, YJ Lin, HR Yu, JM Sheen, IC Lin, YJ Lai, YL Tain, LT Huang, MM Tiao Regulation of Leptin Methylation Not via Apoptosis by Melatonin in the Rescue of Chronic Programming Liver Steatosis Int J Mol Sci, 2018-11-12;19(11):. 2018-11-12 [PMID: 30424542] (Rat)		Rat
Sarhan D, Palma M, Mao Y, Adamson L, Kiessling R, Mellstedt H, Osterborg A, Lundqvist A Dendritic cell regulation of NK-cell responses involves lymphotoxin-alpha, IL-12, and TGF-beta. Eur J Immunol, 2015-04-17;45(6):1783-93. 2015-04-17 [PMID: 25773885] (Human)		Human
Correale J, Farez M, Razzitte G Helminth infections associated with multiple sclerosis induce regulatory B cells. Ann. Neurol., 2008-08-01;64(2):187-99. 2008-08-01 [PMID: 18655096] (Human)		Human

Array DY211

• Lymphotoxin-alpha/TNF-beta Antibodies
• Lymphotoxin-alpha/TNF-beta Antibody Pair
• Lymphotoxin-alpha/TNF-beta ELISA Kits
• Lymphotoxin-alpha/TNF-beta Proteins
• Lymphotoxin-alpha/TNF-beta Proteins and Enzymes
• Lymphotoxin-alpha/TNF-beta ELISA