Novus Biologicals products are now on bio-techne.com

Human IL-6R alpha DuoSet ELISA, 15 Plate

Images

 

Product Details

Summary
Reactivity HuSpecies Glossary
Applications ELISA
Conjugate
Biotin

Order Details

Novus Biologicals is part of Bio-Techne

Shop this product on bio-techne.com

Human IL-6R alpha DuoSet ELISA, 15 Plate Summary

Source
N/A
Assay Type
Solid Phase Sandwich ELISA
Inter-Assay
See PDF Datasheet for details
Intra-Assay
See PDF Datasheet for details
Spike Recovery
See PDF Datasheet for details
Sample Volume
See PDF Datasheet for details
Gene
IL6R

Applications/Dilutions

Dilutions
  • ELISA
Application Notes
No significant interference observed with available related molecules.
Publications
Read Publications using DY227.

Packaging, Storage & Formulations

Storage
Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human IL-6R alpha DuoSet ELISA, 15 Plate

  • CD126
  • gp80
  • IL-6 R alpha
  • IL6Q
  • IL6R alpha
  • IL-6R alpha
  • IL6R
  • IL-6R-1
  • IL6RA
  • IL-6Ra
  • IL6RQ
  • interleukin 6 receptor

Background

IL-6 R alpha is a transmembrane subunit of the receptor for Interleukin-6. It associates with gp130 which is a shared component of the receptors for CLC, CNTF, CT-1, IL-11, IL-27, LIF, and OSM. Soluble forms of IL-6 R alpha are generated by both alternative splicing and proteolytic cleavage. In a mechanism known as trans-signaling, complexes of soluble IL-6 and IL-6 R alpha elicit responses from gp130-expressing cells that lack cell surface IL-6 R alpha. IL-6 plays important roles in the acute phase reaction, inflammation, hematopoiesis, bone metabolism, and cancer progression. IL-6, along with TNF-alpha and IL-1, drives the acute inflammatory response and the transition from acute inflammation to either acquired immunity or chronic inflammatory disease. When dysregulated, it contributes to chronic inflammation in obesity, insulin resistance, inflammatory bowel disease, arthritis, sepsis, and atherosclerosis.

Customers Who Viewed This Item Also Viewed...

M6000B
Species: Mu
Applications: ELISA
DGP00
Species: Hu
Applications: ELISA
NBP1-83349
Species: Hu
Applications: ICC/IF, IHC, IHC-P, KD, WB
7268-CT
Species: Hu
Applications: BA
NB100-524
Species: Hu, Mu
Applications: Flow-IC, Flow, ICC/IF, IHC, IHC-Fr, IHC-P, IP, WB
NBP2-79843
Species: Hu
Applications: CyTOF-ready, ELISA, Flow, ICC/IF, IHC, IHC-P, PA, WB
MAB1799
Species: Hu, Mu, Rt
Applications: ICC, IP, ICFlow, KO, WB
DY1707
Species: Hu
Applications: ELISA
AF2747
Species: Mu
Applications: ELISA(Cap), ELISA(Det), ELISA(Sta), IHC, IP, WB
DY417
Species: Mu
Applications: ELISA
8475-OM/CF
Species: Hu
Applications: BA
NB400-141
Species: Ha, Hu, Mu
Applications: ICC/IF, IP, WB
202-IL
Species: Hu
Applications: BA
DR2A00
Species: Hu
Applications: ELISA
AF5739
Species: Hu, Mu, Rt
Applications: WB
7734-LF
Species: Hu
Applications: BA
NBP2-22203
Species: Hu, Pm, Mu, Rt
Applications: ELISA, Flow, ICC/IF, IHC, IHC-P, WB

Publications for IL-6R alpha (DY227)(18)

We have publications tested in 3 confirmed species: Human, Mouse, Transgenic Mouse.


Filter By Application
All Applications
Filter By Species
Human
(17)
Mouse
(1)
Transgenic Mouse
(1)
All Species
Showing Publications 1 - 10 of 18. Show All 18 Publications.
Publications using DY227 Applications Species
W Zhang, BY Chua, KJ Selva, L Kedzierski, TM Ashhurst, ER Haycroft, SK Shoffner-B, L Hensen, DF Boyd, F James, E Mouhtouris, JC Kwong, KYL Chua, G Drewett, A Copaescu, JE Dobson, LC Rowntree, JR Habel, LF Allen, HF Koay, JA Neil, MJ Gartner, CY Lee, P Andersson, SF Khan, L Blakeway, J Wisniewski, JH McMahon, EE Vine, AL Cunningham, J Audsley, I Thevarajan, T Seemann, NL Sherry, F Amanat, F Krammer, SL Londrigan, LM Wakim, NJC King, DI Godfrey, LK Mackay, PG Thomas, S Nicholson, KB Arnold, AW Chung, NE Holmes, OC Smibert, JA Trubiano, CL Gordon, THO Nguyen, K Kedzierska SARS-CoV-2 infection results in immune responses in the respiratory tract and peripheral blood that suggest mechanisms of disease severity Nature Communications, 2022-05-19;13(1):2774. 2022-05-19 [PMID: 35589689] (Human) Human
M Machci?ska, M Kierasi?sk, M Michniowsk, M Maruszewsk, L Szewczak, R Rola, A Karli?ska, M Stear, K Donskow-?y Reduced Expression of PD-1 in Circulating CD4+ and CD8+ Tregs Is an Early Feature of RRMS International Journal of Molecular Sciences, 2022-03-16;23(6):. 2022-03-16 [PMID: 35328606] (Human) Human
W Zhang, B Chua, K Selva, L Kedzierski, T Ashhurst, E Haycroft, S Shoffner, L Hensen, D Boyd, F James, E Mouhtouris, J Kwong, K Chua, G Drewett, A Copaescu, J Dobson, L Rowntree, J Habel, L Allen, HF Koay, J Neil, M Gartner, C Lee, P Andersson, T Seemann, N Sherry, F Amanat, F Krammer, S Londrigan, L Wakim, N King, D Godfrey, L Mackay, P Thomas, S Nicholson, K Arnold, A Chung, N Holmes, O Smibert, J Trubiano, C Gordon, T Nguyen, K Kedzierska Immune responses in COVID-19 respiratory tract and blood reveal mechanisms of disease severity Research square, 2021-08-26;0(0):. 2021-08-26 [PMID: 34462740] (Human) Human
E Georgieva, SL Leber, C Wex, C Garbers Perturbation of the Actin Cytoskeleton in Human Hepatoma Cells Influences Interleukin-6 (IL-6) Signaling, but Not Soluble IL-6 Receptor Generation or NF-kappaB Activation International Journal of Molecular Sciences, 2021-07-02;22(13):. 2021-07-02 [PMID: 34281231] (Human) Human
CM Flynn, B Kespohl, T Daunke, Y Garbers, S Düsterhöft, S Rose-John, J Haybaeck, J Lokau, S Aparicio-S, C Garbers Interleukin-6 controls recycling and degradation, but not internalization of its receptors The Journal of Biological Chemistry, 2021-02-19;0(0):100434. 2021-02-19 [PMID: 33610555] (Human) Human
CM Flynn, Y Garbers, S Düsterhöft, R Wichert, J Lokau, CHK Lehmann, D Dudziak, B Schröder, C Becker-Pau, S Rose-John, S Aparicio-S, C Garbers Cathepsin S provokes interleukin-6 (IL-6) trans-signaling through cleavage of the IL-6 receptor in vitro Scientific Reports, 2020-12-10;10(1):21612. 2020-12-10 [PMID: 33303781] (Human) Human
M Werner-Kle, A Grujovic, C Irlbeck, M Obradovi?, M Hoffmann, H Koerkel-Qu, X Lu, S Treitschke, C Köstler, C Botteron, K Weidele, C Werno, B Polzer, S Kirsch, M Gužvi?, J Warfsmann, K Honarnejad, Z Czyz, G Feliciello, I Blochberge, S Grunewald, E Schneider, G Haunschild, N Patwary, S Guetter, S Huber, B Rack, N Harbeck, S Buchholz, P Rümmele, N Heine, S Rose-John, CA Klein Interleukin-6 trans-signaling is a candidate mechanism to drive progression of human DCCs during clinical latency Nat Commun, 2020-10-05;11(1):4977. 2020-10-05 [PMID: 33020483] (Human) Human
S Gupta, GY Junquera, L Nicassio, B Becknell, CB Ching Trans IL-6 signaling does not appear to play a role in renal scarring after urinary tract infection J Pediatr Urol, 2020-05-29;0(0):. 2020-05-29 [PMID: 32563691] (Human) Human
CM Flynn, Y Garbers, J Lokau, D Wesch, DM Schulte, M Laudes, W Lieb, S Aparicio-S, C Garbers Activation of Toll-like Receptor 2 (TLR2) induces Interleukin-6 trans-signaling Sci Rep, 2019-05-13;9(1):7306. 2019-05-13 [PMID: 31086276] (Human) Human
N Prenissl, J Lokau, S Rose-John, J Haybaeck, C Garbers Therapeutic blockade of the interleukin-6 receptor (IL-6R) allows sIL-6R generation by proteolytic cleavage Cytokine, 2018-12-14;114(0):1-5. 2018-12-14 [PMID: 30557809] (Human, Transgenic Mouse) Human, Transgenic Mouse
Show All 18 Publications.

Reviews for IL-6R alpha (DY227) (0)

There are no reviews for IL-6R alpha (DY227). By submitting a review you will receive an Amazon e-Gift Card or Novus Product Discount.
  • Review with no image -- $10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen
  • Review with an image -- $25/€18/£15/$25 CAD/¥150 Yuan/¥2500 Yen

Product General Protocols

Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

FAQs for IL-6R alpha (DY227) (0)

There are no specific FAQs related to this product. Read our general customer & technical service FAQs.

Additional IL-6R alpha Products

Blogs on IL-6R alpha

There are no specific blogs for IL-6R alpha, but you can read our latest blog posts.
Read our latest blog and use the new citation tool on bio-techne.com

Customers Who Bought This Also Bought

Contact Information

Product PDFs

Review this Product

Be the first to review our Human IL-6R alpha DuoSet ELISA, 15 Plate and receive a gift card or discount.

Bioinformatics

Gene Symbol IL6R